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Keywords:

  • cord serum;
  • IgG subclasses;
  • immunoassay;
  • latex agglutination;
  • smoking

IgG subclass levels in cord serum of unselected European newborns were studied in relation to parental smoking. Cord IgG3 was significantly (P < 0.01) higher in newborns of smoking mothers (n= 18; geom.mean = 87.0%) compared to those of non-smoking mothers (n= 66; geom.mean = 61.0%). Maternal smoking did not influence (P > 0.10) cord IgG2 or cord IgG4. Paternal smoking did not affect any of the three immunoglobulins in cord serum (P > 0.10). These data suggest that tobacco smoking affects IgG3 synthesis in some direct or indirect way.