This study was made possible due to grants from Pharmacia Diagnostics, Uppsala and Draco, Lund (subsidiary to AB Astra, SÖdertälje). Skilful technical assistance was given by Ing-Marie Sandberg, Karin Andrae, and Kerstin Hagersten. Excellent work with data computerizing done by Janis Ezitis, M.D. and statistical advice by Erik Leander, senior lecturer, is gratefully acknowledged.
Natural history of bronchial asthma in childhood A prospective study from birth up to 12–14 years of age
Article first published online: 28 APR 2007
Volume 47, Issue 2, pages 150–157, April 1992
How to Cite
Croner, S. and Kjellman, N.-I. M. (1992), Natural history of bronchial asthma in childhood A prospective study from birth up to 12–14 years of age. Allergy, 47: 150–157. doi: 10.1111/j.1398-9995.1992.tb00956.x
- Issue published online: 28 APR 2007
- Article first published online: 28 APR 2007
- Accepted for publication 19 September 1991
- cord blood IgE;
- histamine challenge;
- asthma score
Croner S, Kjellman N-IM. Natural history of bronchial asthma in childhood. A prospective study from birth up to 12-14 years of age.
In a cohort of 1654 consecutively born children followed from birth, the cumulated incidence of asthma up to 11 years was 5.3% and the prevalence 3% between 10 and 11 years of age. The asthma debut was prior to 1.5 years in 1/3 and before 3 years in 1/2 of the children. Among 59 children examined at 11.5–14.5 years of age, 16 (27%) had no prevalent asthma. On the other hand, inadequate medication was found in 13, undiagnosed chest deformity in four, and wheezing in seven children. All 54 tested children including those with no prevalent asthma had a PC20 histaminc < 8 mg/ml. Tread mill test gave a significant reaction in 15 children. Animal danders and pollens were the most common allergens giving reactions at skin prick test. Compared to one earlier Swedish study an increase in mite sensitivity was found. Cord-blood IgE concentration and a positive immediate family history of atopic disease had no predictive value for the severity of asthma at this follow-up. A new total asthma score including number of days with functional impact of asthma during the last year and present medication was used for group comparisons. Children with a high score at 11.5–14.5 years had more exercise-induced asthma, more concomitant allergic diseases, earlier asthma start, more chest deformity, hyperreactivity both on tread mill and histamine challenge tests, elevated IgE, positive Phadiatop and more reactions at skin prick test, especially to animals and mites. Bronchial asthma was found more often in children born during August through October, possibly due to unsuitable indoor climate and more virus infections during their first 6 months of life. The severity of the asthma was, however, not influenced by the month of birth. No significant differences were found between boys and girls regarding the age at début, asthma severity at follow-up, or bronchial histamine threshold levels.