Sinus CT scans and mediator release in nasal secretions after nasal challenge with cypress pollens
Article first published online: 1 JUL 2004
Volume 59, Issue 8, pages 863–868, August 2004
How to Cite
Piette, V., Bousquet, C., Kvedariene, V., Dhivert-Donnadieu, H., Crampette, L., Senac, J.-P., Bousquet, J. and Demoly, P. (2004), Sinus CT scans and mediator release in nasal secretions after nasal challenge with cypress pollens. Allergy, 59: 863–868. doi: 10.1111/j.1398-9995.2004.00509.x
- Issue published online: 1 JUL 2004
- Article first published online: 1 JUL 2004
- Accepted for publication 7 January 2004
- cypress pollen;
- intermittent allergic rhinitis;
- leucotriene C4;
- nasal provocation test;
- sinus tomodensitometry;
Background: Involvement of paranasal sinuses has been suggested in allergic rhinitis but not clearly demonstrated.
Aims: To investigate the relationship between intermittent allergic rhinitis and computerized tomography (CT).
Methods: Twenty patients with intermittent rhinitis and sensitized to cypress pollens underwent unilateral nasal provocation tests (NPTs) using increasing concentrations of cypress pollens out of the pollen season. Sinus CT-scans were carried out just before a NPT and 24 h later. Nasal lavage was carried out just before a NPT, 30 min after a positive challenge and again 24 h later. Leucotriene C4/D4, intracellular adhesion molecule-1 and eosinophil cationic protein were measured in nasal secretions.
Results: Thirteen patients (65%) showed an alteration in their CT-scans after allergen challenge. Ten of them showed sinus changes controlateral to their allergenic provocation. Radiological changes mainly affected the osteomeatal complex and the ethmoid sinuses. Pre-existing abnormalities (13 of 20 cases) mainly concerned the maxillary sinuses. There was no correlation between CT-scan abnormalities and levels of mediators released in nasal secretions.
Conclusions: We have shown that nasal allergen challenge can produce radiological changes in the paranasal sinuses. This mainly concerned the ethmoid sinuses.