Allergy to jackfruit: a novel example of Bet v 1-related food allergy
Version of Record online: 2 SEP 2004
Volume 59, Issue 11, pages 1187–1192, November 2004
How to Cite
Bolhaar, S. T. H. P., van Ree, R., Bruijnzeel-Koomen, C. A. F. M., Knulst, A. C. and Zuidmeer, L. (2004), Allergy to jackfruit: a novel example of Bet v 1-related food allergy. Allergy, 59: 1187–1192. doi: 10.1111/j.1398-9995.2004.00544.x
- Issue online: 2 SEP 2004
- Version of Record online: 2 SEP 2004
- Accepted for publication 9 February 2004
- Bet v 1;
- double-blind placebo-controlled food challenge;
Background: Jackfruit allergy has been reported just once. It is unknown whether this food allergy is caused by direct sensitization or cross-sensitization to pollen allergens.
Objective: Establish whether jackfruit allergy is linked to birchpollen allergy.
Methods: Two jackfruit allergic patients and five patients with birchpollen-related apple allergy were recruited. Sensitization to pollen and plant foods was assessed by skin prick test (SPT), radio-allergosorbent test (RAST) and immunoblot. RAST analysis was performed for Bet v 1 and Mal d 1. Cross-reactivity was evaluated by RAST and immunoblot-inhibition. Biological activity of immunoglobulin E (IgE) was measured by basophil histamine release. Allergy to jackfruit was evaluated by double-blind placebo-controlled food challenge (DBPCFC) or open challenge (OC).
Results: In both patients DBPCFC confirmed the reported jackfruit allergy. SPT was 41 and 27 mm2 and specific IgE to jackfruit was 5.9 and 0.8 IU/ml, respectively. Immunoblot analysis revealed IgE reactivity at Mr of approximately 17 kDa. The Bet v 1-related nature of this allergen in jackfruit was demonstrated by RAST and immunoblot inhibition. To assess whether jackfruit allergy might be common in patients with combined birchpollen-fruit allergy, five such patients underwent an OC with jackfruit. All five had OA-like symptoms.
Conclusions: Jackfruit allergy can be added to the list of birchpollen-related food allergies. Increased consumption of this fruit will result in a rise in allergic reactions.