• 1
    Douwes J, Pearce N, Heederik D. Does environmental endotoxin exposure prevent asthma? Thorax 2002;57: 8690.
  • 2
    Park JH, Spiegelman DL, Burge HA, Gold DR, Chew GL, Milton DK. Longitudinal study of dust and airborne endotoxin in the home. Environ Health Perspect 2000;108: 10231028.
  • 3
    von Mutius E, Braun-Fahrlander C, Schierl R, Riedler J, Ehlermann S, Maisch S et al. Exposure to endotoxin or other bacterial components might protect against the development of atopy. Clin Exp Allergy 2000;30: 12301234.
  • 4
    Douwes J, Zuidhof A, Doekes G, van Der ZEE, Wouters I, Marike BH et al. (1 [RIGHTWARDS ARROW] 3)-beta-D-Glucan and endotoxin in house dust and peak flow variability in children. Am J Respir Crit Care Med 2000;162: 13481354.
  • 5
    Gereda JE, Klinnert MD, Price MR, Leung DY, Liu AH. Metropolitan home living conditions associated with indoor endotoxin levels. J Allergy Clin Immunol 2001;107: 790796.
  • 6
    Heinrich J, Gehring U, Douwes J, Koch A, Fahlbusch B, Bischof W et al. Pets and vermin are associated with high endotoxin levels in house dust. Clin Exp Allergy 2001;31: 18391845.
  • 7
    Park JH, Gold DR, Spiegelman DL, Burge HA, Milton DK. House dust endotoxin and wheeze in the first year of life. Am J Respir Crit Care Med 2001;163: 322328.
  • 8
    Michel O, Kips J, Duchateau J, Vertongen F, Robert L, Collet H et al. Severity of asthma is related to endotoxin in house dust. Am J Respir Crit Care Med 1996;154: 16411646.
  • 9
    Michel O, Ginanni R, Duchateau J, Vertongen F, Le Bon B, Sergysels R. Domestic endotoxin exposure and clinical severity of asthma. Clin Exp Allergy 1991;21: 441448.
  • 10
    Rizzo MC, Naspitz CK, Fernández-Caldas E, Locky RF, Mimica ISD. Endotoxin exposure and symptoms in asthmatic children. Pediatr Allergy Immunol 1997;8: 121126.
  • 11
    Braback L, Kjellman NI, Sandin A, Bjorksten B. Atopy among schoolchildren in northern and southern Sweden in relation to pet ownership and early life events. Pediatr Allergy Immunol 2001;12: 410.
  • 12
    Braun-Fahrlander C. Allergic diseases in farmers’ children. Pediatr Allergy Immunol 2000;11(Suppl. 13):1922.
  • 13
    Hesselmar B, Aberg N, Aberg B, Eriksson B, Bjorksten B. Does early exposure to cat or dog protect against later allergy development? Clin Exp Allergy 1999;29: 611617.
  • 14
    Riedler J, Braun-Fahrländer C, Eder W, Schreuer M, Waser M, Maisch S et al. Exposure to farming in early life and development of asthma and allergy: a cross-sectional survey. Lancet 2001;358: 11291133.
  • 15
    Riedler J, Eder W, Oberfeld G, Schreuer M. Austrian children living on a farm have less hay fever, asthma and allergic sensitization. Clin Exp Allergy 2000;30: 194200.
  • 16
    Von Ehrenstein OS, von Mutius E, Illi S, Baumann L, Bohm O, von Kries R. Reduced risk of hay fever and asthma among children of farmers. Clin Exp Allergy 2000;30: 187193.
  • 17
    Filipiak B, Heinrich J, Schafer T, Ring J, Wichmann HE. Farming, rural lifestyle and atopy in adults from southern Germany – results from the MONICA/KORA study Augsburg. Clin Exp Allergy 2001;31: 18291838.
  • 18
    Kauffmann F, Oryszczyn MP, Maccario J. The protective role of country living on skin prick tests, immunoglobulin E and asthma in adults from the epidemiological study on the genetics and environment of asthma, bronchial hyper-responsiveness and atopy. Clin Exp Allergy 2002;32: 379386.
  • 19
    Kilpelainen M, Terho EO, Helenius H, Koskenvuo M. Farm environment in childhood prevents the development of allergies. Clin Exp Allergy 2000;30: 201208.
  • 20
    Leynaert B, Neukirch C, Jarvis D, Chinn S, Burney P, Neukirch F. Does living on a farm during childhood protect against asthma, allergic rhinitis, and atopy in adulthood? Am J Respir Crit Care Med 2001;164: 18291834.
  • 21
    Portengen L, Sigsgaard T, Omland O, Hjort C, Heederik D, Doekes G. Low prevalence of atopy in young Danish farmers and farming students born and raised on a farm. Clin Exp Allergy 2002;32: 247253.
  • 22
    Roost HP, Kunzli N, Schindler C, Jarvis D, Chinn S, Perruchoud AP et al. Role of current and childhood exposure to cat and atopic sensitization. European Community Respiratory Health Survey. J Allergy Clin Immunol 1999;104: 941947.
  • 23
    Svanes C, Jarvis D, Chinn S, Burney P. Childhood environment and adult atopy: results from the European Community Respiratory Health Survey. J Allergy Clin Immunol 1999;103: 415420.
  • 24
    Litonjua AA, Milton DK, Celedon JC, Ryan L, Weiss ST, Gold DR. A longitudinal analysis of wheezing in young children: the independent effects of early life exposure to house dust endotoxin, allergens, and pets. J Allergy Clin Immunol 2002;110: 736742.
  • 25
    Gereda JE, Leung DY, Thatayatikom A, Streib JE, Price MR, Klinnert MD et al. Relation between house-dust endotoxin exposure, type 1 T-cell development, and allergen sensitisation in infants at high risk of asthma. Lancet 2000;355: 16801683.
  • 26
    Braun-Fahrlander C, Riedler J, Herz U, Eder W, Waser M, Grize L et al. Environmental exposure to endotoxin and its relation to asthma in school-age children. N Engl J Med 2002;347: 869877.
  • 27
    Gehring U, Bischof W, Fahlbusch B, Wichmann HE, Heinrich J. House dust endotoxin and allergic sensitization in children. Am J Respir Crit Care Med 2002;166: 939944.
  • 28
    Heinrich J, Nowak D, Wassmer G, Jorres R, Wjst M, Berger J et al. Age-dependent differences in the prevalence of allergic rhinitis and atopic sensitization between an eastern and a western German city. Allergy 1998;53: 8993.
  • 29
    Nowak D, Heinrich J, Jorres R, Wassmer G, Berger J, Beck E et al. Prevalence of respiratory symptoms, bronchial hyperresponsiveness and atopy among adults: west and east Germany. Eur Respir J 1996;9: 25412552.
  • 30
    Burney PG, Luczynska C, Chinn S, Jarvis D. The European Community Respiratory Health Survey. Eur Respir J 1994;7: 954960.
  • 31
    Platts-Mills TA, Thomas WR, Aalberse RC, Vervloet D, Chapman MD. Dust mite allergens and asthma: report of the second international workshop. J Allergy Clin Immunol 1992;89: 10461060.
  • 32
    Fahlbusch B, Heinrich J, Gross I, Jager L, Richter K, Wichmann HE. Allergens in house-dust samples in Germany: results of an east-west German comparison. Allergy 1999;54: 12151222.
  • 33
    Hastie T, Tibshirani R. Generalized additive models. London: Chapmann and Hall, 1990.
  • 34
    Hosmer DW, Lemeshow S. Applied logistic regression. New York: Wiley, 1989.
  • 35
    Kilpelainen M, Terho EO, Helenius H, Koskenvuo M. Childhood farm environment and asthma and sensitization in young adulthood. Allergy 2002;57: 11301135.
  • 36
    Heinrich J, Holscher B, Douwes J, Richter K, Koch A, Bischof W et al. Reproducibility of allergen, endotoxin and fungi measurements in the indoor environment. J Expo Anal Environ Epidemiol 2003;13: 152160.
  • 37
    Su HJ, Wu PC, Chen HL, Lee FC, Lin LL. Exposure assessment of indoor allergens, endotoxin, and airborne fungi for homes in southern Taiwan. Environ Res 2001;85: 135144.
  • 38
    Gassner-Bachmann M, Wuthrich B. Farmers’ children suffer less from hay fever and asthma. Dtsch Med Wochenschr 2000;125: 924931.