• 1
    Bousquet J, van Cauwenberge P, Khaltaev N, and the Workshop Expert Panel. Allergic Rhinitis and its impact on asthma (ARIA). Executive summary of the workshop report. Allergy 2002;57: 841855.
  • 2
    Malling H. Immunotherapy as an effective tool in allergy treatment. Allergy 1998;53: 461472.
  • 3
    Noon L, Cantab B. Prophylactic inoculation against hay fever. Lancet 1911;1: 15721574.
  • 4
    Bousquet J, Lockey R, Malling H, and the WHO Panel Members. Allergen immunotherapy: therapeutic vaccines for allergic diseases. WHO Position Paper. J Allergy Clin Immunol 1998;102: 558562.
  • 5
    Joint Task Force. Practice parameters for allergen immunotherapy. J Allergy Clin Immunol 1996;98: 10011011.
  • 6
    Des Roches A, Paradis L, Menardo J, Bouges S, Daures J, Bousquet J. Immunotherapy with Dermatophagoides pteronyssinus extract. VI. Specific immunotherapy prevents the onset of new sensitizations in children. J Allergy Clin Immunol 1997;99: 450453.
  • 7
    Möller C, Dreborg S, Ferdousi H, Halken S, Host A, Jacobsen L et al. Pollen immunotherapy reduces the development of asthma in children with seasonal rhinoconjunctivitis (the PAT-Study). J Allergy Clin Immunol 2002;109: 251256.
  • 8
    Pajno G, Barbiero G, De Luca F, Morabito L, Parmiani S. Prevention of new sensitizations in asthmatic children monosensitized to house dust mite by specific immunotherapy. A six-year follow-up study. Clin Exp Allergy 2001;31: 13921397.
  • 9
    Malling H. Is sublingual immunotherapy clinically effective? Curr Opin Allergy Clin Immunol 2002;2: 523531.
  • 10
    Wilson D, Torres Lima M, Durham S. Sublingual immunotherapy for allergic rhinitis (Cochrane Review). In: The Cochrane Library, Vol. 2. Oxford: Update Software, 2003.
  • 11
    Canonica G, Passalacqua G. Noninjection routes for immunotherapy. J Allergy Clin Immunol 2003;111: 437448.
  • 12
    Clavel R, Bousquet J, André C. Clinical efficacy of sublingual-swallow immunotherapy: a double-blind, placebo-controlled trial of a standardized five-grass-pollen extract in rhinitis. Allergy 1998;53: 493498.
  • 13
    Hordijk G, Antvelink J, Luwema R. Sublingual immunotherapy with a standardised grass pollen extract; a double-blind placebo-controlled study. Allergol Et Immunopathol 1998;26: 234240.
  • 14
    Pradalier A, Basset D, Claudel A, Couturier P, Wessel F, Galvain S et al. Sublingual-swallow immunotherapy (SLIT) with a standardized five-grass-pollen extract (drops and sublingual tablets) versus placebo in seasonal rhinitis. Allergy 1999;54: 819828.
  • 15
    Caffarelli C, Sensi L, Marcucci F, Cavagni G. Preseasonal local allergoid immunotherapy to grass pollen in children: a double-blind, placebo-controlled, randomized trial. Allergy 2000;55: 11421147.
  • 16
    Lima M, Wilson D, Pitkin L, Roberts A, Nouri-Aria K, Jacobson M et al. Grass pollen sublingual immunotherapy for seasonal rhinoconjunctivitis: a randomized controlled trial. Clin Exp Allergy 2002;32: 507514.
  • 17
    Sabbah A, Hassoun S, Le Sellin J, André C, Sicard H. A double-blind, placebo-controlled trial by the sublingual route of immunotherapy with a standardized grass pollen extract. Allergy 1994;49: 309313.
  • 18
    Feliziani V, Lattuada G, Parmiani S, Dall Aglio P. Safety and efficacy of sublingual rush immunotherapy with grass allergen extracts. A double blind study. Allergol Immunopathol 1995;23: 224230.
  • 19
    Malling H, Weeke B. Position paper: immunotherapy, EAACI immunotherapy subcommittee. Allergy 1993;48: 735.
  • 20
    Mattes J, Storm van's Gravesande K, Reining U, Alving K, Ihorst G, Henschen M et al. NO in exhaled air is correlated with markers of eosinophilic airway inflammation in corticosteroid-dependent childhood asthma. Eur Respir J 1999;13: 13911395.
  • 21
    European Task Force on Atopic dermatitis. Severity score of atopic dermatitis: the SCORAD index (consensus report of the European Task Force on atopic dermatitis). Dermatology 1993;186: 2331.
  • 22
    O'Brien P. Procedures for comparing samples with multiple endpoints. Biometrics 1984;40: 10791087.
  • 23
    Lehmacher W, Wassmer G, Reitmeir P. Procedures for two-sample comparisons with multiple endpoints controlling the experimentwise error rate. Biometrics 1991;47: 511521.
  • 24
    Bahceciler N, Isik U, Barlan I, Basaran M. Efficacy of sublingual immunotherapy in children with asthma and rhinitis: a double-blind, placebo-controlled study. Pediatr Pulmonol 2001;32: 4955.
  • 25
    Hirsch T, Sahn M, Leupold W. Double-blind placebo-controlled study of sublingual immunotherapy with house dust mite extract (D. pt.) in children. Ped Allergy Immunol 1997;8: 2127.
  • 26
    La Rosa M, Ranno C, André C, Carat F, Tosca M, Canonica G. Double-blind placebo-controlled evaluation of sublingual-swallow immunotherapy with standardized Parietaria judaica extract in children with allergic rhinoconjunctivitis. J Allergy Clin Immunol 2000;104: 425432.
  • 27
    Vourdas D, Syrigou E, Potamianou P, Carat F, Batard T, André C et al. Double-blind, placebo-controlled evaluation of sublingual immunotherapy with standardized olive pollen extract in pediatric patients with allergic rhinoconjunctivitis and mild asthma due to olive pollen sensitization. Allergy 1998;53: 662672.
  • 28
    Quirino T, Lemoli E, Siciliani E, Parmiani S, Milazzo F. Sublingual versus injective immunotherapy in grass pollen allergic patients: a double blind (double dummy) study. Clin Exp Allergy 1996;26: 12531261.
  • 29
    Passalacqua G, Albano M, Riccio A, Fregonese L, Puccinelli P, Parmiani S et al. Clinical and immunologic effects of a rush sublingual immunotherapy to Parietaria species: A double-blind, placebo-controlled trial. J Allergy Clin Immunol 1999;104: 964968.
  • 30
    Varney V, Gaga M, Frew A, Aber V, Kay A, Durham S. Usefulness of immunotherapy in patients with severe summer hay fever uncontrolled by antiallergic drugs. Br Med J 1991;302: 265269.
  • 31
    Durham S, Walker S, Varga E, Jacobson M, O'Brien F, Noble W et al. Long-term clinical efficacy of grass-pollen immunotherapy. N Engl J Med 1999;341: 468475.
  • 32
    Khinchi M, Poulsen L, Carat F, André C, Hansen A, Malling H. Clinical efficacy of sublingual and subcutaneous birch pollen allergen-specific immunotherapy: a randomized, placebo-controlled, double-blind, double-dummy study. Allergy 2004;58: 4553.
  • 33
    Passalacqua G, Canonica G. Sublingual or injection immunotherapy: the final answer? Allergy 2004;59: 3738.
  • 34
    Adkinson N. Immunotherapy for allergic rhinitis. N Engl J Med 1999;341: 522524.