ENDA: European Network of Drug Allergy, the EAACI interest group on drug hypersensitivity with the following additional members: Drs W. Aberer, B.K. Ballmer-Weber, M.B. Bilo, J. Birnbaum, M. Blanca, B. Blõmecke, P. Campi, A. de Weck, M. Drouet, C. Dzviga, J. Fernandez, E. Gomez, A. Kapp, M. Kidon, M. Kowalski, D. Laroche, G. Marone, M. Mertès, H. Merk, D.A. Moneret-Vautrin, C. Pascual-Marcos, E. Rebelo-Gomes, F. Rueff, M.L. Sanz, M.J. Torres, D. Vervloet, B. Wedi.
Management of hypersensitivity reactions to iodinated contrast media
Article first published online: 11 JAN 2005
Volume 60, Issue 2, pages 150–158, February 2005
How to Cite
Brockow, K., Christiansen, C., Kanny, G., Clément, O., Barbaud, A., Bircher, A., DeWachter, P., Guéant, J.-L., Rodriguez Guéant, R.-M., Mouton-Faivre, C., Ring, J., Romano, A., Sainte-Laudy, J., Demoly, P., Pichler, W. J., ENDA and the EAACI interest group on drug hypersensitivity (2005), Management of hypersensitivity reactions to iodinated contrast media. Allergy, 60: 150–158. doi: 10.1111/j.1398-9995.2005.00745.x
- Issue published online: 11 JAN 2005
- Article first published online: 11 JAN 2005
- Accepted for publication 6 August 2004
- contrast media;
- immediate reaction;
- nonimmediate reaction;
- skin tests
All iodinated contrast media (CM) are known to cause both immediate (≤1 h) and nonimmediate (>1 h) hypersensitivity reactions. Although for most immediate reactions an allergic hypersensitivity cannot be demonstrated, recent studies indicate that the severe immediate reactions may be IgE-mediated, while most of the nonimmediate exanthematous skin reactions, appear to be T-cell mediated. Patients who experience such hypersensitivity reactions are therefore advised to undergo an allergologic evaluation. Several investigators have found skin testing to be useful in confirming a CM allergy, especially in patients with nonimmediate skin eruptions. If a patient with confirmed allergy to a CM needs a new CM exposure, a skin test negative CM should be chosen and premedication may be tried. However, none of these precautional measures is a guarantee against a repeat reaction. More research focusing on pathomechanisms, diagnostic testing and premedication is therefore clearly needed in order to prevent CM-induced hypersensitivity reactions in the future.