You have full text access to this OnlineOpen article

Management of hypersensitivity reactions to iodinated contrast media

  1. K. Brockow1,
  2. C. Christiansen2,
  3. G. Kanny3,
  4. O. Clément4,
  5. A. Barbaud5,
  6. A. Bircher6,
  7. P. DeWachter7,
  8. J.-L. Guéant8,
  9. R.-M. Rodriguez Guéant8,
  10. C. Mouton-Faivre7,
  11. J. Ring1,
  12. A. Romano9,
  13. J. Sainte-Laudy10,
  14. P. Demoly11,
  15. W. J. Pichler12,
  16. ENDA†,
  17. the EAACI interest group on drug hypersensitivity1

Article first published online: 11 JAN 2005

DOI: 10.1111/j.1398-9995.2005.00745.x

Issue

Allergy

Allergy

Volume 60, Issue 2, pages 150–158, February 2005

Additional Information

How to Cite

Brockow, K., Christiansen, C., Kanny, G., Clément, O., Barbaud, A., Bircher, A., DeWachter, P., Guéant, J.-L., Rodriguez Guéant, R.-M., Mouton-Faivre, C., Ring, J., Romano, A., Sainte-Laudy, J., Demoly, P., Pichler, W. J., ENDA and the EAACI interest group on drug hypersensitivity (2005), Management of hypersensitivity reactions to iodinated contrast media. Allergy, 60: 150–158. doi: 10.1111/j.1398-9995.2005.00745.x

Author Information

  1. 1

    Klinik und Poliklinik für Dermatologie und Allergologie am Biederstein, Muenchen, Germany

  2. 2

    Research and Development, Amersham Health AS, Oslo, Norway, now part of GE Healthcare

  3. 3

    Department of Internal Medicine, Clinical Immunology and Allergy, University Hospital, Hospital Central, Nancy

  4. 4

    Service de Radiologie, Hôspital Europeen G. Pompidou, Paris

  5. 5

    Department of Dermatology, Fournier Hospital, Nancy, France

  6. 6

    Allergy Unit, Department of Dermatology, University Hospital, Basel, Switzerland

  7. 7

    Departement d'Anesthesie-Réanimation, Hospital Central, Nancy

  8. 8

    Laboratoire de Pathologie Cellulaire et Moléculaire en Nutrition, Faculté de Médecine de Nancy, France

  9. 9

    Department of Internal Medicine and Geriatrics, UCSC, Allergy Unit, C.I. Columbus, Rome and IRCCS Oasi Maria S.S., Troina, Italy

  10. 10

    Laboratoire d'Immunologie et d'Allergologie, Paris

  11. 11

    Exploration des Allergies – Maladies Respiratoires – INSERM U454, Hôpital Arnaud de Villeneuve, Montpellier, France

  12. 12

    Clinic for Rheumatology and Clinical Immunology/Allergology, Inselspital, Bern, Switzerland

  1. †

    ENDA: European Network of Drug Allergy, the EAACI interest group on drug hypersensitivity with the following additional members: Drs W. Aberer, B.K. Ballmer-Weber, M.B. Bilo, J. Birnbaum, M. Blanca, B. Blõmecke, P. Campi, A. de Weck, M. Drouet, C. Dzviga, J. Fernandez, E. Gomez, A. Kapp, M. Kidon, M. Kowalski, D. Laroche, G. Marone, M. Mertès, H. Merk, D.A. Moneret-Vautrin, C. Pascual-Marcos, E. Rebelo-Gomes, F. Rueff, M.L. Sanz, M.J. Torres, D. Vervloet, B. Wedi.

*Knut Brockow Department of Dermatology and Allergy Biederstein Technical University Munich Biedersteiner Strasse 29, 80802 Munich Germany

  • †

    ENDA: European Network of Drug Allergy, the EAACI interest group on drug hypersensitivity with the following additional members: Drs W. Aberer, B.K. Ballmer-Weber, M.B. Bilo, J. Birnbaum, M. Blanca, B. Blõmecke, P. Campi, A. de Weck, M. Drouet, C. Dzviga, J. Fernandez, E. Gomez, A. Kapp, M. Kidon, M. Kowalski, D. Laroche, G. Marone, M. Mertès, H. Merk, D.A. Moneret-Vautrin, C. Pascual-Marcos, E. Rebelo-Gomes, F. Rueff, M.L. Sanz, M.J. Torres, D. Vervloet, B. Wedi.

Publication History

  1. Issue published online: 11 JAN 2005
  2. Article first published online: 11 JAN 2005
  3. Accepted for publication 6 August 2004

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (131K)

Keywords:

  • contrast media;
  • diagnosis;
  • immediate reaction;
  • nonimmediate reaction;
  • premedication;
  • skin tests

All iodinated contrast media (CM) are known to cause both immediate (≤1 h) and nonimmediate (>1 h) hypersensitivity reactions. Although for most immediate reactions an allergic hypersensitivity cannot be demonstrated, recent studies indicate that the severe immediate reactions may be IgE-mediated, while most of the nonimmediate exanthematous skin reactions, appear to be T-cell mediated. Patients who experience such hypersensitivity reactions are therefore advised to undergo an allergologic evaluation. Several investigators have found skin testing to be useful in confirming a CM allergy, especially in patients with nonimmediate skin eruptions. If a patient with confirmed allergy to a CM needs a new CM exposure, a skin test negative CM should be chosen and premedication may be tried. However, none of these precautional measures is a guarantee against a repeat reaction. More research focusing on pathomechanisms, diagnostic testing and premedication is therefore clearly needed in order to prevent CM-induced hypersensitivity reactions in the future.

View Full Article (HTML) Get PDF (131K)