• 1
    Strachan D. Allergy and family size: a riddle worth solving (Editorial). Clin Exp Allergy 1997;27: 235236.
  • 2
    Yazdanbakhsh M, Kremsner P, van Ree R. Allergy, parasites, and the hygiene hypothesis. Science 2002;296: 490494.
  • 3
    Liu A, Murphy J. Hygiene hypothesis: fact or fiction? J Allergy Clin Immunol 2003;111: 471478.
  • 4
    Pritchard D. Atopy and helminthic parasites. Int J Parasitol 1993;23: 167168.
  • 5
    Scrivener S, Yemaneberhan H, Zebenigus M, Tilahun D, Girma S, Ali S et al. Independent effects of intestinal parasite infection and domestic allergen exposure on risk of wheeze in Ethiopia: a nested case–control study. Lancet 2001;358: 14931499.
  • 6
    Cooper P, Chico M, Bland M, Griffin G, Nutman T. Allergic symptoms, atopy, and geohelminth infections in a rural area of Ecuador. Am J Respir Crit Care Med 2003;168: 313317.
  • 7
    Cooper P, Chico M, Rodrigues L, Ordonez M, Strachan D, Griffin G et al. Reduced risk of atopy among school-age children infected with geohelminth parasites in a rural area of the tropics. J Allergy Clin Immunol 2003;111: 9951000.
  • 8
    Dagoye D, Bekele Z, Woldemichael K, Nida H, Yimam M, Hall A et al. Wheezing, allergy, and parasite infection in children in urban and rural Ethiopia. Am J Respir Crit Care Med 2003;167: 13691373.
  • 9
    Lynch N, Hagel I, Palenque M, Di Prisco M, Escudero J, Corao L et al. Relationship between helminthic infection and IgE response in atopic and nonatopic children in a tropical environment. J Allergy Clin Immunol 1998;101: 217221.
  • 10
    Perzanowski M, Ng'ang'a L, Carter M, Odhiambo J, Ngari P, Vaughan J et al. Atopy, asthma, and antibodies to Ascaris among rural and urban children in Kenya. J Pediatr 2002;140: 582588.
  • 11
    van Hertzen L, Haahtela T. Asthma and atopy – the process of affluence. Allergy 2004;59: 124137.
  • 12
    Flohr C. Dirt, worms and atopic dermatitis. Br J Dermatol 2003;148: 871877.
  • 13
    Huang S, Tsai P, Yeh Y. Negative association of Enterobius infestation with asthma and rhinitis in primary school children in Taipei. Clin Exp Allergy 2002;32: 10291032.
  • 14
    Heinrich J, Hoelscher B, Frye C, Meyer I, Pitz M, Cyrys J et al. Improved air quality in reunified Germany and decreases in respiratory symptoms. Epidemiology 2002;13: 394401.
  • 15
    Heinrich J, Hoelscher B, Wichmann H. Decline of ambient air pollution and respiratory symptoms in children. Am J Respir Crit Care Med 2000;161: 19301936.
  • 16
    Meyer I, Heinrich J, Lippold U. Factors affecting lead, cadmium, and arsenic levels in house dust in a smelter town in Eastern Germany. Environ Res 1999;81: 3244.
  • 17
    Keil U, Weiland S, Duhme H, Chambless L. The international study of asthma and allergies in childhood (ISAAC): objectives and methods; results from German ISAAC centres concerning traffic density and wheezing and allergic rhinitis. Toxicol Lett 1996;86: 99103.
  • 18
    Williams H, Burney P, Pembroke A, Hay R. The U.K. working party's diagnostic criteria for atopic dermatitis. III. Independent hospital validation. BJD 1994;131: 406416.
  • 19
    Möhrenschlager M, Schäfer T, Williams H, Werth der van J, Krämer U, Behrendt H et al. Übersetzung und Validierung der britischen Diagnosekriterien des atopischen Ekzems bei acht- und neunjährigen Schulkindern in Augsburg 1998. Allergo J 1998;7: 375377.
  • 20
    Williams H, Burney P, Hay R, Archer C, Shipley M, Hunter J et al. The U.K. working party's diagnostic criteria for atopic dermatitis. I. Derivation of a minimum set of discriminators for atopic dermatitis. BJD 1994;131: 383396.
  • 21
    Williams H, Burney P, Strachan D, Hay R. The U.K. working party's diagnostic criteria for atopic dermatitis. II. Observer variation of clinical diagnosis and signs of atopic dermatitis. BJD 1994;131: 397405.
  • 22
    van den Biggelaar A, Rodrigues L, van Ree R, van der Zee J, Hoeksma-Kruize Y, Souverijn J et al. Long-term treatment of intestinal helminths increases mite skin-test reactivity in Gabonese schoolchildren. J Infect Dis 2004;189: 892900.
  • 23
    Larrick J, Buckley C, Machamer C, Schlagel G, Yosts J, Blessign-Moore J et al. Does hyperimmunoglobulinemia-E protect tropical populations from allergic diseases? J Allergy Clin Immunol 1983;71: 184188.
  • 24
    Lynch N, Lopez R, Isturiz G, Tenias-Salazar E. Allergic reactivity and helminthic infection in Amerindians of the Amazon Basin. Int Arch Allergy Appl Immunol 1983;72: 369372.
  • 25
    Lynch N, Goldblatt J, Le Souef P. Parasite infections and the risk of asthma and atopy. Thorax 1999;54: 659660.
  • 26
    van den Biggelaar A, van Ree R, Rodrigues L, Lell B, Deelder A, Kremsner P et al. Decreased atopy in children infected with Schistosoma haematobium: a role for parasite-induced interleukin-10. Lancet 2000;356: 17231727.
  • 27
    Dold S, Heinrich J, Wichmann H, Wjst M. Ascaris-specific IgE and allergic sensitization in a cohort of school children in the former East Germany. J Allergy Clin Immunol 1998;102: 414420.
  • 28
    Behrendt H, Krämer U, Dolgner R, Hinrichs J, Willer H, Hagenbeck H. Elevated levels of total serum IgE in East German children: atopy, parasites or pollutants? Allergo J 1993;3: 3140.
  • 29
    Schäfer T, Vieluf D, Behrendt H, Krämer U, Ring J. Atopic eczema and other manifestations of atopy: results of a study in East and West Germany. Allergy 1996;51: 532539.
  • 30
    Krämer U, Behrendt H, Dolgner R, Ranft U, Ring J, Willer H et al. Airway diseases and allergies in East and West German children during the first five years after reunification: time trends and the impact of sulphur dioxide and total suspended particles. Int J Epidemiol 1999;28: 865873.
  • 31
    Heinrich J, Hölscher B, Frye C, Meyer I, Wjst M, Wichmann H. Trends in prevalence of atopic diseases and allergic sensitisation in children in East Germany. Eur Resp J 2002;19: 10401046.
  • 32
    Schäfer T, Krämer U, Vieluf D, Abeck D, Behrendt H, Ring J. The excess of atopic eczema in East Germany is related to the intrinsic type. Br J Dermatol 2000;143: 992998.
  • 33
    Wichmann H. Environment, life-style and allergy: the German answer. Allergo J 1995;6: 315316.