A new tool to evaluate the impact of chronic urticaria on quality of life: chronic urticaria quality of life questionnaire (CU-Q2oL)
Article first published online: 21 JUN 2005
Volume 60, Issue 8, pages 1073–1078, August 2005
How to Cite
Baiardini, I., Pasquali, M., Braido, F., Fumagalli, F., Guerra, L., Compalati, E., Braga, M., Lombardi, C., Fassio, O. and Canonica, G. W. (2005), A new tool to evaluate the impact of chronic urticaria on quality of life: chronic urticaria quality of life questionnaire (CU-Q2oL). Allergy, 60: 1073–1078. doi: 10.1111/j.1398-9995.2005.00833.x
- Issue published online: 21 JUN 2005
- Article first published online: 21 JUN 2005
- Accepted for publication 27 January 2005
- disease specific questionnaire;
- quality of life;
Background: Health-related quality of Life in patients with chronic urticaria is evaluated by mean of generic instruments or questionnaire designed for skin diseases. No disease-specific tool is now available for the assessment of chronic urticaria impact from patients’ viewpoint.
Objective: The aim of our study is to develop and validate a new questionnaire specifically designed for the assessment of quality of life in chronic urticaria (Chronic Urticaria Quality of Life Questionnaire – CU-Q2oL)
Methods: In the development phase of CU-Q2oL an initial list of items of 37 items was compiled and given to 80 patients with chronic urticaria; the 23 most significant items were selected and converted into questions evaluating the answers on a Likert scale of five steps. The validation procedure involved 125 patients (86 F and 39 M) (age 42.17 ± 9.24 years).
Results: Following a statistical analysis, CU-Q2oL showed a six-dimensional structure and good levels of internal consistency for the extracted factors: Pruritus (0.79), Swelling (0.65), Impact on life activities (0.83), Sleep problems (0.77), Looks (0.83) and Limits (0.74). In stable conditions CU-Q2oL showed a good reliability, ranged between 0.64 and 0.92. Responsiveness to clinical changes was accomplished.
Discussion: These results provide evidence that CU-Q2oL has specificity enough for being a valid tool for detecting the relative burden of CU on subjective wellbeing, and for obtaining a global evaluation both of CU impact and of treatments, taking into account the patient's point of view. The CU-Q2oL was easily and quickly filled up and well accepted by the patients.