Prof. A. M. Vignola deceased on 22 December 2004.
Standard skin prick testing and sensitization to inhalant allergens across Europe – a survey from the GA2LEN network*
Version of Record online: 11 JUN 2005
Volume 60, Issue 10, pages 1287–1300, October 2005
How to Cite
Heinzerling, L., Frew, A. J., Bindslev-Jensen, C., Bonini, S., Bousquet, J., Bresciani, M., Carlsen, K.-H., van Cauwenberge, P., Darsow, U., Fokkens, W. J., Haahtela, T., van Hoecke, H., Jessberger, B., Kowalski, M. L., Kopp, T., Lahoz, C. N., Lodrup Carlsen, K. C., Papadopoulos, N. G., Ring, J., Schmid-Grendelmeier, P., Vignola, A. M., Wöhrl, S. and Zuberbier, T. (2005), Standard skin prick testing and sensitization to inhalant allergens across Europe – a survey from the GA2LEN network. Allergy, 60: 1287–1300. doi: 10.1111/j.1398-9995.2005.00895.x
The authors of this paper are partners in the Global Allergy and Asthma European Network (GA2LEN)
- Issue online: 31 AUG 2005
- Version of Record online: 11 JUN 2005
- Accepted for publication 15 April 2005
- European network;
- inhalant allergens;
- standard skin prick testing
Skin prick testing (SPT) is the standard method for diagnosing allergic sensitization but is to some extent performed differently in clinical centres across Europe. There would be advantages in harmonizing the standard panels of allergens used in different European countries, both for clinical purposes and for research, especially with increasing mobility within Europe and current trends in botany and agriculture. As well as improving diagnostic accuracy, this would allow better comparison of research findings in European allergy centres. We have compared the different SPT procedures operating in 29 allergy centres within the Global Allergy and Asthma European Network (GA2LEN). Standard SPT is performed similarly in all centres, e.g. using commercial extracts, evaluation after 15–20 min exposure with positive results defined as a wheal >3 mm diameter. The perennial allergens included in the standard SPT panel of inhalant allergens are largely similar (e.g. cat: pricked in all centres; dog: 26 of 29 centres and Dermatophagoides pteronyssinus: 28 of 29 centres) but the choice of pollen allergens vary considerably, reflecting different exposure and sensitization rates for regional inhalant allergens. This overview may serve as reference for the practising doctor and suggests a GA2LEN Pan-European core SPT panel.