• 1
    Demoly P, Romano A. Update on β-lactam allergy diagnosis. Curr Allergy Asthma Rep 2005;5:914.
  • 2
    Geha RS, Jabara HH, Brodeur SR. The regulation of immunoglobulin E class-switch recombination. Nat Rev Immunol 2003;3:721732.
  • 3
    Nelms K, Keegan AD, Zamorano J, Ryan JJ, Paul WE. The IL-4 receptor: signaling mechanisms and biologic functions. Annu Rev Immunol 1999;17:701738.
  • 4
    Pene J, Rousset F, Briere F, Chretien I, Paliard X, Banchereau J et al. IgE production by normal human B cells induced by alloreactive T cell clones is mediated by IL-4 and suppressed by IFN-gamma. J Immunol 1988;141:12181224.
  • 5
    Rosenwasser LJ, Klemm DJ, Dresback JK, Inamura H, Mascali JJ, Klinnert M et al. Promoter polymorphisms in the chromosome 5 gene cluster in asthma and atopy. Clin Exp Allergy 1995;25(Suppl. 2):7478.
  • 6
    Graves PE, Kabesch M, Halonen M, Holberg CJ, Baldini M, Fritzsch C et al. A cluster of seven tightly linked polymorphisms in the IL-13 gene is associated with total serum IgE levels in three populations of white children. J Allergy Clin Immunol 2000;105:506513.
  • 7
    Hershey GK, Friedrich MF, Esswein LA, Thomas ML, Chatila TA. The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor. N Engl J Med 1997;337:17201755.
  • 8
    Gao PS, Mao XQ, Jouanguy E, Pallier A, Doffinger R, Tanaka Y et al. Nonpathogenic common variants of IFNGR1 and IFNGR2 in association with total serum IgE levels. Biochem Biophys Res Commun 1999;263:425429.
  • 9
    Duetsch G, Illig T, Loesgen S, Rohde K, Klopp N, Herbon N et al. STAT6 as an asthma candidate gene: polymorphism-screening, association and haplotype analysis in a Caucasian sib-pair study. Hum Mol Genet 2002;11:613621.
  • 10
    Pykalainen M, Kinos R, Valkonen S, Rydman P, Kilpelainen M, Laitinen LA et al. Association analysis of common variants of STAT6, GATA3, and STAT4 to asthma and high serum IgE phenotypes. J Allergy Clin Immunol 2005;115:8087.
  • 11
    Moore KW, De Waal Malefyt R, Coffman RL, O'Garra A. Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol 2001;19:683765.
  • 12
    Turner DM, Williams DM, Sankaran D, Lazarus M, Sinnott PJ, Hutchinson IV. An investigation of polymorphism in the interleukin-10 gene promoter. Eur J Immunogenet 1997;24:18.
  • 13
    Reuss E, Fimmers R, Kruger A, Becker C, Rittner C, Hohler T. Differential regulation of interleukin-10 production by genetic and environmental factors – a twin study. Genes Immun 2002;3:407413.
  • 14
    Parrish-Novak J, Dillon SR, Nelson A, Hammond A, Sprecher C, Gross JA et al. Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature 2000;408:5763.
  • 15
    Ozaki K, Spolski R, Feng CG, Qi CF, Cheng J, Sher A et al. A critical role for IL-21 in regulating immunoglobulin production. Science 2002;298:16301634.
  • 16
    Wood N, Bourque K, Donaldson DD, Collins M, Vercelli D, Goldman SJ et al. IL-21 effects on human IgE production in response to IL-4 or IL-13. Cell Immunol 2004;231:133145.
  • 17
    Hecker M, Bohnert A, Konig IR, Bein G, Hackstein H. Novel genetic variation of human interleukin-21 receptor is associated with elevated IgE levels in females. Genes Immun 2003;4:228233.
  • 18
    Qiao HL, Yang J, Zhang YW. Specific serum IgE levels and FcɛRIβ genetic polymorphism in patients with penicillins allergy. Allergy 2004;59:13261332.
  • 19
    Qiao HL, Yang J, Zhang YW. Relationships between specific serum IgE, cytokines and polymorphisms in the IL-4, IL-4Rα in patients with penicillins allergy. Allergy 2005;60:10531059.
  • 20
    Mok CC, Lanchbury JS, Chan DW, Lau CS. Interleukin-10 promoter polymorphisms in southern Chinese patients with systemic lupus erythematosus. Arthritis Rheum 1998;41:10901095.
  • 21
    Haddi E, Charpin D, Tafforeau M, Kulling G, Lanteaume A, Kleisbauer JP et al. Atopy and systemic reactions to drugs. Allergy 1990;45:236239.
  • 22
    Asero R. Detection of patients with multiple drug allergy syndrome by elective tolerance tests. Ann Allergy Asthma Immunol 1998;8:185188.
  • 23
    Astarita C, Harris RI, De Fusco R, Franzese A, Biscardi D, Mazzacca FR et al. An epidemiological study of atopy in children. Clin Allergy 1988;18:341350.
  • 24
    Holloway JW, Beghe B, Holgate ST. The genetic basis of atopic asthma. Clin Exp Allergy 1999;29:10231032.
  • 25
    Mitsuyasu H, Yanagihara Y, Mao XQ, Gao PS, Arinobu Y, Ihara K et al. Cutting edge: dominant effect of Ile50Val variant of the human IL-4 receptor alpha-chain in IgE synthesis. J Immunol 1999;162:12271231.
  • 26
    Wang HY, Shelburne CP, Zamorano J, Kelly AE, Ryan JJ, Keegan AD. Cutting edge: effects of an allergy-associated mutation in the human IL-4R alpha (Q576R) on human IL-4-induced signal transduction. J Immunol 1999;162:43854389.
  • 27
    Risma KA, Wang N, Andrews RP, Cunningham CM, Ericksen MB, Bernstein JA et al. V75R576 IL-4 receptor alpha is associated with allergic asthma and enhanced IL-4 receptor function. J Immunol 2002;169:16041610.
  • 28
    Mitsuyasu H, Izuhara K, Mao XQ, Gao PS, Arinobu Y, Enomoto T et al. Ile50Val variant of IL4R alpha upregulates IgE synthesis and associates with atopic asthma. Nat Genet 1998;19:119120.
  • 29
    Fiorentino DF, Bond MW, Mosmann TR. Two types of mouse T helper cell: IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J Exp Med 1989;170:20812095.
  • 30
    Taga K, Tosato G. IL-10 inhibits human T cell proliferation and IL-2 production. J Immunol 1992;148:11431148.
  • 31
    De Waal Malefyt R, Abrams J, Bennett B, Figdor CG, De Vries JE. Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J Exp Med 1991;174:12091220.
  • 32
    Hawrylowicz CM, O'Garra A. Potential role of interleukin-10 secreting regulatory T cells in allergy and asthma. Nat Rev Immunol 2005;5:271283.
  • 33
    Barranco P, Lopez-Serrano MC. General and epidemiological aspects of allergic drug reactions. Clin Exp Allergy 1998;28(Suppl. 4):S6162.
  • 34
    Asero R. Detection of patients with multiple drug allergy syndrome by elective tolerance tests. Ann Allergy Asthma Immunol 1998;80:185188.