Members of and institutions affiliated with the LISA study group are listed in the Appendix.
Atopic eczema in children: another harmful sequel of divorce
Article first published online: 4 SEP 2006
Volume 61, Issue 12, pages 1397–1402, December 2006
How to Cite
Bockelbrink, A., Heinrich, J., Schäfer, I., Zutavern, A., Borte, M., Herbarth, O., Schaaf, B., Von Berg, A., Schäfer, T. and for the LISA Study Group (2006), Atopic eczema in children: another harmful sequel of divorce. Allergy, 61: 1397–1402. doi: 10.1111/j.1398-9995.2006.01186.x
- Issue published online: 4 SEP 2006
- Article first published online: 4 SEP 2006
- Accepted for publication 8 May 2006
- atopic eczema;
- life event;
Background: Different lifestyle factors seem to be associated with the risk for atopic diseases and some studies suggest that stress increases the risk of allergic sensitization, asthma and atopic eczema. Only few studies have investigated the association of early stressful life events and atopic eczema (AE) in children.
Subjects and Methods: Parents of participants of the ongoing LISA birth cohort study were asked to give information on life events, such as severe disease or death of a family member, unemployment, or divorce of the parents. Lifetime prevalence of AE and incidence after the assessment period for life events were compared.
Results: Prevalence of AE until the age of 4 years was 21.4%. Reported life events within the first 2 years were: severe disease (17.5%) or death (8.4%) of a family member, divorce/separation (3.4%), and unemployment (2.7%). Divorce/separation was associated with a significantly [odds ratio (OR) 3.59, 95% confidence interval (CI) 1.69–7.66] increased and disease with a significantly (OR 0.29, 95% CI 0.13–0.68) decreased incidence of AE for the subsequent 2 years of life. No effect was seen for unemployment.
Conclusions: Divorce/separation of the parents and severe disease of a family member influence the risk of developing AE.