Short communication: Public data mining shows extended linkage disequilibrium around ADAM33
Article first published online: 12 MAR 2007
Volume 62, Issue 4, pages 444–446, April 2007
How to Cite
Wjst, M. (2007), Short communication: Public data mining shows extended linkage disequilibrium around ADAM33. Allergy, 62: 444–446. doi: 10.1111/j.1398-9995.2006.01298.x
- Issue published online: 12 MAR 2007
- Article first published online: 12 MAR 2007
- Accepted for publication 15 November 2006
- disease mapping;
- linkage disequilibrium;
- positional cloning;
Background: ADAM33 has been described to be the first positional cloned asthma gene. Consecutive association studies have found inconsistent results. At present no functional relevant variation is being known.
Objective: Aim of the study was to test if genes in close physical distance could also be responsible for the observed linkage signal.
Method: We downloaded three public single-nucleotide polymorphism (SNP) data sets and tested if linkage disequilibrium extends beyond ADAM33.
Results: Linkage disequilibrium extends upstream to a region including GDNF family receptor alpha (GFRA4), attractin (ATRN) and downstream to sialoadhesin (SN) with a peak recombinatory rate at ADAM33 exon S to V.
Conclusion: Resequencing of the ADAM33 region including GFRA4, ATRN and SN is expedient.