The protective effect of rural living against atopy in Mongolia
Article first published online: 19 JAN 2007
Volume 62, Issue 3, pages 272–280, March 2007
How to Cite
Viinanen, A., Munhbayarlah, S., Zevgee, T., Narantsetseg, L., Naidansuren, Ts., Koskenvuo, M., Helenius, H. and Terho, E. O. (2007), The protective effect of rural living against atopy in Mongolia. Allergy, 62: 272–280. doi: 10.1111/j.1398-9995.2007.01279.x
- Issue published online: 19 JAN 2007
- Article first published online: 19 JAN 2007
- Accepted for publication 22 October 2006
- asthma hygiene hypothesis;
Background: Farm environment in childhood protects against atopy. We investigated in a population-based study in Mongolia the effects of rural living and migration from rural to urban areas on the risk of atopy.
Methods: The screening study data of 9453 subjects, aged 10–60 years, were used for taking the sample for the clinical study in which 869 subjects were examined. Asthma, allergic rhinoconjunctivitis and sensitization were clinically defined and their risk factors analysed by logistic regression.
Results: The risks of allergic rhinoconjunctivitis [adjusted odds ratio (OR) 0.43, 95% confidence interval (CI) 0.19–0.98] and allergic sensitization (OR 0.26, 95% CI 0.13–0.55) were the lowest in subjects living in a village from birth and intermediate in subjects who had relocated from a village to a town (OR for rhinoconjunctivitis 0.68, 95% CI 0.36–1.27, OR for sensitization 0.62, 95% CI 0.35–1.12) compared with subjects living in a town from birth. Simultaneous exposure to herd animals and dung heating decreased the risk of atopy. Keeping animals was a risk-factor for asthma only in Ulaanbaatar city.
Conclusions: Continuing farm exposure after childhood may be important in reducing the risk of atopy.