• 1
    Carlsen KC, Haland G, Devulapalli CS, Munthe-Kaas M, Pettersen M, Granum B et al. Asthma in every fifth child in Oslo, Norway: a 10-year follow up of a birth cohort study. Allergy 2006;61:454460.
  • 2
    Woolcock AJ, Peat JK. Evidence for the increase in asthma worldwide. Ciba Found Symp 1997;206:122134.
  • 3
    Koppelman GH, Los H, Postma DS. Genetic and environment in asthma: the answer of twin studies. Eur Respir J 1999;13:24.
  • 4
    NIH/WHO. Global strategy for asthma management and prevention: updated workshop report. Bethesda: NIH, 2005.
  • 5
    Venge P, Bystrom J, Carlson M, Hakansson L, Karawacjzyk M, Peterson C et al. Eosinophil cationic protein (ECP): molecular and biological properties and the use of ECP as a marker of eosinophil activation in disease. Clin Exp Allergy 1999;29:11721186.
  • 6
    Wolthers OD. Eosinophil granule proteins in the assessment of airway inflammation in pediatric bronchial asthma. Pediatr Allergy Immunol 2003;14:248254.
  • 7
    Matsumoto H, Niimi A, Minakuchi M, Izumi T. Serum eosinophil cationic protein levels measured during exacerbation of asthma: characteristics of patients with low titres. Clin Exp Allergy 2001;31:637643.
  • 8
    Wolthers OD, Heuck C. Circadian variations in serum eosinophil cationic protein, and serum and urine eosinophil protein X. Pediatr Allergy Immunol 2003;14:130133.
  • 9
    Hoekstra MO. Can eosinophil-derived proteins be used to diagnose or to monitor childhood asthma? Clin Exp Allergy 1999;29:873874.
  • 10
    Venge P. Monitoring the allergic inflammation. Allergy 2004;59:2632.
  • 11
    Noguchi E, Iwama A, Takeda K, Takeda T, Kamioka M, Ichikawa K et al. The promoter polymorphism in the eosinophil cationic protein gene and its influence on the serum eosinophil cationic protein level. Am J Respir Crit Care Med 2003;167:180184.
  • 12
    Zhang J, Rosenberg HF. Sequence variation at two eosinophil-associated ribonuclease loci in humans. Genetics 2000;156:19491958.
  • 13
    Young JD, Peterson CG, Venge P, Cohn ZA. Mechanism of membrane damage mediated by human eosinophil cationic protein. Nature 1986;321:613616.
  • 14
    Carreras E, Boix E, Rosenberg HF, Cuchillo CM, Nogues MV. Both aromatic and cationic residues contribute to the membrane-lytic and bactericidal activity of eosinophil cationic protein. Biochemistry 2003;42:66366644.
  • 15
    Zagai U, Skold CM, Trulson A, Venge P, Lundahl J. The effect of eosinophils on collagen gel contraction and implications for tissue remodelling. Clin Exp Immunol 2004;135:427433.
  • 16
    Hohlfeld JM, Schmiedl A, Erpenbeck VJ, Venge P, Krug N. Eosinophil cationic protein alters pulmonary surfactant structure and function in asthma. J Allergy Clin Immunol 2004;113:496502.
  • 17
    Jonsson UB, Bystrom J, Stalenheim G, Venge P. Polymorphism of the eosinophil cationic protein-gene is related to the expression of allergic symptoms. Clin Exp Allergy 2002;32:10921095.
  • 18
    Jonsson UB, Bystrom J, Stalenheim G, Venge P. A (G->C) transversion in the 3′ UTR of the human ECP (eosinophil cationic protein) gene correlates to the cellular content of ECP. J Leukoc Biol 2006;79:846851.
  • 19
    Hakonarson H, Bjornsdottir US, Halapi E, Palsson S, Adalsteinsdottir E, Gislason D et al. A major susceptibility gene for asthma maps to chromosome 14q24. Am J Hum Genet 2002;71:483491.
  • 20
    Hirasawa R, Shimizu R, Takahashi S, Osawa M, Takayanagi S, Kato Y et al. Essential and instructive roles of GATA factors in eosinophil development. J Exp Med 2002;195:13791386.
  • 21
    Merika M, Orkin SH. DNA-binding specificity of GATA family transcription factors. Mol Cell Biol 1993;13:39994010.
  • 22
    Handen JS, Rosenberg HF. Intronic enhancer activity of the eosinophil-derived neurotoxin (RNS2) and eosinophil cationic protein (RNS3) genes is mediated by an NFAT-1 consensus binding sequence. J Biol Chem 1997;272:16651669.
  • 23
    Munthe-Kaas MC, Carlsen KH, Helms PJ, Gerritsen J, Whyte M, Feijen M et al. CTLA-4 polymorphisms in allergy and asthma and the TH1/ TH2 paradigm. J Allergy Clin Immunol 2004;114:280287.
  • 24
    American Thoracic Society. Lung function testing: selection of reference values and interpretative strategies. Am Rev Respir Dis 1991;144:12021218.
  • 25
    Crapo RO, Morris AH, Gardner RM. Reference spirometric values using techniques and equipment that meet ATS recommendations. Am Rev Respir Dis 1981;123:659664.
  • 26
    Wang X, Dockery DW, Wypij D, Gold DR, Speizer FE, Ware JH et al. Pulmonary function growth velocity in children 6 to 18 years of age. Am Rev Respir Dis 1993;148(6 Pt 1):15021508.
  • 27
    Dreborg S, Frew A. Allergen standardization and skin tests. Allergy 1993;48 (Suppl. 14):48S82S.
  • 28
    Lodrup Carlsen KC, Halvorsen R, Ahlstedt S, Carlsen KH. Eosinophil cationic protein and tidal flow volume loops in children 0–2 years of age. Eur Respir J 1995;8:11481154.
  • 29
    Peterson CG, Enander I, Nystrand J, Anderson AS, Nilsson L, Venge P. Radioimmunoassay of human eosinophil cationic protein (ECP) by an improved method. Establishment of normal levels in serum and turnover in vivo. Clin Exp Allergy 1991;21:561567.
  • 30
    Hargreave FE, Ryan G, Thomson NC, O'Byrne PM, Latimer K, Juniper EF et al. Bronchial responsiveness to histamine or methacholine in asthma: measurement and clinical significance. J Allergy Clin Immunol 1981;68:347355.
  • 31
    O'Connell JR, Weeks DE. PedCheck: a program for identification of genotype incompatibilities in linkage analysis. Am J Hum Genet 1998;63:259266.
  • 32
    Wigginton JE, Abecasis GR. PEDSTATS: descriptive statistics, graphics and quality assessment for gene mapping data. Bioinformatics 2005;21:34453447.
  • 33
    Ewens WJ, Spielman RS. The transmission/disequilibrium test: history, subdivision, and admixture. Am J Hum Genet 1995;57:455464.
  • 34
    Du J, Stankiewicz MJ, Liu Y, Xi Q, Schmitz JE, Lekstrom-Himes JA et al. Novel combinatorial interactions of GATA-1, PU.1, and C/EBPepsilon isoforms regulate transcription of the gene encoding eosinophil granule major basic protein. J Biol Chem 2002;277:4348143494.