Present address: Department of Medicine, McMaster University, Hamilton, ON, Canada.
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Airway expression of calcitonin gene-related peptide in T-cell peptide-induced late asthmatic reactions in atopics
Article first published online: 12 APR 2007
DOI: 10.1111/j.1398-9995.2007.01342.x
Additional Information
How to Cite
Kay, A. B., Ali, F. R., Heaney, L. G., Benyahia, F., Soh, C. P. C., Renz, H., Lee, T. H. and Larché, M. (2007), Airway expression of calcitonin gene-related peptide in T-cell peptide-induced late asthmatic reactions in atopics. Allergy, 62: 495–503. doi: 10.1111/j.1398-9995.2007.01342.x
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Present address: Department of Medicine, McMaster University, Hamilton, ON, Canada.
Publication History
- Issue published online: 12 APR 2007
- Article first published online: 12 APR 2007
- Accepted for publication 3 January 2007
References
- 1, , The role of T lymphocytes in the pathogenesis of asthma. J Allergy Clin Immunol 2003;111:450–463.
- 2, , IgE-independent MHC-restricted T cell peptide epitope-induced late asthmatic reactions. J Exp Med 1999;189:1885–1894.
- 3, , , , Late asthmatic reactions induced by inhalation of allergen-derived T-cell peptides. Am J Respir Crit Care Med 2004;169:20–26.
- 4, , , , , et al. Late asthmatic reactions provoked by intradermal injection of T cell peptide epitopes are not associated with bronchial mucosal infiltration of eosinophils or Th2-type cells or elevated concentrations of histamine or eicosanoids in bronchoalveolar fluid. J Allergy Clin Immunol 2001;108:394–401.
- 5Neurogenic inflammation in the airways. Respir Physiol 2001;125:145–154.
- 6, , . Airway hyperresponsiveness and bronchial mucosal inflammation in T-cell peptide-induced asthmatic reactions in atopic subjects. Thorax 2007, in press.
- 7, , Allergen-derived T cell peptide-induced late asthmatic reactions precede the induction of antigen-specific hyporesponsiveness in atopic allergic asthmatic subjects. J Immunol 2001;167:1734–1739.
- 8, , , , , et al. Late asthmatic reactions provoked by intradermal injection of T-cell peptide epitopes are not associated with bronchial mucosal infiltration of eosinophils or T(H)2-type cells or with elevated concentrations of histamine or eicosanoids in bronchoalveolar fluid. J Allergy Clin Immunol 2001;108:394–401.
- 9, , , , , et al. Expression of IL-4 and IL-5 mRNA and protein product by CD4+ and CD8+ T cells, eosinophils, and mast cells in bronchial biopsies obtained from atopic and non atopic (intrinsic) asthmatics. J Immunol 1997;158:3539–3544.
- 10, , , , , Acute allergen-induced airway remodeling in atopic asthma. Am J Resp Cell Mol Biol 2004;31:S626–S632
- 11, , , , , et al. Anti-IL-5 treatment reduces deposition of ECM proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics. J Clin Invest 2003;112:1029–1036.
- 12, , , , , Neurokinin A is the predominant tachykinin in human bronchoalveolar lavage fluid in normal and asthmatic subjects. Thorax 1998;53:357–362.
- 13, , , Calcitonin gene-related peptide as inflammatory mediator. Pulm Pharm Ther 2003;16:121–130.
- 14, Vascular actions of calcitonin gene-related peptide and adrenomedullin. Physiol Rev 2004;84:903–934.
- 15, Inflammatory oedema induced by synergism between calcitonin gene-related peptide (CGRP) and mediators of increased vascular permeability. Br J Pharmac 1985;86:855–860.
- 16, , , , Calcitonin gene-related peptide is a potent vasodilator. Nature 1985;313:54–56.
- 17, , , , , et al. Attenuation of antigen-induced airway hyperresponsiveness in CGRP-deficient mice. Am J Physiol Lung Cell Mol Physiol 2002;283:L963-L970.
- 18, , , Interleukin-1-beta-calcitonin gene-related peptide secretion in human type II alveolar epithelial cells. FASEB J 2004;18:1603–1605.
- 19, , , , , The role of substance P in inflammatory disease. J Cell Physiol 2004;201:167–180.
- 20, , , , , et al. Calcitonin gene-related peptide is localised to human airway nerves and potently constricts human airway smooth muscle. Br J Pharmacol 1987;91:95–101.
- 21, , , , , et al. Effects of alpha calcitonin gene-related peptide in human bronchial smooth muscle and pulmonary artery. Regul Pept 2004;118:127–134.
- 22, , , , , Neuropeptide-containing nerves in endobronchial biopsies from asthmatic and nonasthmatic subjects. Am J Respir Cell Mol Biol 1995;13:288–296.
- 23, , , , , et al. Bronchial mucosal immunoreactivity of sensory neuropeptides in severe airway disease. Am J Respir Crit Care Med 1998;158:985–990.
- 24, , , , , Regulation of airway hyperresponsiveness by calcitonin gene-related peptide in allergen sensitized and challenged mice. Am J Respir Crit Care Med 2002;165:1137–1144.
- 25, , , , , et al. CD4+ invariant T-cell-receptor+ natural killer T cells in bronchial asthma. N Engl J Med 2006;354:1117–1129.
- 26, Multiple populations of T lymphocytes are distinguished by the level of CD4 and CD8 coexpression and require individual consideration. J Leuk Biol 2006;79:4–6
- 27, , , , , Production and secretion of calcitonin gene-related peptide from human lymphocytes. J Neuroimmunol 2002;130:155–162.
- 28, , Expression of vascular endothelial growth factor, basic fibroblast growth factor, and angiogenin immunoreactivity in asthmatic airways and its relationship to angiogenesis. J Allergy Clin Immunol 2001;107:295–301.
- 29, , , , Increased immunoreactivity of stromal cell-derived factor-1 and angiogenesis in asthma. Eur Respir J 2003;21:804–809.
- 30, , , , , et al. Increased airway vascularity in newly diagnosed asthma using a high-magnification bronchovideoscope. Am J Respir Crit Care Med 2003;168:1495–1499.

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