Get access

Nonspecific provocation of target organs in allergic diseases: EAACI-GA2LEN consensus report


Prof. Sergio Bonini
Professor of Internal Medicine
Second University of Naples
Institute of Neurobiology and Molecular Medicine
Italian National Research Council (INMM-CNR, ARTOV)
Via Fosso del Cavaliere 100
00133 Rome


It is widely accepted that nonspecific tissue reactivity is a distinct pathophysiological hallmark of allergic diseases, influenced by genetic and environmental factors different from those involved in causing sensitization and allergen response of target organs. This consensus document aims at reviewing procedures currently used for nonspecific provocation of the bronchi, nose and eye and for measuring their responsiveness to nonspecific stimuli.