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EAACI/GA2LEN guideline: aspirin provocation tests for diagnosis of aspirin hypersensitivity

  1. E. Niżankowska-Mogilnicka1,
  2. G. Bochenek1,
  3. L. Mastalerz1,
  4. M. Świerczyńska1,
  5. C. Picado2,
  6. G. Scadding3,
  7. M. L. Kowalski4,
  8. M. Setkowicz1,
  9. J. Ring5,
  10. K. Brockow5,
  11. C. Bachert6,
  12. S. Wöhrl7,
  13. B. Dahlén8,
  14. A. Szczeklik1

Article first published online: 22 MAY 2007

DOI: 10.1111/j.1398-9995.2007.01409.x

Issue

Allergy

Allergy

Volume 62, Issue 10, pages 1111–1118, October 2007

Additional Information

How to Cite

Niżankowska-Mogilnicka, E., Bochenek, G., Mastalerz, L., Świerczyńska, M., Picado, C., Scadding, G., Kowalski, M. L., Setkowicz, M., Ring, J., Brockow, K., Bachert, C., Wöhrl, S., Dahlén, B. and Szczeklik, A. (2007), EAACI/GA2LEN guideline: aspirin provocation tests for diagnosis of aspirin hypersensitivity. Allergy, 62: 1111–1118. doi: 10.1111/j.1398-9995.2007.01409.x

Author Information

  1. 1

    Department of Medicine, Jagiellonian University School of Medicine, Krakow, Poland

  2. 2

    Servei de Pneumologia i Allergia Respiratora, University of Barcelona, Barcelona, Spain

  3. 3

    Royal National Throat, Nose and Ear Hospital, London, UK

  4. 4

    Department of Clinical Immunology and Allergy, Medical University, Lodz, Poland

  5. 5

    Department of Dermatology and Allergy Biederstein, Technical University of Munich, Munich, Germany

  6. 6

    Department of Otorhinolaryngology, Ghent University, Belgium

  7. 7

    Department of Dermatology, Medical University of Vienna, Austria

  8. 8

    Centre for Allergy Research at Karolinska Institutet, Stockholm, Sweden

*Andrew Szczeklik, MD, PhD Department of Medicine Jagiellonian University School of Medicine 8 Skawinska Str. 31-066 Cracow Poland

Publication History

  1. Issue published online: 18 JUN 2007
  2. Article first published online: 22 MAY 2007
  3. Accepted for publication 5 April 2007

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Keywords:

  • aspirin;
  • aspirin challenge;
  • aspirin-induced asthma/rhinitis;
  • aspirin-induced urticaria;
  • hypersensitivity

Abstract:  Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most common causes of adverse drug reactions. Majority of them are of the hypersensitivity type. The two frequent clinical presentations of aspirin hypersensitivity are: aspirin-induced bronchial asthma/rhinosinusitis (AIA/R) and aspirin-induced urticaria/angioedema (AIU). The decisive diagnosis is based on provocation tests with aspirin, as the in vitro test does not hold diagnostic value as yet. Detailed protocols of oral, bronchial and nasal aspirin provocation tests are presented. Indications, contraindications for the tests, the rules of drug withdrawal and equipment are reviewed. Patient supervision and interpretations of the tests are proposed.

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