EAACI/GA2LEN guideline: aspirin provocation tests for diagnosis of aspirin hypersensitivity

Authors


Andrew Szczeklik, MD, PhD
Department of Medicine
Jagiellonian University School of Medicine
8 Skawinska Str.
31-066 Cracow
Poland

Abstract

Abstract:  Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most common causes of adverse drug reactions. Majority of them are of the hypersensitivity type. The two frequent clinical presentations of aspirin hypersensitivity are: aspirin-induced bronchial asthma/rhinosinusitis (AIA/R) and aspirin-induced urticaria/angioedema (AIU). The decisive diagnosis is based on provocation tests with aspirin, as the in vitro test does not hold diagnostic value as yet. Detailed protocols of oral, bronchial and nasal aspirin provocation tests are presented. Indications, contraindications for the tests, the rules of drug withdrawal and equipment are reviewed. Patient supervision and interpretations of the tests are proposed.

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