- Top of page
- Oral, single-blind, placebo-controlled diagnostic challenge (provocation) tests with aspirin
- Single-blind, placebo-controlled bronchial (inhalation) aspirin challenge
- Patient supervision after oral and/or inhalation challenge
- Single-blind, placebo-controlled nasal aspirin challenge (in patients suspected of suffering from AIA/R/nasal polyposis)
- Single-blind, placebo-controlled oral aspirin challenge test in patients suspected of aspirin-induced urticaria
- Protocol of oral aspirin challenge for the aspirin-induced urticaria patients
Abstract: Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most common causes of adverse drug reactions. Majority of them are of the hypersensitivity type. The two frequent clinical presentations of aspirin hypersensitivity are: aspirin-induced bronchial asthma/rhinosinusitis (AIA/R) and aspirin-induced urticaria/angioedema (AIU). The decisive diagnosis is based on provocation tests with aspirin, as the in vitro test does not hold diagnostic value as yet. Detailed protocols of oral, bronchial and nasal aspirin provocation tests are presented. Indications, contraindications for the tests, the rules of drug withdrawal and equipment are reviewed. Patient supervision and interpretations of the tests are proposed.