• 1
    Von Mutius E. The rising trends in asthma and allergic disease. Clin Exp Allergy 1998;28:4549.
  • 2
    Camargo CA Jr, Weiss ST, Zhang S, Willett WC, Speizer FE. Prospective study of body mass index, weight change, and risk of adult-onset asthma in women. Arch Intern Med 1999;159:25822588.
  • 3
    Figueroa-Munoz JI, Chinn S, Rona RJ. Association between obesity and asthma in 4-11 year old children in the UK. Thorax 2001;56:133137.
  • 4
    Castro-Rodriguez JA, Holberg CJ, Morgan WJ, Wright AL, Martinez FD. Increased incidence of asthmalike symptoms in girls who become overweight or obese during the school years. Am J Respir Crit Care Med 2001;163:13441349.
  • 5
    Chen Y, Dales R, Tang M, Krewski D. Obesity may increase the incidence of asthma in women but not in men: longitudinal observations from the Canadian National Population Health Surveys. Am J Epidemiol 2002;155:191197.
  • 6
    Huang SL, Shiao G, Chou P. Association between body mass index and allergy in teenage girls in Taiwan. Clin Exp Allergy 1999;29:323329.
  • 7
    Schachter LM, Salome CM, Peat JK, Woolcock AJ. Obesity is a risk for asthma and wheeze but not airway hyperresponsiveness. Thorax 2001;56:48.
  • 8
    Macgregor AM, Greenberg RA. Effect of surgically induced weight loss on asthma in the morbidly obese. Obes Surg 1993;3:1521.
  • 9
    Hakala K, Stenius-Aarniala B, Sovijarvi A. Effects of weight loss on peak flow variability, airways obstruction, and lung volumes in obese patients with asthma. Chest 2000;118:13151321.
  • 10
    Weiss ST. Obesity: insight into the origins of asthma. Nat Immunol 2005;6:537539.
  • 11
    Weiss ST, Shore S. Obesity and asthma: directions for research. Am J Respir Crit Care Med 2004;169:963968.
  • 12
    Palmer LJ, Cookson OCM. Atopy and asthma. In: BishopT, ShamP, editors. Analysis of multifactorial disease. BIOS: Oxford, 2000:215217.
  • 13
    Martin N, Boomsma D, Machin G. A twin-pronged attack on complex traits, Nat Genet 1997;17:387391.
  • 14
    Kyvik KO, Green A, Beck-Nielsen H. The new Danish Twin Register: establishment and analysis of twinning rates. Int J Epidemiol 1995;24:589596.
  • 15
    Christiansen L, Frederiksen H, Schousboe K, Skytthe A, Von Wurmb-Schwark N, Christensen K et al. Age- and sex-differences in the validity of questionnaire-based zygosity in twins. Twin Res 2003;6:275278.
  • 16
    Ferris BG. Epidemiology Standardization Project (American Thoracic Society). Am Rev Respir Dis 1978;118:1120.
  • 17
    Torén K, Brisman J, Järvholm B. Asthma and asthma-like symptoms in adults assessed by questionnaires. Chest 1993;104:600608.
  • 18
    Neale MC, Cardon LR. Methodology for genetic studies of twins and families. Dordrecht, the Netherlands: Kluwer Academic, 1992.
  • 19
    Posthuma D, Beem AL, De Geus EJ, Van Baal GC, Van Hjelmborg JB, Iachine I et al. Theory and practice in quantitative genetics. Twin Res 2003;6:361376.
  • 20
    Neale MC, Boker SM, Xie G, Maas HH. Mx statistical modeling, 5th ed.. Department of Psychiatry, Medical College of Virginia: Richmond Va, 1999.
  • 21
    Hallstrand TS, Fischer ME, Wurfel MM, Afari N, Buchwald D, Goldberg J. Genetic pleiotropy between asthma and obesity in a community-based sample of twins. J Allergy Clin Immunol 2005;116:12351241.
  • 22
    Tantisira KG, Weiss ST. Complex interactions in complex traits: obesity and asthma. Thorax 2001;56:ii64ii73.
  • 23
    Shin HD, Park BL, Kim LH, Jung JH, Wang HJ, Kim YJ et al. Association of tumor necrosis factor polymorphisms with asthma and serum total IgE. Hum Mol Genet 2004;13:397403.
  • 24
    Li Kam Wa TC, Mansur AH, Britton J, Williams G, Pavord I, Richards K et al. Association between - 308 tumour necrosis factor promoter polymorphism and bronchial hyperreactivity in asthma. Clin Exp Allergy 1999;29:12041208.
  • 25
    Rosmond R. Association studies of genetic polymorphisms in central obesity: a critical review. Int J Obes Relat Metab Disord 2003;27:11411151.
  • 26
    Palmer LJ. Linkages and associations to intermediate phenotypes underlying asthma and allergic disease. Curr Opin Allergy Clin Immunol 2001;1:393398.
  • 27
    Cassell PG, Saker PJ, Huxtable SJ, Kousta E, Jackson AE, Hattersley AT et al. Evidence that single nucleotide polymorphism in the uncoupling protein 3 (UCP3) gene influences fat distribution in women of European and Asian origin. Diabetologia 2000;43:15581564.
  • 28
    Lee YH, Pratley RE. The evolving role of inflammation in obesity and the metabolic syndrome. Curr Diab Rep 2005;5:7075.
  • 29
    De Winter-de Groot KM, Van der Ent CK, Prins I, Tersmette JM, Uiterwaal CS. Exhaled nitric oxide: the missing link between asthma and obesity? J Allergy Clin Immunol 2005;115:419420.
  • 30
    Cookson WO. Asthma genetics. Chest 2002;121:7S13S.
  • 31
    Shore SA, Fredberg JJ. Obesity, smooth muscle, and airway hyperresponsiveness. J Allergy Clin Immunol 2005;115:925927.
  • 32
    Gunnbjornsdottir MI, Omenaas E, Gislason T, Norrman E, Olin AC, Jögi R et al. Obesity and nocturnal gastro-oesophageal reflux are related to onset of asthma and respiratory symptoms. Eur Respir J 2004;24:116121.
  • 33
    Troisi RJ, Speizer FE, Willett WC et al. Menopause, postmenopausal estrogen preparations, and the risk of adult-onset asthma. A prospective cohort study. Am J Respir Crit Care Med 1995;152:11831188.
  • 34
    Varraso R, Siroux V, Maccario J et al. Asthma severity is associated with body mass index and early menarche in women. Am J Respir Crit Care Med 2005;171:334339.
  • 35
    Ford ES. The epidemiology of obesity and asthma. J Allergy Clin Immunol 2005;115:897909.