Once daily fluticasone furoate nasal spray is effective in seasonal allergic rhinitis caused by grass pollen
Article first published online: 4 AUG 2007
Volume 62, Issue 9, pages 1078–1084, September 2007
How to Cite
Fokkens, W. J., Jogi, R., Reinartz, S., Sidorenko, I., Sitkauskiene, B., Van Oene, C., Faris, M. A., Ellsworth, A. and Caldwell, M. F. (2007), Once daily fluticasone furoate nasal spray is effective in seasonal allergic rhinitis caused by grass pollen. Allergy, 62: 1078–1084. doi: 10.1111/j.1398-9995.2007.01522.x
- Issue published online: 4 AUG 2007
- Article first published online: 4 AUG 2007
- Accepted for publication 17 July 2007
- fluticasone furoate nasal spray;
- intranasal glucocorticoid;
- nasal symptoms;
- ocular symptoms;
- seasonal allergic rhinitis
Background: Fluticasone furoate is a new enhanced-affinity glucocorticoid with a unique combination of pharmacodynamic and physicochemical properties suitable for topical activity.
Methods: In this multicentre, randomized, double-blind, placebo-controlled, parallel-group study, patients [adults and adolescents ≥12 years of age with seasonal allergic rhinitis (SAR)] received once-daily (od) treatment for 2 weeks with either fluticasone furoate nasal spray 110 μg (n = 141) or placebo nasal spray (n = 144) administered in a unique, side-actuated device. Efficacy measures included total nasal symptom score (TNSS) and total ocular symptom score (TOSS). Patients also reported their overall response to therapy and rated their quality of life using the Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ).
Results: Fluticasone furoate significantly improved the mean change from baseline in daily reflective TNSS compared with placebo (treatment difference of −1.757; P < 0.001). Fluticasone furoate was also significantly more effective in improving the morning predose instantaneous TNSS (treatment difference of −1.898; P < 0.001) and daily reflective TOSS (treatment difference of −0.741; P = 0.001). A significant treatment effect was observed as early as day 1. Compared with placebo-treated patients, fluticasone furoate-treated patients showed significantly greater improvements in overall evaluation of response to therapy (P < 0.001), as well as in overall RQLQ score (P < 0.001). Fluticasone furoate was well tolerated.
Conclusion: Fluticasone furoate nasal spray 110 μg od was effective in improving the nasal symptoms of SAR. It also produced significant improvements in ocular symptoms.