• 1
    Becker A, Berube D, Chad Z, Dolovich M, Ducharme F, D’Urzo T et al. Canadian Pediatric Asthma Consensus guidelines, 2003 (updated to December 2004): introduction. CMAJ 2005;173:S12S14.
  • 2
    Busquets Monge RM, Sanchez SE, Pardos RL, Villa A Jr, Sanchez JJ, Ibero IM et al. [SENP-SEICAP (Spanish Society of Pediatric Pneunomology. Spanish Society of Pediatric Clinical Immunology and Allergology) consensus on asthma, pneumonology, and pediatric allergy (Draft)]. Allergol Immunopathol (Madr) 2004;32:104118.
  • 3
    Berdel D, Forster J, Gappa M, Kiosz D, Leupold W, Pfeiffer-Kascha D et al. Asthma bronchiale im Kindes - und Jugendalter. AWMF Leitlinien, AWMF-Leitlinien-Register Nr.026/010 2006.; accessed 7 November 2007.
  • 4
    Duiverman EJ, Brackel HJ, Merkus PJ, Rottier BL, Brand PL. [Guideline ‘Treating asthma in children’ for pediatric pulmonologists (2nd revised edition). II. Medical treatment]. Ned Tijdschr Geneeskd 2003;147:19091913.
  • 5
    Warner JO, Naspitz CK. Third International Pediatric Consensus statement on the management of childhood asthma. International Pediatric Asthma Consensus Group. Pediatr Pulmonol 1998;25:117.
  • 6
    Global Strategy for Asthma Management and Prevention 2006. The Global Initiative for Asthma 2006.; accessed 7 Novmber 2007.
  • 7
    National Asthma Education and Prevention Program. NAEPP expert panel report guidelines for the diagnosis and management of asthma – update on selected topics 2002. National Institutes for Health 2006:; accessed 7 November 2007.
  • 8
    Dahl R, Bjermer L. Nordic consensus report on asthma management. Nordic Asthma Consensus Group. Respir Med 2000;94:299327.
  • 9
    British guideline on the management of asthma. Thorax 2003;58 (Suppl. 1):i1i94.
  • 10
    Illi S, Von ME, Lau S, Niggemann B, Gruber C, Wahn U. Perennial allergen sensitisation early in life and chronic asthma in children: a birth cohort study. Lancet 2006;368:763770.
  • 11
    Morgan WJ, Stern DA, Sherrill DL, Guerra S, Holberg CJ, Guilbert TW et al. Outcome of asthma and wheezing in the first 6 years of life: follow-up through adolescence. Am J Respir Crit Care Med 2005;172:1253 1258.
  • 12
    Taussig LM, Wright AL, Holberg CJ, Halonen M, Morgan WJ, Martinez FD. Tucson Children’s Respiratory Study: 1980 to present. J Allergy Clin Immunol 2003;111:661675.
  • 13
    Bacharier LB, Phillips BR, Bloomberg GR, Zeiger RS, Paul IM, Krawiec M et al. Severe intermittent wheezing in preschool children: a distinct phenotype. J Allergy Clin Immunol 2007;119:604610.
  • 14
    Rhodes HL, Thomas P, Sporik R, Holgate ST, Cogswell JJ. A birth cohort study of subjects at risk of atopy: twenty-two-year follow-up of wheeze and atopic status. Am J Respir Crit Care Med 2002;165:176180.
  • 15
    Castro-Rodriguez JA, Holberg CJ, Wright AL, Martinez FD. A clinical index to define risk of asthma in young children with recurrent wheezing. Am J Respir Crit Care Med 2000;162:14031406.
  • 16
    De Marco R, Pattaro C, Locatelli F, Svanes C. Influence of early life exposures on incidence and remission of asthma throughout life. J Allergy Clin Immunol 2004;113:845852.
  • 17
    Phelan PD, Robertson CF, Olinsky A. The Melbourne Asthma Study: 1964–1999. J Allergy Clin Immunol 2002;109:189194.
  • 18
    Sears MR, Greene JM, Willan AR, Wiecek EM, Taylor DR, Flannery EM et al. A longitudinal, population-based, cohort study of childhood asthma followed to adulthood. N Engl J Med 2003;349:14141422.
  • 19
    Martinez FD, Wright AL, Taussig LM, Holberg CJ, Halonen M, Morgan WJ. Asthma and wheezing in the first six years of life. The Group Health Medical Associates. N Engl J Med 1995;332:133138.
  • 20
    Devulapalli CS, Carlsen KC, Haland G, Munthe-Kaas MC, Pettersen M, Mowinckel P et al. Severity of obstructive airways disease by two years predicts asthma at 10 years of age. Thorax 2007;DOI: 10.1136/thx.2006.060616.
  • 21
    Ober C, Hoffjan S. Asthma genetics 2006: the long and winding road to gene discovery. Genes Immun 2006;7:95100.
  • 22
    Eder W, Klimecki W, Yu L, Von ME, Riedler J, Braun-Fahrlander C et al. Opposite effects of CD 14/-260 on serum IgE levels in children raised in different environments. J Allergy Clin Immunol 2005;116:601607.
  • 23
    Braun-Fahrlander C, Riedler J, Herz U, Eder W, Waser M, Grize L et al. Environmental exposure to endotoxin and its relation to asthma in school-age children. N Engl J Med 2002;347:869877.
  • 24
    Guilbert TW, Morgan WJ, Zeiger RS, Bacharier LB, Boehmer SJ, Krawiec M et al. Atopic characteristics of children with recurrent wheezing at high risk for the development of childhood asthma. J Allergy Clin Immunol 2004;114:12821287.
  • 25
    Gissler M, Jarvelin MR, Louhiala P, Hemminki E. Boys have more health problems in childhood than girls: follow-up of the 1987 Finnish birth cohort. Acta Paediatr 1999;88:310314.
  • 26
    Anderson HR, Pottier AC, Strachan DP. Asthma from birth to age 23: incidence and relation to prior and concurrent atopic disease. Thorax 1992;47:537542.
  • 27
    Osman M, Tagiyeva N, Wassall HJ, Ninan TK, Devenny AM, McNeill G et al. Changing trends in sex specific prevalence rates for childhood asthma, eczema, and hay fever. Pediatr Pulmonol 2007;42:6065.
  • 28
    De Marco R, Locatelli F, Sunyer J, Burney P. Differences in incidence of reported asthma related to age in men and women. A retrospective analysis of the data of the European Respiratory Health Survey. Am J Respir Crit Care Med 2000;162:6874.
  • 29
    Lau S, Illi S, Sommerfeld C, Niggemann B, Bergmann R, Von ME et al. Early exposure to house-dust mite and cat allergens and development of childhood asthma: a cohort study. Multicentre Allergy Study Group. Lancet 2000;356:13921397.
  • 30
    Plaschke P, Janson C, Norrman E, Bjornsson E, Ellbjar S, Jarvholm B. Association between atopic sensitization and asthma and bronchial hyperresponsiveness in swedish adults: pets, and not mites, are the most important allergens. J Allergy Clin Immunol 1999;104:5865.
  • 31
    Perzanowski MS, Ronmark E, Platts-Mills TA, Lundback B. Effect of cat and dog ownership on sensitization and development of asthma among preteenage children. Am J Respir Crit Care Med 2002;166:696702.
  • 32
    Illi S, Von ME, Lau S, Nickel R, Gruber C, Niggemann B et al. The natural course of atopic dermatitis from birth to age 7 years and the association with asthma. J Allergy Clin Immunol 2004;113:925931.
  • 33
    Matricardi PM, Rosmini F, Panetta V, Ferrigno L, Bonini S. Hay fever and asthma in relation to markers of infection in the United States. J Allergy Clin Immunol 2002;110:381387.
  • 34
    Schaub B, Lauener R, Von ME. The many faces of the hygiene hypothesis. J Allergy Clin Immunol 2006;117:969977.
  • 35
    Ota MO, Van Der Sande MA, Walraven GE, Jeffries D, Nyan OA, Marchant A et al. Absence of association between delayed type hypersensitivity to tuberculin and atopy in children in The Gambia. Clin Exp Allergy 2003;33:731736.
  • 36
    Illi S, Von ME, Lau S, Bergmann R, Niggemann B, Sommerfeld C et al. Early childhood infectious diseases and the development of asthma up to school age: a birth cohort study. BMJ 2001;322:390395.
  • 37
    Ball TM, Castro-Rodriguez JA, Griffith KA, Holberg CJ, Martinez FD, Wright AL. Siblings, day-care attendance, and the risk of asthma and wheezing during childhood. N Engl J Med 2000;343:538543.
  • 38
    Sigurs N, Gustafsson PM, Bjarnason R, Lundberg F, Schmidt S, Sigurbergsson F et al. Severe respiratory syncytial virus bronchiolitis in infancy and asthma and allergy at age 13. Am J Respir Crit Care Med 2005;171:137141.
  • 39
    Lemanske RF Jr, Jackson DJ, Gangnon RE, Evans MD, Li Z, Shult PA et al. Rhinovirus illnesses during infancy predict subsequent childhood wheezing. J Allergy Clin Immunol 2005;116:571577.
  • 40
    Nafstad P, Brunekreef B, Skrondal A, Nystad W. Early respiratory infections, asthma, and allergy: 10-year follow-up of the Oslo Birth Cohort. Pediatrics 2005;116:e255e262.
  • 41
    Johnston SL, Pattemore PK, Sanderson G, Smith S, Lampe F, Josephs L et al. Community study of role of viral infections in exacerbations of asthma in 9-11 year old children. BMJ 1995;310:12251229.
  • 42
    Heymann PW, Carper HT, Murphy DD, Platts-Mills TA, Patrie J, McLaughlin AP et al. Viral infections in relation to age, atopy, and season of admission among children hospitalized for wheezing. J Allergy Clin Immunol 2004;114:239247.
  • 43
    Murray CS, Poletti G, Kebadze T, Morris J, Woodcock A, Johnston SL et al. Study of modifiable risk factors for asthma exacerbations: virus infection and allergen exposure increase the risk of asthma hospital admissions in children. Thorax 2006;61:376382.
  • 44
    Sigurs N. Clinical perspectives on the association between respiratory syncytial virus and reactive airway disease. Respir Res 2002;3 (Suppl. 1):S8S14.
  • 45
    Papadopoulos NG, Bates PJ, Bardin PG, Papi A, Leir SH, Fraenkel DJ et al. Rhinoviruses infect the lower airways. J Infect Dis 2000;181:18751884.
  • 46
    Papadopoulos NG, Stanciu LA, Papi A, Holgate ST, Johnston SL. A defective type 1 response to rhinovirus in atopic asthma. Thorax 2002;57:328332.
  • 47
    Xepapadaki P, Papadopoulos NG, Bossios A, Manoussakis E, Manousakas T, Saxoni-Papageorgiou P. Duration of postviral airway hyperresponsiveness in children with asthma: effect of atopy. J Allergy Clin Immunol 2005;116:299304.
  • 48
    Gruber C, Illi S, Lau S, Nickel R, Forster J, Kamin W et al. Transient suppression of atopy in early childhood is associated with high vaccination coverage. Pediatrics 2003;111:e282e288.
  • 49
    Floistrup H, Swartz J, Bergstrom A, Alm JS, Scheynius A, Van HM et al. Allergic disease and sensitization in Steiner school children. J Allergy Clin Immunol 2006;117:5966.
  • 50
    Johnson CC, Ownby DR, Alford SH, Havstad SL, Williams LK, Zoratti EM et al. Antibiotic exposure in early infancy and risk for childhood atopy. J Allergy Clin Immunol 2005;115:12181224.
  • 51
    Moshammer H, Hoek G, Luttmann-Gibson H, Neuberger MA, Antova T, Gehring U et al. Parental smoking and lung function in children: an international study. Am J Respir Crit Care Med 2006;173:12551263.
  • 52
    Burrows B, Bloom JW, Traver GA, Cline MG. The course and prognosis of different forms of chronic airways obstruction in a sample from the general population. N Engl J Med 1987;317:13091314.
  • 53
    Chalmers GW, Macleod KJ, Little SA, Thomson LJ, McSharry CP, Thomson NC. Influence of cigarette smoking on inhaled corticosteroid treatment in mild asthma. Thorax 2002;57:226230.
  • 54
    Halken S. Prevention of allergic disease in childhood: clinical and epidemiological aspects of primary and secondary allergy prevention. Pediatr Allergy Immunol 2004;15 (Suppl. 16):432.
  • 55
    Weiland SK, Von ME, Hirsch T, Duhme H, Fritzsch C, Werner B et al. Prevalence of respiratory and atopic disorders among children in the East and West of Germany five years after unification. Eur Respir J 1999;14:862870.
  • 56
    Hirsch T, Weiland SK, Von ME, Safeca AF, Grafe H, Csaplovics E et al. Inner city air pollution and respiratory health and atopy in children. Eur Respir J 1999;14:669677.
  • 57
    D’Amato G, Liccardi G, D’Amato M, Holgate S. Environmental risk factors and allergic bronchial asthma. Clin Exp Allergy 2005;35:11131124.
  • 58
    Gauderman WJ, Avol E, Lurmann F, Kuenzli N, Gilliland F, Peters J et al. Childhood asthma and exposure to traffic and nitrogen dioxide. Epidemiology 2005;16:737743.
  • 59
    Millstein J, Gilliland F, Berhane K, Gauderman WJ, McConnell R, Avol E et al. Effects of ambient air pollutants on asthma medication use and wheezing among fourth-grade school children from 12 Southern California communities enrolled in The Children’s Health Study. Arch Environ Health 2004;59:505514.
  • 60
    Van Odijk J, Kull I, Borres MP, Brandtzaeg P, Edberg U, Hanson LA et al. Breastfeeding and allergic disease: a multidisciplinary review of the literature (1966–2001) on the mode of early feeding in infancy and its impact on later atopic manifestations. Allergy 2003;58:833843.
  • 61
    Von Berg A, Koletzko S, Filipiak-Pittroff B, Laubereau B, Grubl A, Wichmann HE et al. Certain hydrolyzed formulas reduce the incidence of atopic dermatitis but not that of asthma: three-year results of the German Infant Nutritional Intervention Study. J Allergy Clin Immunol 2007;119:718725.
  • 62
    Von Berg A, Koletzko S, Grubl A, Filipiak-Pittroff B, Wichmann HE, Bauer CP et al. The effect of hydrolyzed cow’s milk formula for allergy prevention in the first year of life: the German Infant Nutritional Intervention Study, a randomized double-blind trial. J Allergy Clin Immunol 2003;111:533540.
  • 63
    Zeiger RS, Heller S, Mellon MH, Forsythe AB, O’Connor RD, Hamburger RN et al. Effect of combined maternal and infant food-allergen avoidance on development of atopy in early infancy: a randomized study. J Allergy Clin Immunol 1989;84:7289.
  • 64
    Devereux G, Seaton A. Diet as a risk factor for atopy and asthma. J Allergy Clin Immunol 2005;115:11091117.
  • 65
    Flaherman V, Rutherford GW. A meta-analysis of the effect of high weight on asthma. Arch Dis Child 2006;91:334339.
  • 66
    Mihrshahi S, Peat JK, Webb K, Oddy W, Marks GB, Mellis CM. Effect of omega-3 fatty acid concentrations in plasma on symptoms of asthma at 18 month of age. Pediatr Allergy Immunol 2004;15:517522.
  • 67
    Peat JK, Mihrshahi S, Kemp AS, Marks GB, Tovey ER, Webb K et al. Three-year outcomes of dietary fatty acid modification and house dust mite reduction in the Childhood Asthma Prevention Study. J Allergy Clin Immunol 2004;114:807813.
  • 68
    Bernard A, Carbonnelle S, Michel O, Higuet S, De BC, Buchet JP et al. Lung hyperpermeability and asthma prevalence in schoolchildren: unexpected associations with the attendance at indoor chlorinated swimming pools. Occup Environ Med 2003;60:385394.
  • 69
    Lee TH, Anderson SD. Heterogeneity of mechanisms in exercise induced asthma. Thorax 1985;40:481487.
  • 70
    Parsons JP, Mastronarde JG. Exercise-induced bronchoconstriction in athletes. Chest 2005;128:39663974.
  • 71
    Rasmussen F, Lambrechtsen J, Siersted HC, Hansen HS, Hansen NC. Low physical fitness in childhood is associated with the development of asthma in young adulthood: the Odense schoolchild study. Eur Respir J 2000;16:866870.
  • 72
    Villeneuve PJ, Leech J, Bourque D. Frequency of emergency room visits for childhood asthma in Ottawa, Canada: the role of weather. Int J Biometeorol 2005;50:4856.
  • 73
    Wright RJ, Rodriguez M, Cohen S. Review of psychosocial stress and asthma: an integrated biopsychosocial approach. Thorax 1998;53:10661074.
  • 74
    Wright RJ, Cohen S, Carey V, Weiss ST, Gold DR. Parental stress as a predictor of wheezing in infancy: a prospective birth-cohort study. Am J Respir Crit Care Med 2002;165:358365.
  • 75
    Xuan W, Marks GB, Toelle BG, Belousova E, Peat JK, Berry G et al. Risk factors for onset and remission of atopy, wheeze, and airway hyperresponsiveness. Thorax 2002;57:104109.
  • 76
    Wenzel S. Physiologic and pathologic abnormalities in severe asthma. Clin Chest Med 2006;27:2940.
  • 77
    De Blic J, Tillie-Leblond I, Tonnel AB, Jaubert F, Scheinmann P, Gosset P. Difficult asthma in children: an analysis of airway inflammation. J Allergy Clin Immunol 2004;113:94100.
  • 78
    Martinez FD. Maturation of immune responses at the beginning of asthma. J Allergy Clin Immunol 1999;103:355361.
  • 79
    Holt PG, Upham JW, Sly PD. Contemporaneous maturation of immunologic and respiratory functions during early childhood: implications for development of asthma prevention strategies. J Allergy Clin Immunol 2005;116:1624.
  • 80
    Chernick V, West J. The functional basis of respiratory disease. In: ChernickV, BoatT, WilmottR, BushA, editors. Kendig’s disorders of the respiratory tract in children. Philadelphia, PA: Saunders, 2006:2964.
  • 81
    Hoffjan S, Ostrovnaja I, Nicolae D, Newman DL, Nicolae R, Gangnon R et al. Genetic variation in immunoregulatory pathways and atopic phenotypes in infancy. J Allergy Clin Immunol 2004;113:511518.
  • 82
    Meyers DA, Postma DS, Stine OC, Koppelman GH, Ampleford EJ, Jongepier H et al. Genome screen for asthma and bronchial hyperresponsiveness: interactions with passive smoke exposure. J Allergy Clin Immunol 2005;115:11691175.
  • 83
    Stevenson EC, Turner G, Heaney LG, Schock BC, Taylor R, Gallagher T et al. Bronchoalveolar lavage findings suggest two different forms of childhood asthma. Clin Exp Allergy 1997;27:10271035.
  • 84
    Heaton T, Rowe J, Turner S, Aalberse RC, De KN, Suriyaarachchi D et al. An immunoepidemiological approach to asthma: identification of in-vitro T-cell response patterns associated with different wheezing phenotypes in children. Lancet 2005;365:142149.
  • 85
    Pohunek P, Warner JO, Turzikova J, Kudrmann J, Roche WR. Markers of eosinophilic inflammation and tissue re-modelling in children before clinically diagnosed bronchial asthma. Pediatr Allergy Immunol 2005;16:4351.
  • 86
    Marguet C, Jouen-Boedes F, Dean TP, Warner JO. Bronchoalveolar cell profiles in children with asthma, infantile wheeze, chronic cough, or cystic fibrosis. Am J Respir Crit Care Med 1999;159:15331540.
  • 87
    Denburg JA, Sehmi R, Saito H, Pil-Seob J, Inman MD, O’Byrne PM. Systemic aspects of allergic disease: bone marrow responses. J Allergy Clin Immunol 2000;106:S242S246.
  • 88
    Meiler F, Zimmermann M, Blaser K, Akdis CA, Akdis M. T-cell subsets in the pathogenesis of human asthma. Curr Allergy Asthma Rep 2006;6:9196.
  • 89
    Smart JM, Kemp AS. Increased Th1 and Th2 allergen-induced cytokine responses in children with atopic disease. Clin Exp Allergy 2002;32:796802.
  • 90
    Gern JE, Brooks GD, Meyer P, Chang A, Shen K, Evans MD et al. Bidirectional interactions between viral respiratory illnesses and cytokine responses in the first year of life. J Allergy Clin Immunol 2006;117:7278.
  • 91
    Dahl ME, Dabbagh K, Liggitt D, Kim S, Lewis DB. Viral-induced T helper type 1 responses enhance allergic disease by effects on lung dendritic cells. Nat Immunol 2004;5:337343.
  • 92
    Akbari O, DeKruyff RH, Umetsu DT. Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen. Nat Immunol 2001;2:725731.
  • 93
    Lewkowich IP, Herman NS, Schleifer KW, Dance MP, Chen BL, Dienger KM et al. CD4+ CD25+ T cells protect against experimentally induced asthma and alter pulmonary dendritic cell phenotype and function. J Exp Med 2005;202:15491561.
  • 94
    Johansson SG, Bieber T, Dahl R, Friedmann PS, Lanier BQ, Lockey RF et al. Revised nomenclature for allergy for global use: report of the Nomenclature Review Committee of the World Allergy Organization, October 2003. J Allergy Clin Immunol 2004;113:832836.
  • 95
    Burrows B, Martinez FD, Halonen M, Barbee RA, Cline MG. Association of asthma with serum IgE levels and skin-test reactivity to allergens. N Engl J Med 1989;320:271277.
  • 96
    Wark PA, Johnston SL, Bucchieri F, Powell R, Puddicombe S, Laza-Stanca V et al. Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus. J Exp Med 2005;201:937947.
  • 97
    Van Den Toorn LM, Overbeek SE, De Jongste JC, Leman K, Hoogsteden HC, Prins JB. Airway inflammation is present during clinical remission of atopic asthma. Am J Respir Crit Care Med 2001;164:21072113.
  • 98
    Bousquet J, Jeffery PK, Busse WW, Johnson M, Vignola AM. Asthma. From bronchoconstriction to airways inflammation and remodeling. Am J Respir Crit Care Med 2000;161:17201745.
  • 99
    Barbato A, Turato G, Baraldo S, Bazzan E, Calabrese F, Tura M et al. Airway inflammation in childhood asthma. Am J Respir Crit Care Med 2003;168:798803.
  • 100
    Payne DN, Rogers AV, Adelroth E, Bandi V, Guntupalli KK, Bush A et al. Early thickening of the reticular basement membrane in children with difficult asthma. Am J Respir Crit Care Med 2003;167:7882.
  • 101
    Saglani S, Malmstrom K, Pelkonen AS, Malmberg LP, Lindahl H, Kajosaari M et al. Airway remodeling and inflammation in symptomatic infants with reversible airflow obstruction. Am J Respir Crit Care Med 2005;171:722727.
  • 102
    Davies DE, Wicks J, Powell RM, Puddicombe SM, Holgate ST. Airway remodeling in asthma: new insights. J Allergy Clin Immunol 2003;111:215225.
  • 103
    Vignola AM, Gagliardo R, Siena A, Chiappara G, Bonsignore MR, Bousquet J et al. Airway remodeling in the pathogenesis of asthma. Curr Allergy Asthma Rep 2001;1:108115.
  • 104
    Guilbert TW, Morgan WJ, Zeiger RS, Mauger DT, Boehmer SJ, Szefler SJ et al. Long-term inhaled corticosteroids in preschool children at high risk for asthma. N Engl J Med 2006;354:19851997.
  • 105
    Gaga M, Lambrou P, Papageorgiou N, Koulouris NG, Kosmas E, Fragakis S et al. Eosinophils are a feature of upper and lower airway pathology in non-atopic asthma, irrespective of the presence of rhinitis. Clin Exp Allergy 2000;30:663669.
  • 106
    Braunstahl GJ, KleinJan A, Overbeek SE, Prins JB, Hoogsteden HC, Fokkens WJ. Segmental bronchial provocation induces nasal inflammation in allergic rhinitis patients. Am J Respir Crit Care Med 2000;161:20512057.
  • 107
    Braunstahl GJ, Overbeek SE, KleinJan A, Prins JB, Hoogsteden HC, Fokkens WJ. Nasal allergen provocation induces adhesion molecule expression and tissue eosinophilia in upper and lower airways. J Allergy Clin Immunol 2001;107:469476.
  • 108
    Holgate ST, Holloway J, Wilson S, Bucchieri F, Puddicombe S, Davies DE. Epithelial-mesenchymal communication in the pathogenesis of chronic asthma. Proc Am Thorac Soc 2004;1:9398.
  • 109
    Cokugras H, Akcakaya N, Seckin, Camcioglu Y, Sarimurat N, Aksoy F. Ultrastructural examination of bronchial biopsy specimens from children with moderate asthma. Thorax 2001;56:2529.
  • 110
    Baraldi E, Dario C, Ongaro R, Scollo M, Azzolin NM, Panza N et al. Exhaled nitric oxide concentrations during treatment of wheezing exacerbation in infants and young children. Am J Respir Crit Care Med 1999;159:12841288.
  • 111
    Montgomery GL, Tepper RS. Changes in airway reactivity with age in normal infants and young children. Am Rev Respir Dis 1990;142:13721376.
  • 112
    Joos GF. The role of neuroeffector mechanisms in the pathogenesis of asthma. Curr Allergy Asthma Rep 2001;1:134143.
  • 113
    Gold MS, Kemp AS. Atopic disease in childhood. Med J Aust 2005;182:298304.
  • 114
    Hall CB, Wakefield D, Rowe TM, Carlisle PS, Cloutier MM. Diagnosing pediatric asthma: validating the Easy Breathing Survey. J Pediatr 2001;139:267272.
  • 115
    Elphick HE, Sherlock P, Foxall G, Simpson EJ, Shiell NA, Primhak RA et al. Survey of respiratory sounds in infants. Arch Dis Child 2001;84:3539.
  • 116
    Nickel R, Kulig M, Forster J, Bergmann R, Bauer CP, Lau S et al. Sensitization to hen’s egg at the age of twelve months is predictive for allergic sensitization to common indoor and outdoor allergens at the age of three years. J Allergy Clin Immunol 1997;99:613617.
  • 117
    Host A, Andrae S, Charkin S, Az-Vazquez C, Dreborg S, Eigenmann PA et al. Allergy testing in children: why, who, when and how? Allergy 2003;58:559569.
  • 118
    Wood RA. Skin testing: making the most of every prick. Ann Allergy Asthma Immunol 2002;88:347349.
  • 119
    Van Asperen PP, Kemp AS, Mellis CM. Skin test reactivity and clinical allergen sensitivity in infancy. J Allergy Clin Immunol 1984;73:381386.
  • 120
    Menardo JL, Bousquet J, Rodiere M, Astruc J, Michel FB. Skin test reactivity in infancy. J Allergy Clin Immunol 1985;75:646651.
  • 121
    Niemeijer NR, De Monchy JG. Age-dependency of sensitization to aero-allergens in asthmatics. Allergy 1992;47:431435.
  • 122
    Fiocchi A, Besana R, Ryden AC, Terracciano L, Andreotti M, Arrigoni S et al. Differential diagnosis of IgE-mediated allergy in young children with wheezing or eczema symptoms using a single blood test. Ann Allergy Asthma Immunol 2004;93:328333.
  • 123
    Nordvall SL, Janson C, Kalm-Stephens P, Foucard T, Toren K, Alving K. Exhaled nitric oxide in a population-based study of asthma and allergy in schoolchildren. Allergy 2005;60:469475.
  • 124
    Spahn JD, Chipps BE. Office-based objective measures in childhood asthma. J Pediatr 2006;148:1115.
  • 125
    Nair SJ, Daigle KL, DeCuir P, Lapin CD, Schramm CM. The influence of pulmonary function testing on the management of asthma in children. J Pediatr 2005;147:797801.
  • 126
    Zapletal A, Chalupova J. Forced expiratory parameters in healthy preschool children (3-6 years of age). Pediatr Pulmonol 2003;35:200207.
  • 127
    Miller MR, Crapo R, Hankinson J, Brusasco V, Burgos F, Casaburi R et al. General considerations for lung function testing. Eur Respir J 2005;26:153161.
  • 128
    Covar RA, Szefler SJ, Martin RJ, Sundstrom DA, Silkoff PE, Murphy J et al. Relations between exhaled nitric oxide and measures of disease activity among children with mild-to-moderate asthma. J Pediatr 2003;142:469475.
  • 129
    Covar RA, Spahn JD, Martin RJ, Silkoff PE, Sundstrom DA, Murphy J et al. Safety and application of induced sputum analysis in childhood asthma. J Allergy Clin Immunol 2004;114:575582.
  • 130
    Childhood Asthma Management Program Research Group. Long-term effects of budesonide or nedocromil in children with asthma. N Engl J Med 2000;343:10541063.
  • 131
    Paull K, Covar R, Jain N, Gelfand EW, Spahn JD. Do NHLBI lung function criteria apply to children?. A cross-sectional evaluation of childhood asthma at National Jewish Medical and Research Center, 1999–2002 Pediatr Pulmonol 2005;39:311317.
  • 132
    Bacharier LB, Strunk RC, Mauger D, White D, Lemanske RF Jr, Sorkness CA. Classifying asthma severity in children: mismatch between symptoms, medication use, and lung function. Am J Respir Crit Care Med 2004;170:426432.
  • 133
    Saglani S, Nicholson AG, Scallan M, Balfour-Lynn I, Rosenthal M, Payne DN et al. Investigation of young children with severe recurrent wheeze: any clinical benefit? Eur Respir J 2006;27:2935.
  • 134
    Gore C, Custovic A. Primary and secondary prevention of allergic airway disease. Paediatr Respir Rev 2003;4:213224.
  • 135
    Arshad SH, Bateman B, Matthews SM. Primary prevention of asthma and atopy during childhood by allergen avoidance in infancy: a randomised controlled study. Thorax 2003;58:489493.
  • 136
    Koopman LP, Van Strien RT, Kerkhof M, Wijga A, Smit HA, De Jongste JC et al. Placebo-controlled trial of house dust mite-impermeable mattress covers: effect on symptoms in early childhood. Am J Respir Crit Care Med 2002;166:307313.
  • 137
    Chan-Yeung M, Ferguson A, Watson W, Mich-Ward H, Rousseau R, Lilley M et al. The Canadian Childhood Asthma Primary Prevention Study: outcomes at 7 years of age. J Allergy Clin Immunol 2005;116:4955.
  • 138
    Custovic A, Simpson BM, Simpson A, Kissen P, Woodcock A. Effect of environmental manipulation in pregnancy and early life on respiratory symptoms and atopy during first year of life: a randomised trial. Lancet 2001;358:188193.
  • 139
    Woodcock A, Lowe LA, Murray CS, Simpson BM, Pipis SD, Kissen P et al. Early life environmental control: effect on symptoms, sensitization, and lung function at age 3 years. Am J Respir Crit Care Med 2004;170:433439.
  • 140
    Morgan WJ, Crain EF, Gruchalla RS, O’Connor GT, Kattan M, Evans R III et al. Results of a home-based environmental intervention among urban children with asthma. N Engl J Med 2004;351:10681080.
  • 141
    Nishioka K, Yasueda H, Saito H. Preventive effect of bedding encasement with microfine fibers on mite sensitization. J Allergy Clin Immunol 1998;101:2832.
  • 142
    O’Connor GT. Allergen avoidance in asthma: what do we do now? J Allergy Clin Immunol 2005;116:2630.
  • 143
    Eggleston PA. Improving indoor environments: reducing allergen exposures. J Allergy Clin Immunol 2005;116:122126.
  • 144
    Bock SA, Munoz-Furlong A, Sampson HA. Fatalities due to anaphylactic reactions to foods. J Allergy Clin Immunol 2001;107:191193.
  • 145
    El AW. Passive smoking and chronic illness in children: age and gender inequalities, and the fallacy of ‘low-strength’ cigarettes. Chronic Illn 2005;1:8791.
  • 146
    Skoner DP, Greos LS, Kim KT, Roach JM, Parsey M, Baumgartner RA. Evaluation of the safety and efficacy of levalbuterol in 2-5-year-old patients with asthma. Pediatr Pulmonol 2005;40:477486.
  • 147
    Rodrigo GJ, Castro-Rodriguez JA. Anticholinergics in the treatment of children and adults with acute asthma: a systematic review with meta-analysis. Thorax 2005;60:740746.
  • 148
    Everard ML, Bara A, Kurian M, Elliott TM, Ducharme F, Mayowe V. Anticholinergic drugs for wheeze in children under the age of two years. Cochrane Database Syst Rev 2005;CD001279.
  • 149
    Szefler SJ, Phillips BR, Martinez FD, Chinchilli VM, Lemanske RF, Strunk RC et al. Characterization of within-subject responses to fluticasone and montelukast in childhood asthma. J Allergy Clin Immunol 2005;115:233242.
  • 150
    Simons FE. A comparison of beclomethasone, salmeterol, and placebo in children with asthma. Canadian Beclomethasone Dipropionate-Salmeterol Xinafoate Study Group. N Engl J Med 1997;337:16591665.
  • 151
    Bisgaard H, Hermansen MN, Loland L, Halkjaer LB, Buchvald F. Intermittent inhaled corticosteroids in infants with episodic wheezing. N Engl J Med 2006;354:19982005.
  • 152
    Murray CS, Woodcock A, Langley SJ, Morris J, Custovic A. Secondary prevention of asthma by the use of Inhaled Fluticasone propionate in Wheezy INfants (IFWIN): double-blind, randomised, controlled study. Lancet 2006;368:754762.
  • 153
    Knorr B, Franchi LM, Bisgaard H, Vermeulen JH, LeSouef P, Santanello N et al. Montelukast, a leukotriene receptor antagonist, for the treatment of persistent asthma in children aged 2 to 5 years. Pediatrics 2001;108:E48.
  • 154
    Bisgaard H, Nielsen KG. Bronchoprotection with a leukotriene receptor antagonist in asthmatic preschool children. Am J Respir Crit Care Med 2000;162:187190.
  • 155
    Straub DA, Minocchieri S, Moeller A, Hamacher J, Wildhaber JH. The effect of montelukast on exhaled nitric oxide and lung function in asthmatic children 2 to 5 years old. Chest 2005;127:509514.
  • 156
    Straub DA, Moeller A, Minocchieri S, Hamacher J, Sennhauser FH, Hall GL et al. The effect of montelukast on lung function and exhaled nitric oxide in infants with early childhood asthma. Eur Respir J 2005;25:289294.
  • 157
    Simons FE, Villa JR, Lee BW, Teper AM, Lyttle B, Aristizabal G et al. Montelukast added to budesonide in children with persistent asthma: a randomized, double-blind, crossover study. J Pediatr 2001;138:694698.
  • 158
    Bisgaard H, Zielen S, Garcia-Garcia ML, Johnston SL, Gilles L, Menten J et al. Montelukast reduces asthma exacerbations in 2- to 5-year-old children with intermittent asthma. Am J Respir Crit Care Med 2005;171:315322.
  • 159
    Bisgaard H. A randomized trial of montelukast in respiratory syncytial virus postbronchiolitis. Am J Respir Crit Care Med 2003;167:379383.
  • 160
    Van Adelsberg J, Moy J, Wei LX, Tozzi CA, Knorr B, Reiss TF. Safety, tolerability, and exploratory efficacy of montelukast in 6- to 24-month-old patients with asthma. Curr Med Res Opin 2005;21:971979.
  • 161
    Verberne AA, Frost C, Duiverman EJ, Grol MH, Kerrebijn KF. Addition of salmeterol versus doubling the dose of beclomethasone in children with asthma. The Dutch Asthma Study Group. Am J Respir Crit Care Med 1998;158:213219.
  • 162
    Sorkness CA, Lemanske RF Jr, Mauger DT, Boehmer SJ, Chinchilli VM, Martinez FD et al. Long-term comparison of 3 controller regimens for mild-moderate persistent childhood asthma: the Pediatric Asthma Controller Trial. J Allergy Clin Immunol 2007;119:6472.
  • 163
    Salpeter SR, Buckley NS, Ormiston TM, Salpeter EE. Meta-analysis: effect of long-acting beta-agonists on severe asthma exacerbations and asthma-related deaths. Ann Intern Med 2006;144:904912.
  • 164
    Guevara JP, Ducharme FM, Keren R, Nihtianova S, Zorc J. Inhaled corticosteroids versus sodium cromoglycate in children and adults with asthma. Cochrane Database Syst Rev 2006;CD003558.
  • 165
    Walker S, Monteil M, Phelan K, Lasserson TJ, Walters EH. Anti-IgE for chronic asthma in adults and children. Cochrane Database Syst Rev 2006;CD003559.
  • 166
    Walters EH, Walters J. Inhaled short acting beta2-agonist use in chronic asthma: regular versus as needed treatment. Cochrane Database Syst Rev 2003;CD001285.
  • 167
    Sheffer AL, Silverman M, Woolcock AJ, Diaz PV, Lindberg B, Lindmark B. Long-term safety of once-daily budesonide in patients with early-onset mild persistent asthma: results of the Inhaled Steroid Treatment as Regular Therapy in Early Asthma (START) study. Ann Allergy Asthma Immunol 2005;94:4854.
  • 168
    Jonasson G, Carlsen KH, Mowinckel P. Asthma drug adherence in a long term clinical trial. Arch Dis Child 2000;83:330333.
  • 169
    Wolthers OD, Allen DB. Inhaled corticosteroids, growth, and compliance. N Engl J Med 2002;347:12101211.
  • 170
    Randell TL, Donaghue KC, Ambler GR, Cowell CT, Fitzgerald DA, Van Asperen PP. Safety of the newer inhaled corticosteroids in childhood asthma. Paediatr Drugs 2003;5:481504.
  • 171
    Sizonenko PC. Effects of inhaled or nasal glucocorticosteroids on adrenal function and growth. J Pediatr Endocrinol Metab 2002;15:526.
  • 172
    Pauwels RA, Pedersen S, Busse WW, Tan WC, Chen YZ, Ohlsson SV et al. Early intervention with budesonide in mild persistent asthma: a randomised, double-blind trial. Lancet 2003;361:10711076.
  • 173
    Sharek PJ, Bergman DA. Beclomethasone for asthma in children: effects on linear growth. Cochrane Database Syst Rev 2000;CD001282.
  • 174
    Sharek PJ, Bergman DA. The effect of inhaled steroids on the linear growth of children with asthma: a meta-analysis. Pediatrics 2000;106:E8.
  • 175
    Wolthers OD, Pedersen S. Growth of asthmatic children during treatment with budesonide: a double blind trial. BMJ 1991;303:163165.
  • 176
    Wolthers OD, Pedersen S. Controlled study of linear growth in asthmatic children during treatment with inhaled glucocorticosteroids. Pediatrics 1992;89:839842.
  • 177
    Wolthers OD, Heuck C. Assessment of the relation between short and intermediate term growth in children with asthma treated with inhaled glucocorticoids. Allergy 2004;59:11931197.
  • 178
    Wolthers OD, Pedersen S. Short-term growth during treatment with inhaled fluticasone propionate and beclomethasone dipropionate. Arch Dis Child 1993;68:673676.
  • 179
    Heuck C, Wolthers OD, Hansen M, Kollerup G. Short-term growth and collagen turnover in asthmatic adolescents treated with the inhaled glucocorticoid budesonide. Steroids 1997;62:659664.
  • 180
    Heuck C, Heickendorff L, Wolthers OD. A randomised controlled trial of short term growth and collagen turnover in asthmatics treated with inhaled formoterol and budesonide. Arch Dis Child 2000;83:334339.
  • 181
    Schou AJ, Heuck C, Wolthers OD. Does vitamin D administered to children with asthma treated with inhaled glucocorticoids affect short-term growth or bone turnover? Pediatr Pulmonol 2003;36:399404.
  • 182
    Schou AJ, Plomgaard AM, Thomsen K, Wolthers OD. Lower leg growth suppression caused by inhaled glucocorticoids is not accompanied by reduced thickness of the cutis or subcutis. Acta Paediatr 2004;93:623627.
  • 183
    Wolthers OD. Short-term growth and adrenal function in children with asthma treated with inhaled beclomethasone dipropionate hydrofluoroalkane-134a. Pediatr Allergy Immunol 2006;17:613619.
  • 184
    Heuck C, Wolthers OD, Kollerup G, Hansen M, Teisner B. Adverse effects of inhaled budesonide (800 micrograms) on growth and collagen turnover in children with asthma: a double-blind comparison of once-daily versus twice-daily administration. J Pediatr 1998;133:608612.
  • 185
    Chang KC, Miklich DR, Barwise G, Chai H, Miles-Lawrence R. Linear growth of chronic asthmatic children: the effects of the disease and various forms of steroid therapy. Clin Allergy 1982;12:369378.
  • 186
    Baum WF, Schneyer U, Lantzsch AM, Kloditz E. Delay of growth and development in children with bronchial asthma, atopic dermatitis and allergic rhinitis. Exp Clin Endocrinol Diabetes 2002;110:5359.
  • 187
    Norjavaara E, Gerhardsson DV, Lindmark B. Reduced height in swedish men with asthma at the age of conscription for military service. J Pediatr 2000;137:2529.
  • 188
    Shohat M, Shohat T, Kedem R, Mimouni M, Danon YL. Childhood asthma and growth outcome. Arch Dis Child 1987;62:6365.
  • 189
    Sim D, Griffiths A, Armstrong D, Clarke C, Rodda C, Freezer N. Adrenal suppression from high-dose inhaled fluticasone propionate in children with asthma. Eur Respir J 2003;21:633636.
  • 190
    Todd GR, Acerini CL, Ross-Russell R, Zahra S, Warner JT, McCance D. Survey of adrenal crisis associated with inhaled corticosteroids in the United Kingdom. Arch Dis Child 2002;87:457461.
  • 191
    Gulliver T, Eid N. Effects of glucocorticoids on the hypothalamic-pituitary-adrenal axis in children and adults. Immunol Allergy Clin North Am 2005;25:541555.
  • 192
    Lipworth BJ. Systemic adverse effects of inhaled corticosteroid therapy: A systematic review and meta-analysis. Arch Intern Med 1999;159:941955.
  • 193
    Dunlop KA, Carson DJ, Steen HJ, McGovern V, McNaboe J, Shields MD. Monitoring growth in asthmatic children treated with high dose inhaled glucocorticoids does not predict adrenal suppression. Arch Dis Child 2004;89:713716.
  • 194
    Priftis KN, Papadimitriou A, Gatsopoulou E, Yiallouros PK, Fretzayas A, Nicolaidou P. The effect of inhaled budesonide on adrenal and growth suppression in asthmatic children. Eur Respir J 2006;27:316320.
  • 195
    Allen DB. Inhaled steroids for children: effects on growth, bone, and adrenal function. Endocrinol Metab Clin North Am 2005;34:555564.
  • 196
    Roux C, Kolta S, Desfougeres JL, Minini P, Bidat E. Long-term safety of fluticasone propionate and nedocromil sodium on bone in children with asthma. Pediatrics 2003;111:e706e713.
  • 197
    Martinez FD. Safety of long-acting beta-agonists – an urgent need to clear the air. N Engl J Med 2005;353:26372639.
  • 198
    Nelson HS, Weiss ST, Bleecker ER, Yancey SW, Dorinsky PM. The Salmeterol Multicenter Asthma Research Trial: a comparison of usual pharmacotherapy for asthma or usual pharmacotherapy plus salmeterol. Chest 2006;129:1526.
  • 199
    Bisgaard H, Szefler S. Long-acting beta2 agonists and paediatric asthma. Lancet 2006;367:286288.
  • 200
    Ellis EF. Theophylline toxicity. J Allergy Clin Immunol 1985;76:297301.
  • 201
    Greenstone IR, Ni Chroinin MN, Masse V, Danish A, Magdalinos H, Zhang X et al. Combination of inhaled long-acting beta2-agonists and inhaled steroids versus higher dose of inhaled steroids in children and adults with persistent asthma. Cochrane Database Syst Rev 2005;CD005533.
  • 202
    Rabinovitch N, Zhang L, Gelfand EW. Urine leukotriene E4 levels are associated with decreased pulmonary function in children with persistent airway obstruction. J Allergy Clin Immunol 2006;118:635640.
  • 203
    Chavasse R, Seddon P, Bara A, McKean M. Short acting beta agonists for recurrent wheeze in children under 2 years of age. Cochrane Database Syst Rev 2002;CD002873.
  • 204
    Hofhuis W, Van Der Wiel EC, Tiddens HA, Brinkhorst G, Holland WP, De Jongste JC et al. Bronchodilation in infants with malacia or recurrent wheeze. Arch Dis Child 2003;88:246249.
  • 205
    Conner WT, Dolovich MB, Frame RA, Newhouse MT. Reliable salbutamol administration in 6- to 36-month-old children by means of a metered dose inhaler and Aerochamber with mask. Pediatr Pulmonol 1989;6:263267.
  • 206
    Kraemer R, Frey U, Sommer CW, Russi E. Short-term effect of albuterol, delivered via a new auxiliary device, in wheezy infants. Am Rev Respir Dis 1991;144:347351.
  • 207
    Zielen S, Rose MA, Bez C, Jarisch A, Reichenbach J, Hofmann D. Effectiveness of budesonide nebulising suspension compared to disodium cromoglycate in early childhood asthma. Curr Med Res Opin 2006;22:367373.
  • 208
    De Blic J, Delacourt C, Le BM, Mahut B, Ostinelli J, Caswell C et al. Efficacy of nebulized budesonide in treatment of severe infantile asthma: a double-blind study. J Allergy Clin Immunol 1996;98:1420.
  • 209
    Ilangovan P, Pedersen S, Godfrey S, Nikander K, Noviski N, Warner JO. Treatment of severe steroid dependent preschool asthma with nebulised budesonide suspension. Arch Dis Child 1993;68:356359.
  • 210
    Calpin C, Macarthur C, Stephens D, Feldman W, Parkin PC. Effectiveness of prophylactic inhaled steroids in childhood asthma: a systemic review of the literature. J Allergy Clin Immunol 1997;100:452457.
  • 211
    Schuh S, Dick PT, Stephens D, Hartley M, Khaikin S, Rodrigues L et al. High-dose inhaled fluticasone does not replace oral prednisolone in children with mild to moderate acute asthma. Pediatrics 2006;118:644650.
  • 212
    Boner AL, Spezia E, Piovesan P, Chiocca E, Maiocchi G. Inhaled formoterol in the prevention of exercise-induced bronchoconstriction in asthmatic children. Am J Respir Crit Care Med 1994;149:935939.
  • 213
    Carlsen KH, Roksund O, Olsholt K, Nja F, Leegaard J, Bratten G. Overnight protection by inhaled salmeterol on exercise-induced asthma in children. Eur Respir J 1995;8:18521855.
  • 214
    Henriksen JM, Dahl R. Effects of inhaled budesonide alone and in combination with low-dose terbutaline in children with exercise-induced asthma. Am Rev Respir Dis 1983;128:993997.
  • 215
    Pearlman DS, Van AJ, Philip G, Tilles SA, Busse W, Hendeles L et al. Onset and duration of protection against exercise-induced bronchoconstriction by a single oral dose of montelukast. Ann Allergy Asthma Immunol 2006;97:98104.
  • 216
    De Benedictis FM, Del Giudice MM, Forenza N, Decimo F, De BD, Capristo A. Lack of tolerance to the protective effect of montelukast in exercise-induced bronchoconstriction in children. Eur Respir J 2006;28:291295.
  • 217
    Simons FE, Gerstner TV, Cheang MS. Tolerance to the bronchoprotective effect of salmeterol in adolescents with exercise-induced asthma using concurrent inhaled glucocorticoid treatment 4. Pediatrics 1997;99:655659.
  • 218
    Balfour-Lynn I. Difficult asthma: beyond the guidelines. Arch Dis Child 1999;80:201206.
  • 219
    Payne DN, Balfour-Lynn IM. Children with difficult asthma: a practical approach. J Asthma 2001;38:189203.
  • 220
    Payne D, Bush A. Phenotype-specific treatment of difficult asthma in children. Paediatr Respir Rev 2004;5:116123.
  • 221
    Ahrens RC. The role of the MDI and DPI in pediatric patients: ‘Children are not just miniature adults’. Respir Care 2005;50:13231328.
  • 222
    Cates CJ, Bestall J, Adams N. Holding chambers versus nebulisers for inhaled steroids in chronic asthma. Cochrane Database Syst Rev 2006;CD001491.
  • 223
    Boyd R, Stuart P. Pressurised metered dose inhalers with spacers versus nebulisers for beta-agonist delivery in acute asthma in children in the emergency department. Emerg Med J 2005;22:641642.
  • 224
    Rubilar L, Castro-Rodriguez JA, Girardi G. Randomized trial of salbutamol via metered-dose inhaler with spacer versus nebulizer for acute wheezing in children less than 2 years of age. Pediatr Pulmonol 2000;29:264269.
  • 225
    De Benedictis FM, Selvaggio D. Use of inhaler devices in pediatric asthma. Paediatr Drugs 2003;5:629638.
  • 226
    Milgrom H, Berger W, Nayak A, Gupta N, Pollard S, McAlary M et al. Treatment of childhood asthma with anti-immunoglobulin E antibody (omalizumab). Pediatrics 2001;108:E36.
  • 227
    Richeldi L, Ferrara G, Fabbri LM, Lasserson TJ, Gibson PG. Macrolides for chronic asthma. Cochrane Database Syst Rev 2005;CD002997.
  • 228
    Pajno GB. Allergen immunotherapy in early childhood: between Scylla and Charybdis!. Clin Exp Allergy 2005;35:551553.
  • 229
    Abramson MJ, Puy RM, Weiner JM. Allergen immunotherapy for asthma. Cochrane Database Syst Rev 2003;CD001186.
  • 230
    Des Roches A, Paradis L, Menardo JL, Bouges S, Daures JP, Bousquet J. Immunotherapy with a standardized Dermatophagoides pteronyssinus extract. VI. Specific immunotherapy prevents the onset of new sensitizations in children. J Allergy Clin Immunol 1997;99:450453.
  • 231
    Grembiale RD, Camporota L, Naty S, Tranfa CM, Djukanovic R, Marsico SA. Effects of specific immunotherapy in allergic rhinitic individuals with bronchial hyperresponsiveness. Am J Respir Crit Care Med 2000;162:20482052.
  • 232
    Niggemann B, Jacobsen L, Dreborg S, Ferdousi HA, Halken S, Host A et al. Five-year follow-up on the PAT study: specific immunotherapy and long-term prevention of asthma in children. Allergy 2006;61:855859.
  • 233
    Novembre E, Galli E, Landi F, Caffarelli C, Pifferi M, De ME et al. Coseasonal sublingual immunotherapy reduces the development of asthma in children with allergic rhinoconjunctivitis. J Allergy Clin Immunol 2004;114:851857.
  • 234
    Moller C, Dreborg S, Ferdousi HA, Halken S, Host A, Jacobsen L et al. Pollen immunotherapy reduces the development of asthma in children with seasonal rhinoconjunctivitis (the PAT-study). J Allergy Clin Immunol 2002;109:251256.
  • 235
    Durham SR, Walker SM, Varga EM, Jacobson MR, O’Brien F, Noble W et al. Long-term clinical efficacy of grass-pollen immunotherapy. N Engl J Med 1999;341:468475.
  • 236
    Eng PA, Reinhold M, Gnehm HP. Long-term efficacy of preseasonal grass pollen immunotherapy in children. Allergy 2002;57:306312.
  • 237
    Eng PA, Borer-Reinhold M, Heijnen IA, Gnehm HP. Twelve-year follow-up after discontinuation of preseasonal grass pollen immunotherapy in childhood. Allergy 2006;61:198201.
  • 238
    Petersen KD, Gyrd-Hansen D, Dahl R. Health-economic analyses of subcutaneous specific immunotherapy for grass pollen and mite allergy. Allergol Immunopathol (Madr) 2005;33:296302.
  • 239
    Olaguibel JM, Varez Puebla MJ. Efficacy of sublingual allergen vaccination for respiratory allergy in children. Conclusions from one meta-analysis. J Investig Allergol Clin Immunol 2005;15:916.
  • 240
    Di Rienzo V, Marcucci F, Puccinelli P, Parmiani S, Frati F, Sensi L et al. Long-lasting effect of sublingual immunotherapy in children with asthma due to house dust mite: a 10-year prospective study. Clin Exp Allergy 2003;33:206210.
  • 241
    Sopo SM, Macchiaiolo M, Zorzi G, Tripodi S. Sublingual immunotherapy in asthma and rhinoconjunctivitis; systematic review of paediatric literature. Arch Dis Child 2004;89:620624.
  • 242
    Bousquet J, Van CP, Khaltaev N. Allergic rhinitis and its impact on asthma. J Allergy Clin Immunol 2001;108:S147S334.
  • 243
    Penagos M, Compalati E, Tarantini F, Baena-Cagnani R, Huerta J, Passalacqua G et al. Efficacy of sublingual immunotherapy in the treatment of allergic rhinitis in pediatric patients 3 to 18 years of age: a meta-analysis of randomized, placebo-controlled, double-blind trials. Ann Allergy Asthma Immunol 2006;97:141148.
  • 244
    Eifan AO, Keles S, Bahceciler NN, Barlan IB. Anaphylaxis to multiple pollen allergen sublingual immunotherapy. Allergy 2007;62:567568.
  • 245
    Durham SR, Yang WH, Pedersen MR, Johansen N, Rak S. Sublingual immunotherapy with once-daily grass allergen tablets: a randomized controlled trial in seasonal allergic rhinoconjunctivitis. J Allergy Clin Immunol 2006;117:802809.
  • 246
    Bernstein DI, Wanner M, Borish L, Liss GM. Twelve-year survey of fatal reactions to allergen injections and skin testing: 1990-2001. J Allergy Clin Immunol 2004;113:11291136.
  • 247
    Khinchi MS, Poulsen LK, Carat F, Andre C, Hansen AB, Malling HJ. Clinical efficacy of sublingual and subcutaneous birch pollen allergen-specific immunotherapy: a randomized, placebo-controlled, double-blind, double-dummy study. Allergy 2004;59:4553.
  • 248
    Mungan D, Misirligil Z, Gurbuz L. Comparison of the efficacy of subcutaneous and sublingual immunotherapy in mite-sensitive patients with rhinitis and asthma – a placebo controlled study. Ann Allergy Asthma Immunol 1999;82:485490.
  • 249
    Wolf FM, Guevara JP, Grum CM, Clark NM, Cates CJ. Educational interventions for asthma in children. Cochrane Database Syst Rev 2003;CD000326.
  • 250
    Holzheimer L, Mohay H, Masters IB. Educating young children about asthma: comparing the effectiveness of a developmentally appropriate asthma education video tape and picture book. Child Care Health Dev 1998;24:8599.
  • 251
    Ward A, Willey C, Andrade S. Patient education provided to asthmatic children: a historical cohort study of the implementation of NIH recommendations. J Asthma 2001;38:141147.
  • 252
    Gebert N, Hummelink R, Konning J, Staab D, Schmidt S, Szczepanski R et al. Efficacy of a self-management program for childhood asthma – a prospective controlled study. Patient Educ Couns 1998;35:213220.
  • 253
    McCann DC, McWhirter J, Coleman H, Calvert M, Warner JO. A controlled trial of a school-based intervention to improve asthma management. Eur Respir J 2006;27:921928.
  • 254
    Dekker FW, Dieleman FE, Kaptein AA, Mulder JD. Compliance with pulmonary medication in general practice. Eur Respir J 1993;6:886890.
  • 255
    Gibson NA, Ferguson AE, Aitchison TC, Paton JY. Compliance with inhaled asthma medication in preschool children. Thorax 1995;50:12741279.
  • 256
    Tal A, Levy N, Bearman JE. Methylprednisolone therapy for acute asthma in infants and toddlers: a controlled clinical trial. Pediatrics 1990;86:350356.
  • 257
    Rowe BH, Keller JL, Oxman AD. Effectiveness of steroid therapy in acute exacerbations of asthma: a meta-analysis. Am J Emerg Med 1992;10:301310.
  • 258
    Smith M, Iqbal S, Elliott TM, Everard M, Rowe BH. Corticosteroids for hospitalised children with acute asthma. Cochrane Database Syst Rev 2003;CD002886.
  • 259
    Shim CS, Williams MH Jr. Relationship of wheezing to the severity of obstruction in asthma. Arch Intern Med 1983;143:890892.
  • 260
    Expert Panel Report 3 (EPR 3): Guidelines for the Diagnosis and Management of Asthma. National Heart Lung and Blood Institute 2007.; accessed 7 November 2007.
  • 261
    McGhan SL, MacDonald C, James DE, Naidu P, Wong E, Sharpe H et al. Factors associated with poor asthma control in children aged five to 13 years. Can Respir J 2006;13:2329.
  • 262
    Ducharme FM, Davis GM, Noya F, Rich H, Ernst P. The Asthma Quiz for Kidz: a validated tool to appreciate the level of asthma control in children. Can Respir J 2004;11:541546.
  • 263
    Nathan RA, Sorkness CA, Kosinski M, Schatz M, Li JT, Marcus P et al. Development of the asthma control test: a survey for assessing asthma control. J Allergy Clin Immunol 2004;113:5965.
  • 264
    Schatz M, Sorkness CA, Li JT, Marcus P, Murray JJ, Nathan RA et al. Asthma Control Test: reliability, validity, and responsiveness in patients not previously followed by asthma specialists. J Allergy Clin Immunol 2006;117:549556.
  • 265
    Liu AH, Zeiger R, Sorkness C, Mahr T, Ostrom N, Burgess S et al. Development and cross-sectional validation of the Childhood Asthma Control Test. J Allergy Clin Immunol 2007;119:817825.
  • 266
    Guyatt GH, Juniper EF, Griffith LE, Feeny DH, Ferrie PJ. Children and adult perceptions of childhood asthma. Pediatrics 1997;99:165168.
  • 267
    Hyland ME, Kenyon CA, Allen R, Howarth P. Diary keeping in asthma: comparison of written and electronic methods. BMJ 1993;306:487489.
  • 268
    Jones C, Santanello NC, Boccuzzi SJ, Wogen J, Strub P, Nelsen LM. Adherence to prescribed treatment for asthma: evidence from pharmacy benefits data. J Asthma 2003;40:93101.
  • 269
    Burkhart PV, Rayens MK, Bowman RK. An evaluation of children’s metered-dose inhaler technique for asthma medications. Nurs Clin North Am 2005;40:167182.
  • 270
    Lloyd BW, Ali MH. How useful do parents find home peak flow monitoring for children with asthma? BMJ 1992;305:11281129.
  • 271
    Wensley D, Silverman M. Peak flow monitoring for guided self-management in childhood asthma: a randomized controlled trial. Am J Respir Crit Care Med 2004;170:606612.
  • 272
    Kamps AW, Roorda RJ, Brand PL. Peak flow diaries in childhood asthma are unreliable. Thorax 2001;56:180182.
  • 273
    Sly PD, Flack F. Is home monitoring of lung function worthwhile for children with asthma? Thorax 2001;56:164165.
  • 274
    Fuhlbrigge AL, Kitch BT, Paltiel AD, Kuntz KM, Neumann PJ, Dockery DW et al. FEV(1) is associated with risk of asthma attacks in a pediatric population. J Allergy Clin Immunol 2001;107:6167.
  • 275
    Zanconato S, Meneghelli G, Braga R, Zacchello F, Baraldi E. Office spirometry in primary care pediatrics: a pilot study. Pediatrics 2005;116:e792e797.
  • 276
    Randolph C, Fraser B, Matasavage C. The free running athletic screening test as a screening test for exercise-induced asthma in high school. Allergy Asthma Proc 1997;18:9398.
  • 277
    Williams D, Bruton J, Wilson I. Screening a state middle school for asthma using the free running asthma screening test. Arch Dis Child 1993;69:667669.
  • 278
    Crapo RO, Casaburi R, Coates AL, Enright PL, Hankinson JL, Irvin CG et al. Guidelines for methacholine and exercise challenge testing-1999. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, July 1999. Am J Respir Crit Care Med 2000;161:309329.
  • 279
    Taylor DR, Pijnenburg MW, Smith AD, De Jongste JC. Exhaled nitric oxide measurements: clinical application and interpretation. Thorax 2006;61:817827.
  • 280
    Strunk RC, Szefler SJ, Phillips BR, Zeiger RS, Chinchilli VM, Larsen G et al. Relationship of exhaled nitric oxide to clinical and inflammatory markers of persistent asthma in children. J Allergy Clin Immunol 2003;112:883892.
  • 281
    Berry MA, Shaw DE, Green RH, Brightling CE, Wardlaw AJ, Pavord ID. The use of exhaled nitric oxide concentration to identify eosinophilic airway inflammation: an observational study in adults with asthma. Clin Exp Allergy 2005;35:11751179.
  • 282
    Zeiger RS, Szefler SJ, Phillips BR, Schatz M, Martinez FD, Chinchilli VM et al. Response profiles to fluticasone and montelukast in mild-to-moderate persistent childhood asthma. J Allergy Clin Immunol 2006;117:4552.
  • 283
    De Jongste JC. Yes to NO: the first studies on exhaled nitric oxide-driven asthma treatment. Eur Respir J 2005;26:379381.
  • 284
    Pijnenburg MW, Bakker EM, Hop WC, De Jongste JC. Titrating steroids on exhaled nitric oxide in children with asthma: a randomized controlled trial. Am J Respir Crit Care Med 2005;172:831836.
  • 285
    Smith AD, Cowan JO, Brassett KP, Herbison GP, Taylor DR. Use of exhaled nitric oxide measurements to guide treatment in chronic asthma. N Engl J Med 2005;352:21632173.
  • 286
    Pijnenburg MW, Hofhuis W, Hop WC, De Jongste JC. Exhaled nitric oxide predicts asthma relapse in children with clinical asthma remission. Thorax 2005;60:215218.
  • 287
    Zacharasiewicz A, Wilson N, Lex C, Erin EM, Li AM, Hansel T et al. Clinical use of noninvasive measurements of airway inflammation in steroid reduction in children. Am J Respir Crit Care Med 2005;171:10771082.
  • 288
    Scadding G. Nitric oxide in the airways. Curr Opin Otolaryngol Head Neck Surg 2007;15:258263.
  • 289
    ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide. Am J Respir Crit Care Med 2005;171:912930.
  • 290
    Baraldi E, De Jongste JC. Measurement of exhaled nitric oxide in children, 2001. Eur Respir J 2002;20:223237.
  • 291
    Buchvald F, Baraldi E, Carraro S, Gaston B, De JJ, Pijnenburg MW et al. Measurements of exhaled nitric oxide in healthy subjects age 4 to 17 years. J Allergy Clin Immunol 2005;115:11301136.
  • 292
    Horvath I, Hunt J, Barnes PJ, Alving K, Antczak A, Baraldi E et al. Exhaled breath condensate: methodological recommendations and unresolved questions. Eur Respir J 2005;26:523548.