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Keywords:

  • allergen skin test;
  • allergen-specific IgE;
  • anaphylaxis;
  • food allergy;
  • insect venom allergy;
  • tryptase

 Effector mechanisms in anaphylaxis were reviewed. Current approaches to confirmation of the clinical diagnosis were discussed. Improved methods for distinguishing between allergen sensitization (which is common in the general population) and clinical risk of anaphylaxis (which is uncommon) were deliberated. Innovative techniques that will improve risk assessment in anaphylaxis in the future were described.