Association of obesity and insulin resistance with asthma and aeroallergen sensitization
Article first published online: 3 APR 2008
© 2008 The Authors
Volume 63, Issue 5, pages 575–582, May 2008
How to Cite
Husemoen, L. L. N., Glümer, C., Lau, C., Pisinger, C., Mørch, L. S. and Linneberg, A. (2008), Association of obesity and insulin resistance with asthma and aeroallergen sensitization. Allergy, 63: 575–582. doi: 10.1111/j.1398-9995.2007.01613.x
- Issue published online: 3 APR 2008
- Article first published online: 3 APR 2008
- Accepted for publication 2 November 2007
- aeroallergen sensitization;
- insulin resistance;
Background: It has been hypothesized that obesity and insulin resistance may play a role in the development of asthma and allergy. The aim of the study was to examine the association of obesity and insulin resistance with asthma and aeroallergen sensitization.
Methods: Cross-sectional population-based study of 3609 Danish men and women aged 30–60 years. Aeroallergen sensitization was defined as positive levels of specific IgE against a panel of inhalant allergens. Asthma was defined as self-reported physician diagnosed asthma. Allergic asthma was defined as the presence of both asthma and aeroallergen sensitization. The homeostasis model assessment of insulin resistance was used to estimate the degree of insulin resistance. Body mass index, waist-to-hip ratio, and waist circumference were used as measures of obesity. Data were analyzed by multiple logistic regression analyses.
Results: Obesity was associated with increased risk of aeroallergen sensitization as well as allergic and nonallergic asthma. Insulin resistance was asssociated with aeroallergen sensitization and allergic asthma, but not nonallergic asthma. The associations of obesity with aeroallegen sensitization and allergic asthma became nonsignificant after adjustment for insulin resistance, whereas the association of obesity with nonallergic asthma was unaffected. No sex-differences were observed.
Conclusion: Obesity may be related to an increased risk of aeroallergen sensitization and allergic asthma through mechanisms also involved in the development of insulin resistance.