• 1
    Dust mite allergens and asthma – a worldwide problem. Report of an international workshop. J Allergy Clin Immunol 1989;83:416427.
  • 2
    Tovey ER. Allergen exposure and control. Exp Appl Acarol 1992;16:181202.
  • 3
    Custovic A, Simpson A, Chapman MD, Woodcock A. Allergen avoidance in the treatment of asthma and atopic disorders. Thorax 1998;53:6372.
  • 4
    Gøtzsche PC, Hammarquist C, Burr M. House dust mite control measures in the management of asthma: meta-analysis. BMJ 1998;317:11051110.
  • 5
    Hammarquist C, Burr ML, Gøtzsche PC. House dust mites and control measures in the management of asthma. Cochrane Database Syst Rev 1998; Issue 3.
  • 6
    Gøtzsche PC, Johansen HK. House dust mite control measures for asthma. Cochrane Database Syst Rev 2008; Issue 1: CD001187.
  • 7
    Review Manager (RevMan) [Computer program]. Version 4.2 for Windows. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2003.
  • 8
    Higgins JPT, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med 2002; 21: 15391558.
  • 9
    Bland JM, Altman DG. Measurement error proportional to the mean. BMJ 1996;313:106.
  • 10
    Gøtzsche PC. Believability of relative risks and odds ratios in abstracts: cross-sectional study. BMJ 2006;333:231234.
  • 11
    Gøtzsche PC. Bias in double-blind trials (thesis). Dan Med Bull 1990;37:329336.
  • 12
    Antonicelli L, Bilo MB, Pucci S, Schou C, Bonifazi F. Efficacy of an air-cleaning device equipped with a high efficiency particulate air filter in house dust mite respiratory allergy. Allergy 1991;46:594600.
  • 13
    Bahir A, Goldberg A, Mekori YA, Confino Cohen R, Morag H, Rosen Y et al. Continuous avoidance measures with or without acaricide in dust mite-allergic asthmatic children. Ann Allergy Asthma Immunol 1997;78:506512.
  • 14
    Burr ML, St Leger AS, Neale E. Anti-mite measurements in mite-sensitive adult asthma. A controlled trial. Lancet 1976;1:333335.
  • 15
    Burr ML, Dean BV, Merrett TG, Neale E, St Leger AS, Verrier-Jones ER. Effects of anti-mite measures on children with mite-sensitive asthma: a controlled trial. Thorax 1980;35:506512.
  • 16
    Burr ML, Neale E, Dean BV, Verrier-Jones ER. Effect of a change to mite-free bedding on children with mite-sensitive asthma: a controlled trial. Thorax 1980;35:513514.
  • 17
    Carswell F, Birmingham K, Oliver J, Crewes A, Weeks J. The respiratory effects of reduction of mite allergen in the bedrooms of asthmatic children – a double-blind controlled trial. Clin Exp Allergy 1996;26:386396.
  • 18
    Carswell F, Razif A, Oliver J, Crewes A, Birmingham K, Weeks J. The effect of allergen avoidance on mattress Der pI content and bronchial reactivity in mite sensitive asthmatic children. Ann Allergy 1994;72:74 (abstract 88).
  • 19
    Carswell F, Weeks J, Birmingham K. Reduced mite allergen exposure in the child’s bedroom improves the respiratory health of sensitive asthmatics. Allergy 1996;51(Suppl. 31):38.
  • 20
    Carswell F, Weeks J, Oliver J. Mite-sensitive asthmatic children’s response to mite allergen removal over a 6-month period: changes in respiratory indices [abstract]. Eur Respir J 1995;8(Suppl. 19):572S (abstract P2801).
  • 21
    Chang JH, Becker A, Ferguson A, Manfreda J, Simons E, Chan H et al. Effect of application of benzyl benzoate on house dust mite allergen levels. Ann Allergy Asthma Immunol 1996;77:187190.
  • 22
    Charpin D, Birnbaum J, Haddi E, N’Guyen A, Fondarai J, Vervloet D. Evaluation de l’ efficacite d’ un acaricide, Acardust, dans le traitement de l’ allergie aux acariens. Revue Française d’Allergologie 1990;30:149155.
  • 23
    Chen CC, Hsieh K-H. Effects of Microstop-treated anti-mite bedding on children with mite-sensitive asthma. Acta Paediatr Sin 1996;37:420427.
  • 24
    Cinti C, Canessa PA, Lavecchia MA, Capecchi V. Efficacia di un coprimaterasso e copricuscino ‘antiacaro’ nel controllo dell’asma dei pazienti allergici al dermatophagoides. Lotta Contro La Tuberculosi e Le Malattie Polmonari Sociali 1996;66:131138.
  • 25
    Cloosterman SG, Schermer TR, Bijl Hofland ID, Van Der Heide S, Brunekreef B, Van Den Elshout FJ et al. Effects of house dust mite avoidance measures on Der p 1 concentrations and clinical condition of mild adult house dust mite-allergic asthmatic patients, using no inhaled steroids. Clin Exp Allergy 1999;29:13361346.
  • 26
    Cloosterman SG, Schermer TR, Hofland ID, Van Der Heide S, Brune-Kreef B, Van Der Elshout FJ et al. Contribution of separate house dust mite avoidance measures in improving the clinical condition of asthmatic patients [abstract]. Eur Respir J 1996;9(Suppl. 23):394s.
  • 27
    De Vries MP, Van den Bemt L, Aretz K, Thoonen BP, Muris JW, Kester AD et al. House dust mite allergen avoidance and self-management in allergic patients with asthma: randomised controlled trial. Br J Gen Pract 2007;57:184190.
  • 28
    Dharmage S, Walters EH, Thien F, Bailey M, Raven J, Wharton C et al. Encasement of bedding does not improve asthma in atopic adult asthmatics. Int Arch Allergy Immunol 2006;139:132138.
  • 29
    Dietemann A, Bessot JC, Hoyet C, Ott M, Verot A, Pauli G. A double-blind, placebo controlled trial of solidified benzyl benzoate applied in dwellings of asthmatic patients sensitive to mites: clinical efficacy and effect on mite allergens. J Allergy Clin Immunol 1993;91:738746.
  • 30
    Dietemann A, Bessot JC, Hoyet C, Pauli G. A double blind placebo controlled study of the acaricidal agent Acarosan R: clinical efficacy in mite asthma. Allergy 1992;47(Suppl. 12):251 (abstract PS13).
  • 31
    Dietemann-Molard A, Bessot JC, Ott M, Hoyet C, Pauli G. Etude de l’efficacite clinique et biologique d’un nouvel acaricide (Acarosan®) chez des patients asthmatiques sensibilises a dermatophagoides pteronyssinus (DP). Rev Mal Respir 1991;8(Suppl. 1):R16 (abstract A53).
  • 32
    Dorward AJ, Colloff MJ, MacKay NS, McSharry C, Thomson NC. Effect of house dust mite avoidance measures on adult atopic asthma. Thorax 1988;43:98102.
  • 33
    Ehnert B, Lau-Schadendorf S, Weber A, Buettner P, Schou C, Wahn U. Reducing domestic exposure to dust mite allergen reduces bronchial hyperreactivity in sensitive children with asthma. J Allergy Clin Immunol 1992;90:135138.
  • 34
    Fang Z, Cai Y, Wang L. [The efficacy of controlling of house dusts in attacks of mite sensitive asthmatics]. Zhonghua Jie He He Hu Xi Za Zhi 2001;24:685689.
  • 35
    Frederick JM, Warner JO, Jessop WJ, Enander I, Warner JA. Effect of a bed covering system in children with asthma and house dust mite hypersensitivity. Eur Respir J 1997;10:361366.
  • 36
    Geller-Bernstein C, Pibourdin JM, Dornelas A, Fondarai J. Efficacy of the acaricide : acardust for the prevention of asthma and rhinitis due to dust mite allergy, in children. Allerg Immunol 1995;27:147154.
  • 37
    Ghazala L, Schmid F, Helbling A, Pichler WJ, Pichler CE. Efficacy of house dust mite- and allergen-impermeable encasings in patients with house dust mite allergy. Allergologie 2004;27:2634.
  • 38
    Gillies DRN, Littlewood JM, Sarsfield JK. Controlled trial of house dust mite avoidance in children with mild to moderate asthma. Allergy Immunol 1987;17:105111.
  • 39
    Halken S, Host A, Niklassen U, Hansen LG, Nielsen F, Pedersen S et al. Effect of mattress and pillow encasings on children with asthma and house dust mite allergy. J Allergy Clin Immunol 2003;111:169176.
  • 40
    Halken S, Høst A. Are encasings effective in asthma caused by house dust mite allergens (reply)? J Allergy Clin Immunol 2003;112:220221.
  • 41
    Halken S, Niklassen U, Hansen LG, Nielsen F, Høst A, Østerballe O et al. Encasing of mattresses in children with asthma and house dust mite allergy [abstract]. J Allergy Clin Immunol 1997;99:S320.
  • 42
    Howarth P, Lunn A, Tomkin S. Bedding barrier intervention in house dust mite respiratory allergy. Clin Exp Allergy 1992;22:140.
  • 43
    Htut T, Higenbottam TW, Gill G, Darwin R, Anderson PB, Syed N. Six month’s report on mite-allergen eradication trial [abstract]. Eur Respir J 1998;12(Suppl. 28):69s (abstract P0512).
  • 44
    Htut T, Higenbottam TW, Gill G, Darwin R, Anderson PB, Syed N. Mite eradication trial: a double blind randomised study. European Respiratory Society, Oct 9–13, Madrid, Spain, 1999:334s; abstract P2253.
  • 45
    Htut T, Higenbottam TW, Gill GW, Darwin R, Anderson PB, Syed N. Eradication of house dust mite from homes of atopic asthmatic subjects: a double-blind trial. J Allergy Clin Immunol 2001;107:5560.
  • 46
    Htut T, Higenbottam TW, Gill GW, Darwin R, Anderson PB, Syed N. Impact of mite eradication in homes on bronchial hyperresponsiveness of adult asthmatics. Thorax 1999;54(Suppl. 3):A28; abstract P40.
  • 47
    Huss K, Squire EN, Carpenter GB, Smith LJ, Huss RW, Salata K et al. Effective education of adults with asthma who are allergic to dust mites. J Allergy Clin Immunol 1992;89:836843.
  • 48
    Jooma OF, Weinberg EG, Berman D, Manjra AI, Potter PC. Accumulation of house-dust mite (Der-p-1) levels on mattress covers. S Afr Med J 1995;85:10021005.
  • 49
    Korsgaard J. Preventive measures in mite asthma. A controlled trial. Allergy 1983;38:93102.
  • 50
    Kroidl RF, Gobel D, Balzer D, Trendelenburg F, Schwichtenberg U. Clinical effects of benzyl benzoate in the prevention of house-dust-mite allergy. Results of a prospective, double-blind, multicenter study. Allergy 1998;53:435440.
  • 51
    Lee IS, Moon JS, Yoo YS. Effectiveness of bedding control instruction for patients with respiratory allergies: a randomized controlled trial. Int J Nurs Stud 2006;doi:10.1016/j.ijnurstu.2006.08.009.
  • 52
    Lee IS. Effect of bedding control on amount of house dust mite allergens, asthma symptoms, and peak expiratory flow rate. Yonsei Med J 2003;44:313322.
  • 53
    Luczynska C, Tredwell E, Smeeton N, Burney P. A randomized controlled trial of mite allergen-impermeable bed covers in adult mite-sensitized asthmatics. Clin Exp Allergy 2003;33:16481653.
  • 54
    Maesen FPV, Sluysmans FG, Brombacher PJ, Smeets JJ. Ervaringen met het gebruik van luchtfiltratieapparatuur in de woonruimten van voor huisstof overgevoelige atopische patienten. Acta tuberculosea et pneumologica Belgica 1977;68:133147.
  • 55
    Manjra A, Berman D, Toerien A, Weinberg EG, Potter PC. The effects of a single treatment of an acaricide, Acarosan, and a detergent, Metsan, on Der p 1 allergen levels in the carpets and mattresses of asthmatic children. S Afr Med J 1994;84:278280.
  • 56
    Marks GB, Tovey ER, Green W, Shearer M, Salome CM, Woolcock AJ. The effect of changes in house dust mite allergen exposure on the severity of asthma. Clin Exp Allergy 1995;25:114118.
  • 57
    Marks GB, Tovey ER, Green W, Shearer M, Salome CM, Woolcock AJ. House dust mite allergen avoidance: a randomized controlled trial of surface chemical treatment and encasement of bedding. Clin Exp Allergy 1994;24:10781083.
  • 58
    Matthys H, Hupert A, Busch B. Dry air in bedrooms of patients with house dust mite-induced asthma. Eur Respir J 1996;9(Suppl. 23):350s (abstract P2175).
  • 59
    Mitchell EA, Elliott RB. Controlled trial of an electrostatic precipitator in childhood asthma. Lancet 1980;2:559561.
  • 60
    Popplewell EJ, Innes VA, Lloyd-Hughes S, Jenkins EL, Khdir K, Bryant TN et al. The effect of high-efficiency and standard vacuum-cleaners on mite, cat and dog allergen levels and clinical progress. Pediatr Allergy Immunol 2000;11:142148.
  • 61
    Reiser J, Ingram D, Mitchell EB, Warner JO. House dust mite allergen levels and an anti-mite mattress spray (natamycin) in the treatment of childhood asthma. Clin Exp Allergy 1990;20:561567.
  • 62
    Rijssenbeek-Nouwens LH, Oosting AJ, De Bruin-Weller MS, Bregman I, De Monchy JG, Postma DS. Clinical evaluation of the effect of anti-allergic mattress covers in patients with moderate to severe asthma and house dust mite allergy: a randomised double blind placebo controlled study. Thorax 2002;57:784790.
  • 63
    Rijssenbeek-Nouwens LH, Oosting AJ, De Monchy JG, Bregman I, Postma DS, De Bruin-Weller MS. The effect of anti-allergic mattress encasings on house dust mite-induced early- and late-airway reactions in asthmatic patients. A double-blind, placebo-controlled study. Clin Exp Allergy 2002;32:117125.
  • 64
    Sette L, Comis A, Marcucci F, Sensi L, Piacentini GL, Boner AL. Benzyl-bensoate foam: effects on mite allergens in mattress, serum and nasal secretory IgE to Dermatophagoides pteronyssinus, and bronchial hyperreactivity in children with allergic asthma. Pediatr Pulmonol 1994;18:218227.
  • 65
    Shapiro GG, Wighton TG, Chinn T, Zuckrman J, Eliassen AH, Picciano JF et al. House dust mite avoidance for children with asthma in homes of low-income families. J Allergy Clin Immunol 1999;103:10691074.
  • 66
    Sheikh A, Hurwitz B, Sibbald B, Barnes G, Howe M, Durham S. House dust mite barrier bedding for childhood asthma: randomised placebo controlled trial in primary care. BMC Fam Pract 2002;3:12.
  • 67
    Sooltangos S, Khodaboccus F, Baligadoo S, Leynadier F, Fadel R. Effect of house dust mites (HDM) avoidance measures on symptoms of asthmatic patients in Island of Mauritius. J Allergy Clin Immunol 1992;89:259.
  • 68
    Thiam DG, Tim CF, Hoon LS, Lei Z, Bee-Wah L. An evaluation of mattress encasings and high efficiency particulate filters on asthma control in the tropics. Asian Pac J Allergy Immunol 1999;17:169174.
  • 69
    Van den Bemt L, Jansen M, Van Knapen L, Cloostermann S, De Vries M, Van Schayck O. Effectiveness of a mite-allergen impermeable (non-polyurethane) bed covering system in asthmatic mite-sensitive patients (abstract). Eur Respir J 2000;16:468S.
  • 70
    Van den Bemt L, Van Knapen L, De Vries MP, Jansen M, Cloosterman S, Van Schayck CP. Clinical effectiveness of a mite allergen-impermeable bed-covering system in asthmatic mite-sensitive patients. J Allergy Clin Immunol 2004;114:858862.
  • 71
    Van der Heide S, Kaufmann HF, Dubois AEJ, De Monchy JGR. Allergen-avoidance measures in homes of house-dust-mite-allergic asthmatic patients: effects of acaricides and mattress encasings. Allergy 1997;52:921927.
  • 72
    Van der Heide S, Kauffman HF, Dubois AE, De Monchy JG. Allergen reduction measures in houses of allergic asthmatic patients: effects of air-cleaners and allergen-impermeable mattress covers. Eur Respir J 1997;10:12171223.
  • 73
    Van der Heide S, Van Aalderen WM, Kauffman HF, Dubois AE, De Monchy JG. Clinical effects of air cleaners in homes of asthmatic children sensitized to pet allergens. J Allergy Clin Immunol 1999;104(2 Pt 1):447451.
  • 74
    Verrall B, Muir DC, Wilson WM, Milner R, Johnston M, Dolovitch J. Laminar flow air cleaner bed attachment: a controlled trial. Ann Allergy 1988;61:117122.
  • 75
    Walshaw MJ, Evans CC. Allergen avoidance in house dust mite sensitive adult asthma. Q J Med 1986;58:199215.
  • 76
    Warburton CJ, Niven RMcL, Pickering CA, Fletcher AM, Hepworth J, Francis HC. Domiciliary air filtration units, symptoms and lung function in atopic asthmatics. Respir Med 1994;88:771776.
  • 77
    Warner JA, Marchant JL, Warner JO. Double blind trial of ionisers in children with asthma sensitive to the house dust mite. Thorax 1993;48:330333.
  • 78
    Warner JA, Frederick JM, Bryant TN, Weich C, Raw GJ, Hunter C et al. Mechanical ventilation and high-efficiency vacuum cleaning: a combined strategy of mite and mite allergen reduction in the control of mite-sensitive asthma. J Allergy Clin Immunol 2000;105 (1 pt 1):7582.
  • 79
    Custovic A, Forster L, Matthews E, Martin J, Letley L, Vickers M et al. The effect of mite allergen control by the use of allergen-impermeable covers in adult asthma: the SMAC trial. Thorax 2002;57:iii45.
  • 80
    Woodcock A, Forster L, Matthews E, Martin J, Letley L, Vickers M et al. Control of exposure to mite allergen and allergen-impermeable bed covers for adults with asthma. N Engl J Med 2003;349:225236.
  • 81
    Zwemer RJ, Karibo J. Use of laminar control device as adjunct to standard environmental control measures in symptomatic asthmatic children. Ann Allergy 1973;31:284290.
  • 82
    Gøtzsche PC, Johansen HK, Burr M. Are encasings effective in asthma caused by house dust mite allergens (letter)? J Allergy Clin Immunol 2003;112:220.
  • 83
    Chan A-W, Hróbjartsson A, Haahr MT, Gøtzsche PC, Altman DG. Empirical evidence for selective reporting of outcomes in randomized trials: comparison of protocols to published articles. JAMA 2004;291:24572465.
  • 84
    Naspitz CK, Diniz C, Rizzo MC, Fernandez-Caldas E, Sole D. Human scalps as a reservoir of domestic mites. Lancet 1997;349:404.
  • 85
    Ihre E, Axelsson IGK, Zetterström O. Late asthmatic reactions and bronchial variability after challenge with low doses of allergen. Clin Allergy 1988;18:557567.
  • 86
    Ihre E, Zetterstrom O. Increase in non-specific bronchial responsiveness after repeated inhalation of low doses of allergen. Clin Exp Allergy 1993;23:298305.
  • 87
    Pildal J, Hrobjartsson A, Jorgensen KJ, Hilden J, Altman DG, Gotzsche PC. Impact of allocation concealment on conclusions drawn from meta-analyses of randomized trials. Int J Epidemiol 2007;36:847857.
  • 88
    Morgan WJ, Crain EF, Gruchalla RS, O’Connor GT, Kattan M, Evans R et al. Results of a home-based environmental intervention among urban children with asthma. N Engl J Med 2004;351:10681080.
  • 89
    Van Schayck OC, Maas T, Kaper J, Knottnerus AJ, Sheikh A. Is there any role for allergen avoidance in the primary prevention of childhood asthma? J Allergy Clin Immunol 2007;119:13231328.
  • 90
    Schmidt LM, Gøtzsche PC. Of mites and men: reference bias in narrative review articles: a systematic review. J Fam Pract 2005;54:334338.
  • 91
    Murray AB, Ferguson AC. Dust-free bedrooms in the treatment of asthmatic children with house dust or house dust mite allergy: a controlled trial. Pediatrics 1983;71:418422.
  • 92
    National Heart, Lung, and Blood Institute; National Asthma Education and Prevention Program. Expert panel report 3: guidelines for the diagnosis and management of asthma. Washington, DC: US Department of Health, 2007. (accessed Sept 13, 2007).
  • 93
    Gøtzsche PC. Asthma guidelines on house dust mites are not evidence-based. Lancet 2007;370:21002101.
  • 94
    Bacharier LB, Boner A, Carlsen KH, Eigenmann PA, Frischer T, Götz M et al. Diagnosis and treatment of asthma in childhood: a PRACTALL consensus report. Allergy 2008;63:534.