• 1
    Kaliner MA, Osguthorpe JD, Fireman P, Anon J, Georgitis J, Davis ML et al. Sinusitis: bench to bedside – current findings, future directions. J Allergy Clin Immunol 1997;99:S829S848.
  • 2
    Fokkens W, Lund V, Mullol J. European Position Paper on Rhinosinusitis and Nasal polyps group. European position paper on rhinosinusitis and nasal polyps 2007. Rhinol Suppl 2007;20:1136.
  • 3
    Van Zele T, Claeys S, Gevaert P, Van Maele G, Holtappels G, Van Cauwenberge P et al. Differentiation of chronic sinus diseases by measurement of inflammatory mediators. Allergy 2006;61:12801289.
  • 4
    Lennard CM, Mann EA, Sun LL, Chang AS, Bolger WE. Interleukin-1β, interleukin-5, interleukin-6, interleukin-8, and tumor necrosis factor-α in chronic sinusitis: response to systemic corticosteroids. Am J Rhinol 2000;14:367373.
  • 5
    Denhardt DT, Noda M, O’Regan AW, Pavlin D, Berman JS. OPN as a means to cope with environmental insults: regulation of inflammation, tissue remodeling, and cell survival. J Clin Invest 2001;107:10551061.
  • 6
    Zhu B, Suzuki K, Goldberg HA, Rittling SR, Denhardt DT, McCulloch CA et al. OPN modulates CD44-dependent chemotaxis of peritoneal macrophages through G-protein-coupled receptors: evidence of a role for an intracellular form of OPN. J Cell Physiol 2004;198:155167.
  • 7
    O’Regan AW, Nau GJ, Chupp GL, Berman JS. OPN (Eta-1) in cell-mediated immunity: teaching an old dog new tricks. Immunol Today 2000;21:475478.
  • 8
    Patarca R, Saavedra RA, Cantor H. Molecular and cellular basis of genetic resistance to bacterial infection: the role of the early T-lymphocyte activation-1/osteopontin gene. Crit Rev Immunol 1993;13:225246.
  • 9
    Hur EM, Youssef S, Haws ME, Zhang SY, Sobel RA, Steinman L. Osteopontin-induced relapse and progression of autoimmune brain disease through enhanced survival of activated T cells. Nat Immunol 2007;8:7483.
  • 10
    Gassler N, Autschbach F, Gauer S, Bohn J, Sido B, Otto HF et al. Expression of osteopontin (Eta-1) in Crohn disease of the terminal ileum. Scand J Gastroenterol 2002;37:12861295.
  • 11
    Xu G, Nie H, Li N, Zheng W, Zhang D, Feng G et al. Role of osteopontin in amplification and perpetuation of rheumatoid synovitis. J Clin Invest 2005;115:10601067.
  • 12
    Xanthou G, Alissafi T, Semitekolou M, Simoes DCM, Economidou E, Gaga M et al. Osteopontin has a crucial role in allergic airway disease through regulation of dendritic cell subsets. Nat Med 2007;13:570578.
  • 13
    Kohan M, Bader R, Puxeddu I, Levi-Schaffer F, Breuer R, Berkman N. Enhanced osteopontin expression in a murine model of allergen-induced airway remodeling. Clin Exp Allergy 2007;37:14441454.
  • 14
    Meltzer EO, Hamilos DL, Hadley JA, Lanza DC, Marple BF, Nicklas RA et al. Rhinosinusitis: establishing definitions for clinical research and patientcare. J Allergy Clin Immunol 2004;114:155212.
  • 15
    Liu Z, Lu X, Wang H, Gao Q, Cui Y. The up-regulated expression of tenascin C in human nasal polyp tissues is related to eosinophil-derived transforming growth factor beta1. Am J Rhinol 2006;20:629633.
  • 16
    Liu Z, Lu X, Wang H, Gao Q, Cui Y. Group II subfamily secretory phospholipase A2 enzymes: expression in chronic rhinosinusitis with and without nasal polyps. Allergy 2007;62:9991006.
  • 17
    Hauber HP, Daigneault P, Frenkiel S, Lavigne F, Hung HL, Levitt RC et al. Niflumic acid and MSI-2216 reduce TNF-alpha-induced mucin expression in human airway mucosa. J Allergy Clin Immunol 2005;115:266271.
  • 18
    Sha Q, Truong-Tran AQ, Plitt JR, Beck LA, Schleimer RP. Activation of airway epithelial cells by toll-like receptor agonists. Am J Respir Cell Mol Biol 2004;31:358364.
  • 19
    Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-DeltaDelta C(T)) method. Methods 2001;25:402408.
  • 20
    Konno S, Eckman JA, Plunkett B, Li X, Berman JS, Schroeder J et al. Interleukin-10 and Th2 cytokines differentially regulate OPN expression in human monocytes and dendritic cells. J Interferon Cytokine Res 2006;26:562567.
  • 21
    O’Regan A, Berman JS. Osteopontin: a key cytokine in cell-mediated and granulomatous inflammation. Int J Exp Pathol 2000;81:373390.
  • 22
    Van Bruaene N, Perez-Novo CA, Basinski TM, Van Zele T, Holtappels G, Ruyck ND et al. T-cell regulation in chronic paranasal sinus disease. J Allergy Clin Immunol 2008;121:14351441.
  • 23
    Shinohara ML, Lu L, Bu J, Werneck MB, Kobayashi KS, Glimcher LH et al. Osteopontin expression is essential for the interferon-alpha production by plasmacytoid dendritic cells. Nat Immunol 2006;7:498506.