The polymorphisms of interleukin 17A (IL17A) gene and its association with pediatric asthma in Taiwanese population
Article first published online: 5 FEB 2009
© 2009 John Wiley & Sons A/S
Volume 64, Issue 7, pages 1056–1060, July 2009
How to Cite
Wang, J. Y., Shyur, S. D., Wang, W. H., Liou, Y. H., Lin, C. G. J., Wu, Y. J. and Wu, L. S. H. (2009), The polymorphisms of interleukin 17A (IL17A) gene and its association with pediatric asthma in Taiwanese population. Allergy, 64: 1056–1060. doi: 10.1111/j.1398-9995.2009.01950.x
- Issue published online: 1 JUN 2009
- Article first published online: 5 FEB 2009
- Accepted for publication 2 October 2008
- single nucleotide polymorphism
Background: The interleukin 17A (IL17A) gene, located on chromosome 6p and linked to asthma phenotype, is a highly potential candidate gene conferring asthma susceptibility. The purpose of this study was to investigate the genetic association between single nucleotide polymorphisms (SNPs) of IL17A and asthma in Taiwanese children.
Methods: We selected and performed genotyping on nine SNPs that encompass the genomic region of IL17A in Taiwanese children with or without asthma. A total of 1939 subjects containing 1027 subjects in testing group and 931 subjects in validation group were recruited in this study.
Results: After Bonferroni correction, SNP rs8193036 was found to have a weak association (P = 0.0074 × 9 = 0.066) in genotype frequency test. This association was confirmed by validation group. Logistic regression adjusted allergy comorbidity and gender showed a slightly weaker association.
Conclusions: The results indicated an independent role of IL17A promoter polymorphism rs8193036 in the association with pediatric asthma in Taiwanese population.