Interleukin-12 family members and type I interferons in Th17-mediated inflammatory disorders


Michel Goldman
Institute for Medical Immunology
Université Libre de Bruxelles
8 rue Adrienne Bolland
B-6041 Charleroi


Cytokines produced by antigen-presenting cells govern the fate of helper T-cell responses. Herein, we review the impact of interleukin (IL)-23 and IL-27 on the outcome of T-helper (Th) 17 cell responses and discuss their impact in the pathogenesis of T-cell-mediated inflammatory disorders of autoimmune or allergic origin. We then discuss how type I interferons might influence the course of autoimmune diseases by tipping the balance between IL-12 family members.