• 1
    Bernstein IL, Storms WW. Practice parameters for allergy diagnostic testing Joint Task Force on Practice Parameters for the Diagnosis and Treatment of Asthma. The American Academy of Allergy, Asthma and Immunology and the American College of Allergy, Asthma and Immunology. Ann Allergy Asthma Immunol 1995;75:543625.
  • 2
    Esch RE. Allergen source materials and quality control of allergenic extracts. Methods 1997;13:213.
  • 3
    Eichler I, Gotz M, Jarisch R, Eichler HG, Moss R. Reproducibility of skin prick testing with allergen extracts from different manufacturers. Allergy 1988;43:458463.
  • 4
    Grier TJ, Hazelhurst DM, Duncan EA, West TK, Esch RE. Major allergen measurements: sources of variability, validation, quality assurance, and utility for laboratories, manufacturers, and clinics. Allergy Asthma Proc 2002;23:125131.
  • 5
    Focke M, Marth K, Flicker S, Valenta R. Heterogeneity of commercial timothy grass pollen extracts. Clin Exp Allergy 2008;38:14001408.
  • 6
    Focke M, Marth K, Valenta R. Molecular composition and biological activity of commercial birch pollen allergen extracts. Eur J Clin Invest 2009;39:429436.
  • 7
    Van Der Veen MJ, Mulder M, Witteman AM, Van Ree R, Aalberse RC, Jansen HM et al. False-positive skin prick test responses to commercially available dog dander extracts caused by contamination with house dust mite (Dermatophagoides pteronyssinus) allergens. J Allergy Clin Immunol 1996;98:10281034.
  • 8
    Mari A. Skin test with a timothy grass (Phleum pratense) pollen extract vs IgE to a timothy extract vs. IgE to rPhl p 1, rPhl p 2, nPhl p 4, rPhl p 5, rPhl p 6, rPhl p 7, rPhl p 11, and rPhl p 12: epidemiological and diagnostic data. Clin Exp Allergy 2003;33:4351.
  • 9
    Valenta R, Kraft D. From allergen structure to new forms of allergen-specific immunotherapy. Curr Opin Immunol 2002;14:718727.
  • 10
    Hiller R, Laffer S, Harwanegg C, Huber M, Schmidt WM, Twardosz A et al. Microarrayed allergen molecules: diagnostic gatekeepers for allergy treatment. FASEB J 2002;16:414416.
  • 11
    Mothes N, Valenta R, Spitzauer S. Allergy testing: the role of recombinant allergens. Clin Chem Lab Med 2006;44:125132.
  • 12
    Valenta R. Biochemistry of allergens and recombinant allergens. In: KayAB, KaplanA, BousquetJ, HoltP, editors. Allergy and Allergic Diseases. 2nd edn. Chichester: Wiley-Blackwell; 2008;895912.
  • 13
    Valenta R, Steinberger P, Duchene M, Kraft D. Immunological and structural similarities among allergens: prerequisite for a specific and component-based therapy of allergy. Immunol Cell Biol 1996;74:187194.
  • 14
    Pauli G. Evolution in the understanding of cross-reactivities of respiratory allergens: the role of recombinant allergens. Int Arch Allergy Immunol 2000;123:183195.
  • 15
    Radauer C, Breiteneder H. Pollen allergens are restricted to few protein families and show distinct patterns of species distribution. J Allergy Clin Immunol 2006;117:141147.
  • 16
    Mothes N, Horak F, Valenta R. Transition from a botanical to a molecular classification in tree pollen allergy: implications for diagnosis and therapy. Int Arch Allergy Immunol 2004;135:357373.
  • 17
    Kazemi-Shirazi L, Niederberger V, Linhart B, Lidholm J, Kraft D, Valenta R. Recombinant marker allergens: diagnostic gatekeepers for the treatment of allergy. Int Arch Allergy Immunol 2002;127:259268.
  • 18
    Vrtala S, Susani M, Sperr WR, Valent P, Laffer S, Dolecek C et al. Immunologic characterization of purified recombinant timothy grass pollen (Phleum pratense) allergens (Phl p 1, Phl p 2, Phl p 5). J Allergy Clin Immunol 1996;97:781787.
  • 19
    Andersson K, Lidholm J. Characteristics and immunobiology of grass pollen allergens. Int Arch Allergy Immunol 2003;130:87107.
  • 20
    Van Ree R, Van Leeuwen A, Aalberse RC. How far can we simplify in vitro diagnostics for grass pollen allergy ?: a study with 17 whole pollen extracts and purified natural and recombinant major allergens. J Allergy Clin Immunol 1998;102:184190.
  • 21
    Breiteneder H, Pettenburger K, Bito A, Valenta R, Kraft D, Rumpold H et al. The gene coding for the major birch pollen allergen Betv1, is highly homologous to a pea disease resistance response gene. EMBO J 1989;8:19351938.
  • 22
    Ebner C, Hirschwehr R, Bauer L, Breiteneder H, Valenta R, Ebner H et al. Identification of allergens in fruits and vegetables: IgE cross-reactivities with the important birch pollen allergens Bet v 1 and Bet v 2 (birch profilin). J Allergy Clin Immunol 1995;95:962969.
  • 23
    Niederberger V, Pauli G, Grönlund H, Fröschl R, Rumpold H, Kraft D et al. Recombinant birch pollen allergens (rBet v 1, rBet v 2) contain most of the IgE epitopes present in birch, alder, hornbeam, hazel, and oak pollen: a quantitative IgE inhibition study with sera from different populations. J Allergy Clin Immunol 1998;102:579591.
  • 24
    Valenta R, Duchene M, Pettenburger K, Sillaber C, Valent P, Bettelheim P et al. Identification of profilin as a novel pollen allergen; IgE autoreactivity in sensitized individuals. Science 1991;253:557560.
  • 25
    Tinghino R, Twardosz A, Barletta B, Puggioni EM, Iacovacci P, Butteroni C et al. Molecular, structural, and immunologic relationships between different families of recombinant calcium-binding pollen allergens. J Allergy Clin Immunol 2002;109:314320.
  • 26
    Valenta R, Hayek B, Seiberler S, Bugajska-Schretter A, Niederberger V, Twardosz A et al. Calcium-binding allergens: From plants to man. Int Arch Allergy Immunol 1998;117:160166.
  • 27
    Niederberger V, Hayek B, Vrtala S, Laffer S, Twardosz A, Vangelista L et al. Calcium-dependent immunoglobulin E recognition of the apo- and calcium-bound form of a cross-reactive two EF-hand timothy grass pollen allergen, Phl p 7. FASEB J 1999;13:843856.
  • 28
    Stern DA, Riedler J, Nowak D, Braun-Fahrlander C, Swoboda I, Balic N et al. Exposure to a farming environment has allergen-specific protective effects on TH2-dependent isotype switching in response to common inhalants. J Allergy Clin Immunol 2007;119:351358.
  • 29
    Niederberger V, Ring J, Rakoski J, Jager S, Spitzauer S, Valent P et al. Antigens drive memory IgE responses in human allergy via the nasal mucosa. Int Arch Allergy Immunol 2007;142:133144.
  • 30
    Kazemi-Shirazi L, Pauli G, Purohit A, Spitzauer S, Fröschl R, Hoffmann-Sommergruber K et al. Quantitative IgE inhibition experiments with purified recombinant allergens indicate pollen-derived allergens as the sensitizing agents responsible for many forms of plant food allergy. J Allergy Clin Immunol 2000;105:116125.
  • 31
    Bousquet J, Anto JM, Bachert C, Bousquet PJ, Colombo P, Crameri R et al. Factors responsible for differences between asymptomatic subjects and patients presenting an IgE sensitization to allergens A GA2LEN project. Allergy 2006;61:671680.
  • 32
    Niederberger V, Stübner P, Spitzauer S, Kraft D, Valenta R, Ehrenberger K et al. Skin test results but not serology reflect immediate type respiratory sensitivity: a study performed with recombinant allergen molecules. J Invest Dermatol 2001;117:848851.
  • 33
    Silvestri M, Rossi GA, Cozzani S, Pulvirenti G, Fasce L. Age-dependent tendency to become sensitized to other classes of aeroallergens in atopic asthmatic children. Ann Allergy Asthma Immunol 1999;83:335340.
  • 34
    Palomares O, Swoboda I, Villalba M, Balic N, Spitzauer S, Rodriguez R et al. The major allergen of olive pollen Ole e 1 is a diagnostic marker for sensitization to Oleaceae. Int Arch Allergy Immunol 2006;141:110118.
  • 35
    Stumvoll S, Westritschnig K, Lidholm J, Spitzauer S, Colombo P, Duro G et al. Identification of cross-reactive and genuine Parietaria judaica pollen allergens. J Allergy Clin Immunol 2003;111:974979.
  • 36
    Zuidmeer L, Van Leeuwen WA, Budde IK, Cornelissen J, Bulder I, Rafalska I, et al. Lipid transfer proteins from fruit: cloning, expression, and quantification. Int Arch Allergy Immunol 2005;137:273281.
  • 37
    Moverare R, Westritschnig K, Svensson M, Hayek B, Bende M, Pauli G et al. Different IgE reactivity profiles in birch pollen-sensitive patients from six European populations revealed by recombinant allergens: an imprint of local sensitization. Int Arch Allergy Immunol 2002;128:325335.