Interferon-gamma and IL-10 may protect from allergic polysensitization in children: preliminary evidence

Authors


  • Edited by: Wytske Fokkens

G. Ciprandi, MD, Semeiotica e Metodologia Medica I, DIMI Viale Benedetto XV 6, 16132 Genoa, Italy.
Tel.: +39 10 3533 8120
Fax: +39 10 3538 7573
E-mail: gio.cip@libero.it

Abstract

To cite this article: Prigione I, Morandi F, Tosca MA, Silvestri M, Pistoia V, Ciprandi G, Rossi GA. Interferon-gamma and IL-10 may protect from allergic polysensitization in children: preliminary evidence. Allergy 2010; 65: 740–742.

Abstract

Background:  A functional defect of T regulatory cells (Treg) has been proposed as pathogenic mechanism of allergic reaction. Polysensitization is a common feature of allergic patients.

Aim of the study:  It was to investigate the possible role of Treg-Th1 cytokines, in the development of new sensitizations in childhood.

Methods:  Forty monosensitized (MS) children with allergic rhinitis were evaluated and followed-up for 2 years. New sensitizations were investigated. IL-10 and IFN-γ were evaluated in in vitro experiments.

Results:  Children remaining MS showed significant higher production of both IL-10 and IFN-γ.

Conclusion:  This preliminary study provided evidence that IL-10 and IFN-γ production could be defective in allergic children prone to develop polysensitization.

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