• 1
    Broide D. New perspectives on mechanisms underlying chronic allergic inflammation and asthma in 2007. J Allergy Clin Immunol 2008;122:475480.
  • 2
    Brightling CE, Bradding P, Symon FA, Holgate ST, Wardlaw AJ, Pavord ID. Mast-cell infiltration of airway smooth muscle in asthma. N Engl J Med 2002;346:16991705.
  • 3
    Carroll NG, Mutavdzic S, James AL. Distribution and degranulation of airway mast cells in normal and asthmatic subjects. Eur Respir J 2002;19:879885.
  • 4
    Berger P, Girodet PO, Begueret H, Ousova O, Perng DW, Marthan R et al. Tryptase-stimulated human airway smooth muscle cells induce cytokine synthesis and mast cell chemotaxis. FASEB J 2003;17:21392141.
  • 5
    Brightling CE, Ammit AJ, Kaur D, Black JL, Wardlaw AJ, Hughes JM et al. The CXCL10/CXCR3 Axis Mediates Human Lung Mast Cell Migration to Asthmatic Airway Smooth Muscle. Am J Respir Crit Care Med 2005;171:11031108.
  • 6
    El-Shazly A, Berger P, Girodet PO, Ousova O, Fayon M, Vernejoux JM et al. Fraktalkine produced by airway smooth muscle cells contributes to mast cell recruitment in asthma. J Immunol 2006;176:18601868.
  • 7
    Begueret H, Berger P, Vernejoux JM, Dubuisson L, Marthan R, Tunon-de-Lara JM. Inflammation of bronchial smooth muscle in allergic asthma. Thorax 2007;62:815.
  • 8
    Bradding P, Walls AF, Holgate ST. The role of the mast cell in the pathophysiology of asthma. J Allergy Clin Immunol 2006; 117:12771284.
  • 9
    Thangam EB, Venkatesha RT, Zaidi AK, Jordan-Sciutto KL, Goncharov DA, Krymskaya VP et al. Airway smooth muscle cells enhance C3a-induced mast cell degranulation following cell-cell contact. FASEB J 2005;19:798800.
  • 10
    Yang W, Kaur D, Okayama Y, Ito A, Wardlaw AJ, Brightling CE et al. Human lung mast cells adhere to human airway smooth muscle, in part, via tumor suppressor in lung cancer-1. J Immunol 2006;176:12381243.
  • 11
    Hollins F, Kaur D, Yang W, Cruse G, Saunders R, Sutcliffe A et al. Human airway smooth muscle promotes human lung mast cell survival, proliferation, and constitutive activation: cooperative roles for CADM1, stem cell factor, and IL-6. J Immunol 2008;181:27722780.
  • 12
    Thompson EE, Pan L, Ostrovnaya I, Weiss LA, Gern JE, Lemanske RF Jr et al. Integrin beta 3 genotype influences asthma and allergy phenotypes in the first 6 years of life. J Allergy Clin Immunol 2007;119:14231429.
  • 13
    Agis H, Fureder W, Bankl HC, Kundi M, Sperr WR, Willheim M et al. Comparative immunophenotypic analysis of human mast cells, blood basophil and monocytes. Immunology 1996;87:535543.
  • 14
    Columbo M, Bochner BS. Human skin mast cells adhere to vitronectin via the alphavbeta3 integrin receptor (CD51/CD61). J Allergy Clin Immunol 2001;107:554.
  • 15
    Thompson RD, Wakelin MW, Larbi KY, Dewar A, Asimakopoulos G, Horton MA et al. Divergent effects of platelet-endothelial cell adhesion molecule-1 and beta 3 integrin blockade on leukocyte transmigration in vivo. J Immunol 2000;165:426434.
  • 16
    Lackie PM, Baker JE, Gunthert U, Holgate ST. Expression of CD44 isoforms is increased in the airway epithelium of asthmatic subjects. Am J Respir Cell Mol Biol 1997;16:1422.
  • 17
    Katoh S, Matsumoto N, Kawakita K, Tominaga A, Kincade PW, Matsukura S. A role for CD44 in an antigen-induced murine model of pulmonary eosinophilia. J Clin Invest 2003;111:15631570.
  • 18
    Katoh S, Ishii N, Nobumoto A, Takeshita K, Dai SY, Shinonaga R et al. Galectin-9 Inhibits CD44-hyaluronan Interaction and Suppresses a Murine Model of Allergic Asthma. Am J Respir Crit Care Med 2007;176:2735.
  • 19
    Aruffo A, Stamenkovic I, Melnick M, Underhill CB, Seed B. CD44 is the principal cell surface receptor for hyaluronate. Cell 1990;61:13031313.
  • 20
    Mackay CR, Terpe HJ, Stauder R, Marston WL, Stark H, Gunthert U. Expression and modulation of CD44 variant isoforms in humans. J Cell Biol 1994;2:7182.
  • 21
    Lazaar AL, Albelda SM, Pilewski JM, Brennan B, Pure E, Panettieri RA Jr. T lymphocytes adhere to airway smooth muscle cells via integrins and CD44 and induce smooth muscle cell DNA synthesis. J Exp Med 1994; 180:807816.
  • 22
    Ponta H, Sherman L, Herrlich PA. CD44: from adhesion molecules to signalling regulators. Nat Rev Mol Cell Biol 2003;4:3345.
  • 23
    Droll A, Dougherty ST, Chiu RK, Dirks JF, McBride WH, Cooper DL et al. Adhesive interactions between alternatively spliced CD44 isoforms. J Biol Chem 1995;270:1156711573.
  • 24
    Wittig B, Seiter S, Foger N, Schwarzler C, Gunthert U, Zoller M. Functional activity of murine CD44 variant isoforms in allergic and delayed type hypersensitivity. Immunol Lett 1997;3:217223.
  • 25
    Global Strategy for Asthma Management and Prevention, Global Initiative for Asthma (GINA). 2008. Available from:
  • 26
    Trian T, Benard G, Begueret H, Rossignol R, Girodet PO, Ghosh D et al. Bronchial smooth muscle remodeling involves calcium-dependent enhanced mitochondrial biogenesis in asthma. J Exp Med 2007;204: 31733181.
  • 27
    Berger P, Tunon-De-Lara JM, Savineau JP, Marthan R. Selected contribution: tryptase-induced PAR-2-mediated Ca(2+) signaling in human airway smooth muscle cells. J Appl Physiol 2001;91:9951003.
  • 28
    Mark Duffy S, Berger P, Cruse G, Yang W, Bolton SJ, Bradding P. The K+ channel iKCA1 potentiates Ca2+ influx and degranulation in human lung mast cells. J Allergy Clin Immunol 2004;114:6672.
  • 29
    Brightling CE, Kaur D, Berger P, Morgan AJ, Wardlaw AJ, Bradding P. Differential expression of CCR3 and CXCR3 by human lung and bone marrow-derived mast cells: implications for tissue mast cell migration. J Leukoc Biol 2005;77:759766.
  • 30
    Butterfield JH, Weiler D, Dewald G, Gleich GJ. Establishment of an immature mast cell line from a patient with mast cell leukemia. Leuk Res 1988;12:345355.
  • 31
    Trian T, Girodet PO, Ousova O, Marthan R, Tunon-de-Lara JM, Berger P. RNA interference decreases PAR-2 expression and function in human airway smooth muscle cells. Am J Respir Cell Mol Biol 2006;34: 4955.
  • 32
    Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, De Paepe A et al. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 2002;3: research0034.10034.11.
  • 33
    Kruger-Krasagakes S, Grutzkau A, Krasagakis K, Hoffmann S, Henz BM. Adhesion of human mast cells to extracellular matrix provides a co-stimulatory signal for cytokine production. Immunology 1999;98:253257.
  • 34
    Berger P, Compton SJ, Molimard M, Walls AF, N’Guyen C, Marthan R et al. Mast cell tryptase as a mediator of hyperresponsiveness in human isolated bronchi. Clin Exp Allergy 1999;29:804812.
  • 35
    Berger P, Perng DW, Thabrew H, Compton SJ, Cairns JA, McEuen AR et al. Tryptase and agonists of PAR-2 induce the proliferation of human airway smooth muscle cells. J Appl Physiol 2001;91:13721379.
  • 36
    Johnson PR, Roth M, Tamm M, Hughes M, Ge Q, King G et al. Airway smooth muscle cell proliferation is increased in asthma. Am J Respir Crit Care Med 2001;164:474477.
  • 37
    Roth M, Johnson PR, Borger P, Bihl MP, Rudiger JJ, King GG et al. Dysfunctional interaction of C/EBPalpha and the glucocorticoid receptor in asthmatic bronchial smooth-muscle cells. N Engl J Med 2004;351:560574.
  • 38
    Jalkanen S, Jalkanen M. Lymphocyte CD44 binds the COOH-terminal heparin-binding domain of fibronectin. J Cell Biol 1992; 116:817825.
  • 39
    Hynes RO. Integrins: versatility, modulation, and signaling in cell adhesion. Cell 1992;69:1125.
  • 40
    Rothenberg ME. CD44--a sticky target for asthma. J Clin Invest 2003;111:14601462.
  • 41
    Teder P, Vandivier RW, Jiang D, Liang J, Cohn L, Pure E et al. Resolution of lung inflammation by CD44. Science 2002;296: 155158.
  • 42
    Schwarzler C, Oliferenko S, Gunthert U. Variant isoforms of CD44 are required in early thymocyte development. Eur J Immunol 2001;31:29973005.
  • 43
    Wittig BM, Johansson B, Zoller M, Schwarzler C, Gunthert U. Abrogation of experimental colitis correlates with increased apoptosis in mice deficient for CD44 variant exon 7 (CD44v7). J Exp Med 2000;191: 20532064.
  • 44
    Mielgo A, Van Driel M, Bloem A, Landmann L, Gunthert U. A novel antiapoptotic mechanism based on interference of Fas signaling by CD44 variant isoforms. Cell Death Differ 2006;13:465477.