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IgE to peanut allergen components: relation to peanut symptoms and pollen sensitization in 8-year-olds

Authors

  • A. Asarnoj,

    1. National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    2. Department of Paediatrics, Astrid Lindgren’s Children’s Hospital, Stockholm, Sweden
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    • *

      Sharing first authorship.

  • R. Movérare,

    1. Phadia AB, Uppsala, Sweden
    2. Department of Medical Sciences, Respiratory Medicine and Allergology, Uppsala University, Uppsala, Sweden
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      Sharing first authorship.

  • E. Östblom,

    1. Department of Paediatrics, Sachs’ Children’s Hospital, Stockholm, Sweden
    2. Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden
    3. Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden
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  • M. Poorafshar,

    1. Phadia AB, Uppsala, Sweden
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  • G. Lilja,

    1. Department of Paediatrics, Sachs’ Children’s Hospital, Stockholm, Sweden
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  • G. Hedlin,

    1. Department of Paediatrics, Astrid Lindgren’s Children’s Hospital, Stockholm, Sweden
    2. Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden
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  • M. Van Hage,

    1. Department of Medicine, Clinical Immunology and Allergy Unit, Karolinska Institutet and University Hospital, Stockholm, Sweden
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  • S. Ahlstedt,

    1. National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    2. Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden
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  • M. Wickman

    1. National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    2. Department of Paediatrics, Sachs’ Children’s Hospital, Stockholm, Sweden
    3. Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden
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  • Edited by: Bodo Niggemann

Anna Asarnoj, MD, National Institute of Environmental Medicine, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
Tel.: +46 733 200121
Fax: +46 830 4571
E-mail: anna.asarnoj@ki.se

Abstract

To cite this article: Asarnoj A, Movérare R, Östblom E, Poorafshar M, Lilja G, Hedlin G, van Hage M, Ahlstedt S, Wickman M. IgE to peanut allergen components: relation to peanut symptoms and pollen sensitization in 8-year-olds. Allergy 2010; 65: 1189–1195.

Abstract

Background:  Allergen-specific IgE testing is often performed with crude peanut extract, but the results may be difficult to interpret because of cross-reactions between peanut and other plant allergens. The aim was to investigate IgE reactivity to peanut allergen components in children from a birch-rich region in relation to pollen sensitization and peanut symptoms.

Methods:  From a birth cohort, clinical parameters were obtained through questionnaires and IgE antibody levels to peanut and birch pollen were measured. Different peanut/birch sensitization phenotypes were defined among 200 selected children. IgE reactivity to peanut and pollen allergen components was analysed using microarray technique.

Results:  Peanut symptoms were reported in 87% of the children with IgE reactivity to any of the peanut allergens Ara h 1, 2 or 3 but not to Ara h 8 (n = 46) vs 17% of children with IgE reactivity to Ara h 8 but not to Ara h 1, 2 or 3 (n = 23), < 0.001. Furthermore, symptoms were more severe in children with Ara h 1, 2 or 3 reactivity. Children with IgE reactivity both to Ara h 2 and to Ara h 1 or 3 more often reported peanut symptoms than children with IgE only to Ara h 2 (97%vs 70%, = 0.016), particularly respiratory symptoms (50%vs 9%, = 0.002).

Conclusions:  IgE analysis to peanut allergen components may be used to distinguish between peanut-sensitized individuals at risk of severe symptoms and those likely to have milder or no symptoms to peanut if sensitized to pollen allergens and their peanut homologue allergens.

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