Current address: Department of Paediatrics, Ringerike Hospital, Hønefoss, Norway.
Asthma prediction in school children; the value of combined IgE-antibodies and obstructive airways disease severity score*
Article first published online: 5 MAR 2010
© 2010 John Wiley & Sons A/S
Volume 65, Issue 9, pages 1134–1140, September 2010
How to Cite
Lødrup Carlsen, K. C., Söderström, L., Mowinckel, P., Håland, G., Pettersen, M., Munthe Kaas, M. C., Devulapalli, C. S., Buchmann, M., Ahlstedt, S. and Carlsen, K.-H. (2010), Asthma prediction in school children; the value of combined IgE-antibodies and obstructive airways disease severity score. Allergy, 65: 1134–1140. doi: 10.1111/j.1398-9995.2010.02344.x
The study is performed within the ORAACLE (the Oslo Research Group of Asthma and Allergy in Childhood; the Lung and Environment), a member of the GA2LEN (Global Allergy and Asthma European Network).
Edited by: Hans-Uwe Simon
- Issue published online: 4 AUG 2010
- Article first published online: 5 MAR 2010
- Accepted for publication 22 December 2009
- allergic sensitisation;
- immunoglobulin E;
- phadiatop infant;
To cite this article: Lødrup Carlsen KC, Söderström L, Mowinckel P, Håland G, Pettersen M, Munthe Kaas MC, Devulapalli CS, Buchmann M, Ahlstedt S, Carlsen K-H. Asthma prediction in school children; the value of combined IgE-antibodies and obstructive airways disease severity score. Allergy 2010; 65: 1134–1140.
Background: Allergic sensitisation increases the risk for asthma development. In this prospective birth cohort (Environment and Childhood Asthma) study, we hypothesized that combining quantitative measures of IgE antibodies (Σ-IgE) and Severity score of obstructive airways disease (OAD) at 2 years of age (Severity score) is superior to predict current asthma (CA) at 10 years than either measure alone. Secondarily, we assessed if gender modified the prediction of CA.
Methods: A follow-up study at 10 years of age was performed in 371 2-year-old children with recurrent (n = 219) or no (n = 152) bronchial obstruction with available serum analysed for Σ-IgE to common food and inhalant allergens through a panel test, Phadiatop Infant® (Phadia, Uppsala, Sweden). Clinical variables included allergic sensitisation and exercise testing to characterise children with CA vs not CA at 10 years and the Severity score (0–12, 0 indicating no OAD) was used to assess risk modification.
Results: Severity score alone explained 24% (Nagelkerke R2 = 0.24) of the variation in CA, whereas Σ-IgE explained only 6% (R2 = 0.06). Combining the two increased the explanatory capacity to R2 = 0.30. Gender interacted significantly with Σ-IgE; whereas Severity score predicted CA in both genders, the predictive capacity of Σ-IgE for CA at 10 years was significant in boys only.
Conclusion: Combining Σ-IgE to inhalant allergens and Severity score at 2 years was superior to predict asthma at 10 years than either alone. Severity score predicted CA in both genders, whereas Σ-IgE significantly predicted CA in boys only.