Edited by: Hans-Uwe Simon
Cyclosporine-A in severe chronic urticaria: the option for long-term therapy
Article first published online: 7 JUL 2010
© 2010 John Wiley & Sons A/S
Volume 65, Issue 11, pages 1478–1482, November 2010
How to Cite
Kessel, A. and Toubi, E. (2010), Cyclosporine-A in severe chronic urticaria: the option for long-term therapy. Allergy, 65: 1478–1482. doi: 10.1111/j.1398-9995.2010.02419.x
- Issue published online: 7 JUL 2010
- Article first published online: 7 JUL 2010
- Accepted for publication 23 April 2010
- chronic urticaria;
To cite this article: Kessel A, Toubi E. Cyclosporine-A in severe chronic urticaria: the option for long-term therapy. Allergy 2010; 65: 1478–1482.
Background: The treatment of severe chronic urticaria (CU) remains a difficult goal to achieve. Many patients do not respond to anti-histamine therapy, even when off-label doses are given. Thus, cyclosporine-A (CsA) becomes a good therapeutic option for severe patients and for some, long-term therapy is required. We evaluated the effectiveness and safety of low-dose CsA, when treatment cannot be discontinued and long-term CsA therapy is needed to maintain severe CU in remission.
Methods: Among 2000 patients with CU who were referred to our outpatient clinic, 120 patients who suffered from a very severe CU began treatment with CsA 3 mg/kg. A clinical and laboratory followup was performed during this period of treatment.
Results: In 20 patients, CsA was discontinued within 2–15 days after initiation because of side-effects. Among 62 of the remaining 100 patients (62%), CsA was administered for a period of 3 months with a highly beneficial outcome. In another 20 patients (20%), CsA was considered beneficial; however, it was required for a longer period of time, 5–10 years for some of the cases. In all cases, CsA was well tolerated and most important, it was safe. For 18 patients (18%), CsA therapy was reported as failed.
Conclusion: A low dose of CsA is a good option for patients who suffer from especially severe CU. In most cases, this therapy regimen is considered effective and safe. For a small group of patients, long-term therapy is needed, and until now it is considered safe.