The I/D polymorphism of angiotensin-converting enzyme gene and asthma risk: a meta-analysis

Authors


  • Edited by: Stephen Weidinger

Prof. Hong Fan, MD, PhD, Department of Respiratory Medicine, West China Hospital of Sichuan University, Guoxuexiang 37, Chengdu, Sichuan 610041 China.
Tel.: 86 28 85423520
Fax: 86 28 85423520
E-mail: fanhongfan@yahoo.com

Abstract

To cite this article: Zhang Y-G, Li X-B, Zhang J, Huang J, He C, Tian C, Deng Y, Wan H, Shrestha D, Yang Y-Y, Fan H. The I/D polymorphism of angiotensin-converting enzyme gene and asthma risk: a meta-analysis. Allergy 2011; 66: 197–205.

Abstract

Background:  The insertion/deletion (I/D) polymorphism of angiotensin-converting enzyme (ACE) gene has been implicated in susceptibility to asthma, but a large number of studies have reported inconclusive results. The aim of this study is to investigate the association between the I/D polymorphism of ACE gene and asthma risk by meta-analysis.

Methods:  We searched Medline (Ovid), Pubmed, CNKI, Wanfang, and Weipu database, covering all papers until March 12, 2010. Statistical analysis was performed by using the software revman 4.2 (The Cochrane Collaboration, http://www.cochrane.org) and stata 10.0 (StataCorp, College Station, TX, USA, http://www.stata.com).

Results:  A total of 1946 cases and 2152 controls in 18 case–control studies were included in this meta-analysis. The results indicated that the DD homozygote carriers had a 59% increased risk of asthma, when compared with the homozygotes II and heterozygote DI [odds ratio (OR) = 1.59, 95% confidence interval (CI): 1.16–2.18]. In the subgroup analysis by ethnicity, significant elevated risks were associated with DD homozygote carriers in Asians (OR = 2.02 and 95% CI: 1.29–3.16 for DD vs DI+II) but not in Caucasians (OR = 1.14 and 95% CI: 0.76–1.72 for DD vs DI+II). In the subgroup analysis by age, significant elevated risks were associated with DD homozygote carriers in children (OR = 2.44 and 95% CI: 1.36–4.38 for DD vs II+DI) but not in adults (OR = 1.54 and 95% CI: 0.94–2.51 for DD vs II+DI).

Conclusions:  This meta-analysis suggested that the I/D polymorphism of ACE gene would be a risk factor of asthma. To further evaluate gene-to-gene and gene-to-environment interactions between polymorphisms of ACE gene and asthma risk, more studies with large groups of patients are required.

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