Edited by: Hans-Uwe Simon
Fatty acids in breast milk and development of atopic eczema and allergic sensitisation in infancy
Article first published online: 23 JUL 2010
© 2010 John Wiley & Sons A/S
Volume 66, Issue 1, pages 58–67, January 2011
How to Cite
Thijs, C., Müller, A., Rist, L., Kummeling, I., Snijders, B. E. P., Huber, M., Van Ree, R., Simões-Wüst, A. P., Dagnelie, P. C. and Van Den Brandt, P. A. (2011), Fatty acids in breast milk and development of atopic eczema and allergic sensitisation in infancy. Allergy, 66: 58–67. doi: 10.1111/j.1398-9995.2010.02445.x
- Issue published online: 3 DEC 2010
- Article first published online: 23 JUL 2010
- Accepted for publication 14 June 2010
- human milk;
- omega-3 fatty acids;
- organic dairy;
- ruminant fatty acids
To cite this article: Thijs C, Müller A, Rist L, Kummeling I, Snijders BEP, Huber M, van Ree R, Simões-Wüst AP, Dagnelie PC, van den Brandt PA. Fatty acids in breast milk and development of atopic eczema and allergic sensitisation in infancy. Allergy 2011; 66: 58–67.
Background: One of the explanations for the increasing prevalence of atopic diseases is a relative low perinatal supply of n-3 fatty acids. However, this does not explain the protective effects of whole-fat dairy products or high levels of transfatty acids in breast milk, observed in some studies. We evaluated the role of perinatal supply of fatty acids in the early development of atopic eczema and allergic sensitisation.
Methods: Fatty acids, including n-3 long-chain polyunsaturated fatty acids (LCPs) as well as ruminant fatty acids (rumenic acid, cis-9,trans-11-C18:2 conjugated linoleic acid; and vaccenic acid, trans-11-C18:1), were determined in breast milk sampled at 1 month postpartum from 310 mother–infant pairs in the KOALA Birth Cohort Study, the Netherlands. Children were followed for atopic outcomes until 2 years of age.
Results: Higher concentrations of n-3 LCPs as well as ruminant fatty acids were associated with lower risk of (1) parent-reported eczema, (2) atopic dermatitis (UK Working Party criteria), and (3) sensitisation at age 1 year (as revealed by specific serum IgE levels to cow’s milk, hen’s egg and/or peanut). In multivariable logistic regression analysis, the inverse associations between ruminant fatty acid concentrations in breast milk and atopic outcomes were found to be independent from n-3 LCPs.
Conclusions: The results confirm a protective role of preformed n-3 LCPs in the development of atopic disease. Moreover, this is the first study in humans confirming results from animal studies of protective effects of ruminant fatty acids against the development of atopic manifestations.