Professor Nikolaos Papadopoulos has received the Phadia Allergy Research Forum (PhARF) Award 2010 for his work on viruses and asthma.
Viruses and bacteria in acute asthma exacerbations – A GA2LEN-DARE systematic review*
Article first published online: 18 NOV 2010
© 2010 John Wiley & Sons A/S
Volume 66, Issue 4, pages 458–468, April 2011
How to Cite
Papadopoulos, N. G., Christodoulou, I., Rohde, G., Agache, I., Almqvist, C., Bruno, A., Bonini, S., Bont, L., Bossios, A., Bousquet, J., Braido, F., Brusselle, G., Canonica, G. W., Carlsen, K. H., Chanez, P., Fokkens, W. J., Garcia-Garcia, M., Gjomarkaj, M., Haahtela, T., Holgate, S. T., Johnston, S. L., Konstantinou, G., Kowalski, M., Lewandowska-Polak, A., Lødrup-Carlsen, K., Mäkelä, M., Malkusova, I., Mullol, J., Nieto, A., Eller, E., Ozdemir, C., Panzner, P., Popov, T., Psarras, S., Roumpedaki, E., Rukhadze, M., Stipic-Markovic, A., Todo Bom, A., Toskala, E., van Cauwenberge, P., van Drunen, C., Watelet, J. B., Xatzipsalti, M., Xepapadaki, P. and Zuberbier, T. (2011), Viruses and bacteria in acute asthma exacerbations – A GA2LEN-DARE systematic review. Allergy, 66: 458–468. doi: 10.1111/j.1398-9995.2010.02505.x
GA2LEN: Global Asthma and Allergy European Network DARE: Definition And Risk factors of Exacerbations working group.
Edited by: Hans-Uwe Simon
- Issue published online: 24 FEB 2011
- Article first published online: 18 NOV 2010
- Accepted for publication 13 October 2010
- asthma exacerbation;
- atypical bacteria;
- detection method;
- respiratory virus
To cite this article: Papadopoulos NG, Christodoulou I, Rohde G, Agache I, Almqvist C, Bruno A, Bonini S, Bont L, Bossios A, Bousquet J, Braido F, Brusselle G, Canonica GW, Carlsen KH, Chanez P, Fokkens WJ, Garcia-Garcia M, Gjomarkaj M, Haahtela T, Holgate ST, Johnston SL, Konstantinou G, Kowalski M, Lewandowska-Polak A, Lødrup-Carlsen K, Mäkelä M, Malkusova I, Mullol J, Nieto A, Eller E, Ozdemir C, Panzner P, Popov T, Psarras S, Roumpedaki E, Rukhadze M, Stipic-Markovic A, Todo Bom A, Toskala E, van Cauwenberge P, van Drunen C, Watelet JB, Xatzipsalti M, Xepapadaki P, Zuberbier T. Viruses and bacteria in acute asthma exacerbations – A GA2LEN-DARE systematic review. Allergy 2011; 66: 458–468.
A major part of the burden of asthma is caused by acute exacerbations. Exacerbations have been strongly and consistently associated with respiratory infections. Respiratory viruses and bacteria are therefore possible treatment targets. To have a reasonable estimate of the burden of disease induced by such infectious agents on asthmatic patients, it is necessary to understand their nature and be able to identify them in clinical samples by employing accurate and sensitive methodologies. This systematic review summarizes current knowledge and developments in infection epidemiology of acute asthma in children and adults, describing the known impact for each individual agent and highlighting knowledge gaps. Among infectious agents, human rhinoviruses are the most prevalent in regard to asthma exacerbations. The newly identified type-C rhinoviruses may prove to be particularly relevant. Respiratory syncytial virus and metapneumovirus are important in infants, while influenza viruses seem to induce severe exacerbations mostly in adults. Other agents are relatively less or not clearly associated. Mycoplasma and Chlamydophila pneumoniae seem to be involved more with asthma persistence rather than with disease exacerbations. Recent data suggest that common bacteria may also be involved, but this should be confirmed. Although current information is considerable, improvements in detection methodologies, as well as the wide variation in respect to location, time and populations, underline the need for additional studies that should also take into account interacting factors.