Edited by: Stephan Weidinger
Relationship between type 1 diabetes and atopic diseases in a twin population
Version of Record online: 1 DEC 2010
© 2010 John Wiley & Sons A/S
Volume 66, Issue 5, pages 645–647, May 2011
How to Cite
Thomsen, S. F., Duffy, D. L., Kyvik, K. O., Skytthe, A. and Backer, V. (2011), Relationship between type 1 diabetes and atopic diseases in a twin population. Allergy, 66: 645–647. doi: 10.1111/j.1398-9995.2010.02517.x
- Issue online: 7 APR 2011
- Version of Record online: 1 DEC 2010
- Accepted for publication 2 November 2010
- Atopic dermatitis;
- twin study;
- type 1 diabetes
To cite this article: Thomsen SF, Duffy DL, Kyvik KO, Skytthe A, Backer V. Relationship between type 1 diabetes and atopic diseases in a twin population. Allergy 2011; 66: 645–647.
Aim: To study the association between type 1 diabetes and atopic diseases in a twin population.
Methods: We performed record linkage between questionnaire-defined atopic dermatitis, asthma and hay fever, and hospital discharge diagnoses of type 1 diabetes in 54 530 Danish twins, 3–71 years of age.
Results: The age- and sex-adjusted risk of atopic dermatitis was decreased in subjects with type 1 diabetes compared with nondiabetic subjects, (2.1%vs 9.9%), odds ratio (OR) = 0.23 (0.07–0.71), P = 0.011, whereas asthma and hay fever were not significantly associated with type 1 diabetes. Within twin pairs discordant for type 1 diabetes, the diabetic twin had a lower risk of atopic dermatitis relative to the nondiabetic co-twin. Genetic factors for atopic dermatitis and type 1 diabetes were negatively correlated (r = −0.30), P = 0.0009.
Conclusions: These findings substantiate the Th1 vs Th2 cell dichotomy for type 1 diabetes and atopic dermatitis, and indicate an inverse association between genetic factors for these disorders.