for the ENDA – European Network of Drug Allergy/EAACI Interest Group on Drug Hypersensitivity.
Article first published online: 14 FEB 2011
© 2011 John Wiley & Sons A/S
Volume 66, Issue 7, pages 818–829, July 2011
How to Cite
Kowalski, M. L., Makowska, J. S., Blanca, M., Bavbek, S., Bochenek, G., Bousquet, J., Bousquet, P., Celik, G., Demoly, P., Gomes, E. R., Niżankowska-Mogilnicka, E., Romano, A., Sanchez-Borges, M., Sanz, M., Torres, M. J., De Weck, A., Szczeklik, A. and Brockow, K. (2011), Hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) – classification, diagnosis and management: review of the EAACI/ENDA and GA2LEN/HANNA. Allergy, 66: 818–829. doi: 10.1111/j.1398-9995.2011.02557.x
Edited by: Hans-Uwe Simon
- Issue published online: 1 JUN 2011
- Article first published online: 14 FEB 2011
- Accepted for publication 17 January 2011
- aspirin hypersensitivity;
- drug allergy;
- nonsteroidal anti-inflammatory drugs
To cite this article: Kowalski ML, Makowska JS, Blanca M, Bavbek S, Bochenek G, Bousquet J, Bousquet P, Celik G, Demoly P, Gomes ER, Niżankowska-Mogilnicka E, Romano A, Sanchez-Borges M, Sanz M, Torres MJ, De Weck A, Szczeklik A, Brockow K. Hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) – classification, diagnosis and management: Review of the EAACI/ENDA and GA2LEN/HANNA. Allergy 2011; 66: 818–829.
Nonsteroidal anti-inflammatory drugs (NSAIDs) are responsible for 21–25% of reported adverse drug events which include immunological and nonimmunological hypersensitivity reactions. This study presents up-to-date information on pathomechanisms, clinical spectrum, diagnostic tools and management of hypersensitivity reactions to NSAIDs. Clinically, NSAID hypersensitivity is particularly manifested by bronchial asthma, rhinosinusitis, anaphylaxis or urticaria and variety of late cutaneous and organ-specific reactions. Diagnosis of hypersensitivity to a NSAID includes understanding of the underlying mechanism and is necessary for prevention and management. A stepwise approach to the diagnosis of hypersensitivity to NSAIDs is proposed, including clinical history, in vitro testing and/or provocation test with a culprit or alternative drug depending on the type of the reaction. The diagnostic process should result in providing the patient with written information both on forbidden and on alternative drugs.