The future of specific immunotherapy: strategies and challenges for the next generation of allergy vaccines
Article first published online: 13 JUN 2011
© 2011 John Wiley & Sons A/S
Special Issue: The 8th Symposium on Specific Allergy (SOSA) 2010.
Volume 66, Issue Supplement s95, pages 63–65, July 2011
How to Cite
Sørensen, P. (2011), The future of specific immunotherapy: strategies and challenges for the next generation of allergy vaccines. Allergy, 66: 63–65. doi: 10.1111/j.1398-9995.2011.02644.x
- Issue published online: 13 JUN 2011
- Article first published online: 13 JUN 2011
- Accepted for publication 15 March 2011
- Biomarker research;
- evidence-based medicine;
- future immunotherapy;
- personalised medicine;
- primary prevention
To cite this article: Sørensen P. The future of specific immunotherapy: strategies and challenges for the next generation of allergy vaccines. Allergy 2011; 66 (Suppl. 95): 63–65.
The use of specific immunotherapy (SIT) for allergic disorders has recently been extended by introduction of a convenient, tablet-based, disease-modifying vaccine against grass pollen allergy. Allergy immunotherapy tablet (AIT) programmes targeting house dust mite and other allergies are currently in late-phase development. Next-generation allergy vaccines can have optimised potency and onset of action without compromising safety or convenience. Key to achieving these objectives is a combination of evidence-based mode-of-action studies and biomarker-centric translational research approaches. This will rely on using biobank and bioinformatics resources for multi-omic characterisations of the ‘immunome’ of allergic disease. Other important areas are ongoing paediatric trials and long-term studies in adults for further defining the potential role of SIT in allergic disease and primary prevention of asthma. Finally, combining cellular- and serological-based assays, and developments in targeted delivery platforms and component-resolved diagnostics will lead to increased ability to stratify patients, with more personalised diagnosis and treatment.