Edited by: Pascal Demoly
The in vitro diagnosis of drug allergy: status and perspectives
Article first published online: 7 JUN 2011
© 2011 John Wiley & Sons A/S
Volume 66, Issue 10, pages 1275–1286, October 2011
How to Cite
Ebo, D. G., Leysen, J., Mayorga, C., Rozieres, A., Knol, E. F. and Terreehorst, I. (2011), The in vitro diagnosis of drug allergy: status and perspectives. Allergy, 66: 1275–1286. doi: 10.1111/j.1398-9995.2011.02661.x
- Issue published online: 9 SEP 2011
- Article first published online: 7 JUN 2011
- Accepted for publication 11 May 2011
- basophil activation test;
- drug allergy;
- lymphocyte transformation test
To cite this article: Ebo DG, Leysen J, Mayorga C, Rozieres A, Knol EF, Terreehorst I. The in vitro diagnosis of drug allergy: status and perspectives. Allergy 2011; 66: 1275–1286.
Adverse drug reactions (ADR) can result from immune-mediated (drug allergy) and nonimmune-mediated mechanisms. In both types of reaction, conclusive diagnosis and appropriate management remain major problems in daily clinical practice. This review summarizes the potentials and shortcomings of the currently available in vitro tests in the diagnosis of immediate (mostly IgE mediated) and nonimmediate (mostly T-cell mediated) drug allergy, particularly quantification of specific IgE, flow-assisted analysis of in vitro activated lymphocytes and basophils and the enzyme-linked immunosorbent spot.