Edited by: Hans-Uwe Simon
Asthma, allergy and respiratory infections: the vitamin D hypothesis
Article first published online: 21 SEP 2011
© 2011 John Wiley & Sons A/S
Volume 67, Issue 1, pages 10–17, January 2012
How to Cite
Bozzetto, S., Carraro, S., Giordano, G., Boner, A. and Baraldi, E. (2012), Asthma, allergy and respiratory infections: the vitamin D hypothesis. Allergy, 67: 10–17. doi: 10.1111/j.1398-9995.2011.02711.x
- Issue published online: 12 DEC 2011
- Article first published online: 21 SEP 2011
- Accepted for publication 15 August 2011
- respiratory infection;
- vitamin D
To cite this article: Bozzetto S, Carraro S, Giordano G, Boner A, Baraldi E. Asthma, allergy, and respiratory infections: the vitamin D hypothesis. Allergy 2012; 67: 10–17.
The recent discovery that every tissue in the human body has vitamin D receptors and that vitamin D has pleiotropic effects has prompted an increased interest in this hormone. Vitamin D deficiency is widespread and on the increase. There is no consensus on the serum vitamin D levels to consider appropriate for global health, the cutoffs for its deficiency, or the doses to use for its supplementation. Vitamin D seems to correlate closely with host reactions against various respiratory infections. Epidemiological studies have shown that low serum 25-hydroxyvitamin D levels are associated with a higher risk of upper and lower respiratory infections in children and a shortage of vitamin D may contribute to asthmatic patients’ symptoms and morbidity rates. There are studies highlighting associations between childhood asthma, fetal lung and/or immune development, and maternal vitamin D intake. An insufficiency of this vitamin also seems to be implicated in the onset of childhood atopy and food allergies. The hypothesis is that vitamin D could have a central role in these pathological situations and that it may represent a novel preventive and/or therapeutic strategy. This article reviews and discusses published data on the relationship between vitamin D and asthma and allergy, emphasizing the need for controlled, prospective studies on vitamin D supplementation to clarify whether it has a role in the prevention of and treatment for asthma and allergic conditions.