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Figure S1. Flow chart of data availability in the PIAMA intervention study.

Figure S2. Adjusted1 age-specific and overall associations between the intervention (active covers vs natural history high risk group) and asthma, hay fever and related symptoms during the first 8 years of life (1Adjusted for all variables from Table 1 that were statistically significantly (< 0.05) different between active cover group and placebo group or natural history high risk group and placebo group, respectively, i.e. mother asthma, mother allergic to house dust mite, gender, and presence of pets. Associations are presented as relative risks with 95% confidence intervals).

Figure S3. Adjusted1 age-specific and overall associations between Der p1 levels at the age of 3 month and asthma, hay fever and related symptoms during the first 8 years of life (1Adjusted for all variables from Table 1 that were statistically significantly (< 0.05) different between active cover group and placebo group or natural history high risk group and placebo group, respectively, i.e. mother asthma, mother allergic to house dust mite, gender, and pets at home. Associations are presented as relative risks with 95% confidence intervals).

Figure S4. Adjusted1 age-specific and overall associations between Der f1 levels at the age of 3 month and asthma, hay fever and related symptoms during the first 8 years of life (1Adjusted for all variables from Table 1 that were statistically significantly (< 0.05) different between active cover group and placebo group or natural history high risk group and placebo group, respectively, i.e. mother asthma, mother allergic to house dust mite, gender, and pets at home. Associations are presented as relative risks with 95% confidence intervals).

Table S1. House dust mite allergen levels in the child’s mattress dust at age 8 years for the three study groups expressed as geometric means (GM) with geometric standard deviations (GSD), and geometric means ratios (GMR) with 95% confidence intervals (CI) for all participants.

Table S2. Adjusted1 associations2 between the intervention and asthma-related health outcomes at age 8 years by allergic sensitization at ages 1 and 8 years (1Adjusted for all variables from Table 1 that were significantly (< 0.05) different between active cover group and placebo group or natural history high risk group and placebo group, respectively, i.e. mother asthma, mother allergic to house dust mite, gender, pets at home. 2Associations are presented as relative risks (RR) with 95% confidence intervals (CI)).

Table S3. Distribution of house dust mite allergen levels in house dust samples collected on the child’s mattress at age 3 months.

Table S4. Adjusted1 associations2 between house dust mite allergen levels (Der p1+Der f1) per gram of mattress dust collected at age 3 months and health outcomes at age 8 years in participants of the intervention study and high-risk participants of the natural history study. Children with non-detectable allergen levels served as reference category (1Adjusted for all variables from Table 1 that were statistically significantly (< 0.05) different between active cover group and placebo group or natural history high risk group and placebo group, respectively, i.e. mother asthma, mother allergic to house dust mite, pets in the home. 2Associations are presented as relative risks (RR) with 95% confidence intervals (CI)).

Table S5. Adjusted1 associations2 between levels of house dust mite allergens Der p1 and Der f1 per gram of mattress dust collected at age 3 months and health outcomes at age 8 years in participants of the intervention study and high-risk participants of the natural history study. Children with non-detectable allergen levels served as reference category (1Adjusted for all variables from Table 1 that were statistically significantly (< 0.05) different between active cover group and placebo group or natural history high risk group and placebo group, respectively, i.e. mother asthma, mother allergic to house dust mite, pets in the home. 2Associations are presented as relative risks (RR) with 95% confidence intervals (CI)).

Data S1. Supplementary material.

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all_2739_sm_SupplementaryMaterial.doc155KSupporting info item

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