Edited by: Thomas Bieber
House dust mite avoidance measures for perennial allergic rhinitis: an updated Cochrane systematic review
Version of Record online: 22 NOV 2011
© 2011 John Wiley & Sons A/S
Volume 67, Issue 2, pages 158–165, February 2012
How to Cite
Nurmatov, U., van Schayck, C. P., Hurwitz, B. and Sheikh, A. (2012), House dust mite avoidance measures for perennial allergic rhinitis: an updated Cochrane systematic review. Allergy, 67: 158–165. doi: 10.1111/j.1398-9995.2011.02752.x
- Issue online: 11 JAN 2012
- Version of Record online: 22 NOV 2011
- Accepted for publication 23 October 2011
- avoidance measures;
- house dust mite;
- perennial allergic rhinitis
To cite this article: Nurmatov U, van Schayck CP, Hurwitz B, Sheikh A. House dust mite avoidance measures for perennial allergic rhinitis: an updated Cochrane systematic review. Allergy 2012; 67: 158–165.
Background: To assess the benefits and harms of measures designed to reduce house dust mite (HDM) exposure in the management of house dust mite–sensitive allergic rhinitis.
Methods: Systematic review of randomized controlled trials was made, in which HDM control measures have been evaluated in comparison with placebo or other HDM avoidance measures, in patients with clinically proven allergic rhinitis.
Results: Nine trials involving 501 participants satisfied the inclusion criteria. These trials have investigated the effectiveness of bedroom environmental control programmes involving the use of HDM impermeable bedding covers (n = 4), acaricides (n = 2), high-efficiency particulate air filters (n = 2) and, using a factorial design, acaricide and HDM impermeable bedding covers in isolation and combination (n = 1). Seven of the nine trials reported that, when compared with control, the interventions studied resulted in significant reductions in HDM load. Of the interventions studied to date, acaricides appear to be the most promising, although the findings from these studies need to be interpreted with care because of their methodological limitations. House dust mite impermeable bedding as an isolated intervention is unlikely to offer benefit.
Conclusions: Trials have tended to be small and of poor methodological quality, making it difficult to offer any definitive recommendations. Interventions that achieve substantial reductions in HDM load may offer some benefit in reducing rhinitis symptoms. Isolated use of HDM impermeable bedding is unlikely to prove effective.