The role of vitamin D in the immunopathogenesis of allergic skin diseases

Authors


  • Edited by: Hans-Uwe Simon

Sunit P. Jariwala, Division of Allergy/Immunology, Montefiore Medical Center, Albert Einstein College of Medicine, 111 East 210th Street, Bronx, NY 10463, USA.
Tel.: +718 920 4321
Fax: +718 405 8074
E-mail: sjariwal@montefiore.org

Abstract

To cite this article: Benson AA, Toh JA, Vernon N, Jariwala SP. The role of vitamin D in the immunopathogenesis of allergic skin diseases. Allergy 2012; 67: 296–301.

Abstract

Vitamin D plays key roles in innate and adaptive immunity through the stimulation of Toll-like receptors, increasing pro-inflammatory cytokine production, and possibly enhancing T helper type 2 responses. These mechanisms may explain the growing body of evidence connecting vitamin D to allergic diseases, including asthma, food allergies, and allergic rhinitis. The data relating vitamin D to allergic skin diseases are equivocal with studies linking both high and low vitamin D levels to an increased risk of developing atopic dermatitis. In this paper, we describe the role of vitamin D in the immunopathogenesis of atopic dermatitis and other allergic skin diseases.

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