• 1
    Dworski R. Oxidant stress and asthma. Thorax 2000;55:S51S53.
  • 2
    Dworski R, Murray JJ, Roberts LJ, II, Oates JA, Morrow JD et al. Allergen-induced synthesis of F2-isoprostanes in atopic asthmatics. Evidence for oxidative stress. Am J Respir Crit Care Med 1999;160:19471951.
  • 3
    Roberts LJ, Morrow JD. Measurement of F2-isoprostanes as an index of oxidative stress in vivo. Free Radic Biol Med 2000;28:505513.
  • 4
    Patel S, Murray CS, Woodcock A, Simpson A, Custovic A. Dietary antioxidant intake, allergic sensitization and allergic diseases in young children. Allergy 2009;64:17661772.
  • 5
    Wood LG, Gibson PG. Reduced circulating antioxidant defenses are associated with airway hyperresponsiveness, poor control and severe disease pattern in asthma. Br J Nutr 2010;103:735741.
  • 6
    Talati M, Meyrick B, Peebles RS Jr, Davies SS, Dworski R, Mernaugh R et al. Oxidant stress modulates murine allergic airway responses. Free Radic Biol Med 2006;40:12101219.
  • 7
    Traber MG, Atkinson J. Vitamin E, antioxidant and nothing more. Free Radical Biol Med 2007;43:415.
  • 8
    Berdnikovs S, Abdala-Valencia H, McCary C, Somand M, Cole R, Garcia A et al. Isoforms of vitamin E have opposing immunoregulatory functions during inflammation by regulating leukocyte recruitment. J Immunol 2009;182:43954405.
  • 9
    McCary CA, Abdala-Valencia H, Berdnikovs S, Cook-Mills JM. Supplemental and highly elevated tocopherol doses differentially regulate allergic inflammation: reversibility of α-tocopherol and γ-tocopherol's effects. J Immunol 2011;186:36743685.
  • 10
    Pearson PJK, Lewis SA, Britton J, Fogarty A. Vitamin E supplements in asthma: a parallel group randomized placebo controlled trial. Thorax 2004;59:652656.
  • 11
    Roberts LJ, II, Oates JA, Linton MF, Fazio S, Meador BP et al. The relationship between dose of vitamin E and suppression of oxidative stress in humans. Free Radical Biol Med 2007;43:13881393.
  • 12
    National Asthma Education and Prevention Program. Experts Panel Rapport 3: Guidelines for the Diagnosis and Management of Asthma. Bethesda, MD: National Institute of Health, National Heart, Lung, and Blood Institute, 2007. Pub no. 08-5846.
  • 13
    American College of Allergy, Asthma and Immunology, American Academy of Allergy, Asthma and Immunology, and the Joint Council of Allergy, Asthma and Immunology. Practice Parameters for Allergy Diagnostic Testing. Ann Allergy Asthma Immunol 1995;75:543625.
  • 14
    American Thoracic Society. Guidelines for methacholine and exercise challenge testing. Am J Respir Crit Care Med 2000;161:309329.
  • 15
    Cockcroft DW, Davis BE, Boulet L-P, Deschesnes F, Gauvreau GM, O'Byrne P et al. The links between allergen skin test sensitivity, airway responsiveness and airway response to allergen. Allergy 2005;60:5659.
  • 16
    Dworski R, Simons HU, Hoskins A, Yousefi S. Eosinophil and neutrophil extracellular DNA traps in human allergic asthmatic airways. J Allergy Clin Immunol 2011;127:12601266.
  • 17
    Gross MD, Yu X, Hannan P, Prouty C, Jacobs Dr Jr. Lipid standardization of serum fat-soluble antioxidant concentrations; the YALTA study. Am J Clin Nutr 2003;77:458466.
  • 18
    Handelman GJ, Machlin LJ, Fitch K, Weiter JJ, Dratz EA. Oral alpha-tocopherol supplements decrease plasma gamma-tocopherol levels in humans. J Nutr 1985;115:807813.
  • 19
    Boot JD, de Haas S, Tarasevych S, Roy C, Wang L, Amin D et al. Effect of an NK1/NK2 receptor antagonist on airway responses and inflammation to allergen in asthma. Am J Respir Crit Care Med 2007;175:450457.
  • 20
    Boulet LP, Turcotte H, Laviolette M, Côté J, Wyile G, Bologa M. Inhibitory effects of BAY x 7195, a CYS leukotriene 1 receptor antagonist, on allergen-induced asthmatic responses. Ann Allergy Asthma Immunol 1997;79:155161.
  • 21
    Juniper EF, Buist AS, Cox FM, Ferrie PJ, King DR. Validation of a standardized version of the Asthma Quality of Life Questionnaire. Chest 1999;115:12651270.
  • 22
    Virchow JC Jr, Walker C, Hafner D, Kortsik C, Werner P, Matthys H et al. T cell and cytokines in bronchoalveolar lavage fluid after segmental allergen provocation in atopic asthma. Am J Respir Crit Care Med 1995;151:960968.
  • 23
    Krug NJ, Madden AE, Redington P, Lackie P, Djukanovic R, Schauer U et al. T cell cytokine profile evaluated at the single cell level in BAL and blood in allergic asthma. Am J Respir Crit Care Med 1996;14:319326.
  • 24
    Wilson DR, Merrett TG, Varga EM, Smurthwaite L, Gould HJ, Kemp M et al. Increases in allergen-specific IgE in BAL after segmental allergen challenge in atopic asthmatics. Am J Respir Crit Care Med 2002;165:2226.
  • 25
    Peterson JD, Herzenberg LA, Vasquez K, Waltenbaugh C. Glutathione levels in antigen-presenting cells modulate Th1 versus Th2 response patterns. Proc Natl Acad Sci USA 1998;95:30713076.
  • 26
    Jackson SH, Devadas S, Kwon J, Pinto LA, Williams MS. T cells express a phagocyte-type NADPH oxidase that is activated after T cell receptor stimulation. Nat Immunol 2004;5:818827.
  • 27
    Sly LM, Kalesnikoff J, Lam V, Wong D, Song C, Omeis S et al. IgE-induced mast cell survival requires the prolonged generation of reactive oxygen species. J Immunol 2008;181:38503860.
  • 28
    Woodruff PG, Modrek B, Choy DF, Jia G, Abbas AR, Ellwanger A et al. T-helper type 2-driven inflammation defines major subphenotypes of asthma. Am J Respir Crit Care Med 2009;180:388395.
  • 29
    Tang H, Cao W, Kasturi SP, Rawindran R, Nakaya HI, Kundu K et al. The T helper type 2 response to cysteine proteases requires dendritic cell-basophil cooperation via ROS-mediated signaling. Nat Immunol 2010;11:608617.
  • 30
    Spiteri MA, Bianco A, Strange SC, Fryer AA. Polymorphisms at the glutathione S-transferase, GSTP1 locus: a novel mechanism for susceptibility and development of atopic airway inflammation. Allergy 2000;55:1520.
  • 31
    Reddy PH. Mitochondrial dysfunction and oxidative stress in asthma: implications for mitochondria-targeted antioxidant therapeutics. Pharmaceuticals 2011;4:429456.
  • 32
    Dworski R, Han W, Blackwell TS, Hoskins A, Freeman ML. Vitamin E prevents NRF2 suppression by allergens in asthmatic alveolar macrophages in vivo. Free Radic Biol Med 2011;51:516521.
  • 33
    Glynn RJ, Ridker PM, Goldhaber SZ, Zee RYL, Buring JE. Effect of random allocation to vitamin E supplementation on the occurrence of venous thromboembolism. Report from the Womans' Health Study. Circulation 2007;116:14971503.
  • 34
    Slatore CG, Littman AJ, Au DH, Satia JA, White E. Long-term use of supplemental vitamins, vitamin C, vitamin E, and folate does not reduce the risk of lung cancer. Am J Respir Crit Care Med 2008;177:524530.
  • 35
    Klein EA, Thompson IM Jr, Tangen CM, Crowley JJ, Lucia MS et al. Vitamin E and the risk of prostate cancer. The selenium and vitamin E cancer prevention trial (SELECT). JAMA 2011;306:15491556.
  • 36
    Agler AH, Kurth T, Gaziano JM, Buring JE, Cassano PA. Randomised vitamin E supplementation and risk of chronic lung disease in the Women's Health Study. Thorax 2011;66:320325.