Edited by: Hans-Uwe Simon
Transforming growth factor-beta1 in inflammatory airway disease: a key for understanding inflammation and remodeling
Article first published online: 23 AUG 2012
© 2012 John Wiley & Sons A/S
Volume 67, Issue 10, pages 1193–1202, October 2012
How to Cite
To cite this article: Transforming growth factor-beta1 in inflammatory airway disease: a key for understanding inflammation and remodeling. Allergy2012 67: 1193–1202., , , , , .
- Issue published online: 13 SEP 2012
- Article first published online: 23 AUG 2012
- Manuscript Accepted: 27 JUN 2012
- Fund for Scientific Research Flanders. Grant Numbers: 3G.0489. 08, G.0642.10N
- Interuniversity Attraction Poles program (IUAP)
- airway disease;
- transforming growth factor-beta
Airway diseases such as chronic rhinosinusitis, asthma, and chronic obstructive pulmonary disorder are characterized by inflammation and remodeling. Among inflammatory and extracellular matrix regulatory cytokines, transforming growth factor-beta (TGF-β) stands central, as it possesses both important immunomodulatory and fibrogenic activities, and should be considered a key for understanding inflammation and remodeling processes. This review will briefly summarize the recent findings on the role of TGF-β1, from the view points of inflammation and remodeling, and discuss the role of TGF-β in the upper and lower airway diseases. This may reveal new perspectives in the understanding of airway inflammation and remodeling processes and may open innovative treatment strategies for the regulation of TGF-β1.