Lp(a) lipoprotein and pre-β1-lipoprotein in patients with coronary heart disease
Article first published online: 23 APR 2008
Volume 6, Issue 3, pages 230–235, September 1974
How to Cite
Berg, K., Dahlén, G. and Frick, M. H. (1974), Lp(a) lipoprotein and pre-β1-lipoprotein in patients with coronary heart disease. Clinical Genetics, 6: 230–235. doi: 10.1111/j.1399-0004.1974.tb00657.x
- Issue published online: 23 APR 2008
- Article first published online: 23 APR 2008
- Received 13 May, accepted for publication 31 May 1974
Certain properties of the atypical serum lipoprotein, referred to as pre-β1-lipoprotein, suggested that it might be identical to the lipoprotein carrying the Lp(a) antigen: Lp(a) lipoprotein. Both lipoprotein phenomena are under genetic control and occur in a certain proportion of healthy people. Pre-β1-lipoprotein occurs more frequently in patients with coronary heart disease (CHD) than in the healthy population.
The present study of Finnish CHD patients was undertaken to investigate whether a close relationship could be revealed between pre-β1-lipoprotein and Lp(a) lipoprotein, as well as between Lp(a) lipoprotein and CHD. Both expectations were realised, and we conclude that pre-β1-lipoprotein is very closely related, if not identical to Lp(a) lipoprotein.
If the present results are confirmed in future studies, serum analysis for Lp(a) lipoprotein/pre-β1-lipoprotein may become a useful tool for the identification in early life of members of a subpopulation which is particularly at risk for developing CHD.