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Sex-linked deafness


Dr Patrick J. Willems, GENDIA, Amerikalei 62, 2000 Antwerp, Belgium.
Tel.: +32 3 3030801;
fax: +32 3 2387770;


Many human syndromes associated with hearing loss are caused by disease genes located on the X chromosome, but few X-linked loci for non-syndromic hearing loss have been reported. Surprisingly, a Y-linked locus has been identified, representing one of the only disease loci on the Y chromosome. This study reviews the different sex-linked genes and loci on the X- and Y chromosome leading to syndromic and especially non-syndromic hearing loss.