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VIP gene variants related to idiopathic pulmonary arterial hypertension in Chinese population

Authors

  • Y Zhang,

    1. Pathology and Physiology Research Center
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  • J-Q Zhang,

    1. Pathology and Physiology Research Center
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  • Z-H Liu,

    1. Center for Diagnosis and Management of Pulmonary Vascular Diseases
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  • C-M Xiong,

    1. Center for Diagnosis and Management of Pulmonary Vascular Diseases
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  • X-H Ni,

    1. Center for Diagnosis and Management of Pulmonary Vascular Diseases
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  • R-T Hui,

    1. Sino-German Laboratory for Molecular Medicine, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People's Republic of China
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  • J-G He,

    Corresponding author
    1. Center for Diagnosis and Management of Pulmonary Vascular Diseases
      Jian-Guo He, Center for Diagnosis and Management of Pulmonary Vascular Diseases, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Nr.167 Bei-Li-Shi Road, Xi-Cheng District, Beijing 100037, People's Republic of China.
      Tel.: 86 10 88398060;
      e-mail: hejianguofw@gmail.com
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  • J-L Pu

    Corresponding author
    1. Pathology and Physiology Research Center
      Jie-Lin Pu, Pathology and Physiology Research Center, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Nr. 167 Bei-Li-Shi Road, Xi-Cheng District, Beijing 100037, People's Republic of China.
      Tel.: 86 10 88398618;
      fax: 86 10 88398455;
      e-mail: jielinpu@yahoo.com
    Search for more papers by this author

Jian-Guo He, Center for Diagnosis and Management of Pulmonary Vascular Diseases, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Nr.167 Bei-Li-Shi Road, Xi-Cheng District, Beijing 100037, People's Republic of China.
Tel.: 86 10 88398060;
e-mail: hejianguofw@gmail.com

Jie-Lin Pu, Pathology and Physiology Research Center, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Nr. 167 Bei-Li-Shi Road, Xi-Cheng District, Beijing 100037, People's Republic of China.
Tel.: 86 10 88398618;
fax: 86 10 88398455;
e-mail: jielinpu@yahoo.com

Abstract

A variety of studies has linked vasoactive intestinal peptide (VIP) to idiopathic pulmonary arterial hypertension (IPAH). In this study, we investigated the correlation between VIP gene variants and IPAH in Chinese population. A total of 81 consecutive unrelated patients diagnosed as IPAH from 2006 to 2008 and 250 controls were included in the study. VIP gene variants were screened by direct sequencing, and VIP serum level was determined by enzyme-linked immunosorbent assay. Clinical and hemodynamic data of all patients were also obtained. The variant g.8129T→C in exon 7 was found to be the only variant in the coding region of VIP gene with a significantly higher frequency in patients (40.7%) than in control samples (15.2%). Moreover, there was marked difference in VIP serum level and hemodynamic data between IPAH patients with and without the variant. The variant g.8129T→C in exon 7 of VIP gene was correlated with the clinical phenotype of lower VIP serum level, higher mean pulmonary artery pressure and pulmonary vascular resistance in patients with IPAH comparing to those in patients without this variant. The VIP gene variant g.8129T→C may be one of the risk factors in the pathogenesis of IPAH.

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